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Volumn 18, Issue 18, 2010, Pages 6934-6952

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

(20) Niculescu Duvaz, Dan a Niculescu Duvaz, Ion a Suijkerbuijk, Bart M J M a Ménard, Delphine a Zambon, Alfonso a Nourry, Arnaud a Davies, Lawrence a Manne, Helen A a Friedlos, Frank a Ogilvie, Lesley a Hedley, Douglas a Takle, Andrew K c Wilson, David M c Pons, Jean Francois d Coulter, Tom d Kirk, Ruth b Cantarino, Neus b Whittaker, Steven b Marais, Richard b Springer, Caroline J a

a INSTITUTE OF CANCER RESEARCH (United Kingdom)

b IMPERIAL CANCER RESEARCH FUND (United Kingdom)

c GLAXOSMITHKLINE (United Kingdom)

d EVOTEC UK LTD (United Kingdom)

Author keywords

Anticancer; BRAF; Dihydroindenopyrazole; Kinase inhibitors; Melanoma; Triarylimidazole

Indexed keywords

6 [2 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL] 5 PYRIDIN 4 YL 3H IMIDAZOL 4 YL] 2,4 DIHYDROINDENO[1,2 C]PYRAZOLE; ANTINEOPLASTIC AGENT; B RAF KINASE INHIBITOR; DIMETHYL [2 [4 [5 [4 (1H PYRAZOL 3 YL)PHENYL] 4 PYRIDIN 4 YL 1H IMIDAZOL 2 YL]PHENOXY]ETHYL]AMINE; FURAN; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; VIRUS ONCOGENE;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; FEMALE; FURANS; HUMANS; IMIDAZOLES; MICE; MUTATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS B-RAF; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 77956341754 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.06.031 Document Type: Article

Times cited : (32)

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