Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Bish, Lawrence T ^a   Morine, Kevin J ^a   Sleeper, Meg M ^b   Sweeney, H Lee ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYOCYTE ENHANCER FACTOR 2; MYOSTATIN; PHENYLEPHRINE; TRANSCRIPTION FACTOR NFAT3; MEF2A PROTEIN, MOUSE; MYOGENIC FACTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL SIZE; CELL STRESS; CONTROLLED STUDY; GENE EXPRESSION; GROWTH REGULATION; HEART FAILURE; HEART MUSCLE CELL; HEART SIZE; MOUSE; NEWBORN; NONHUMAN; PROTEIN DNA BINDING; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; UPREGULATION;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; MUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANIMALS, NEWBORN; CELL PROLIFERATION; CELL SIZE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MICE; MYOCYTES, CARDIAC; MYOGENIC REGULATORY FACTORS; MYOSTATIN; NFATC TRANSCRIPTION FACTORS; PHENYLEPHRINE; PROTO-ONCOGENE PROTEINS C-AKT; STRESS, PHYSIOLOGICAL; UP-REGULATION;

EID: 77956302033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010230     Document Type: Article

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