Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse

Journal of Endocrinology

Volumn 194, Issue 1, 2007, Pages 63-76

  Artaza, Jorge N ^a   Reisz Porszasz, Suzanne ^a   Dow, Joan S ^b   Kloner, Robert A ^b   Tsao, James ^a   Bhasin, Shalender ^a,c   Gonzalez Cadavid, Nestor F ^a  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CYCLIN DEPENDENT KINASE 2; FORMAZAN; MONOCLONAL ANTIBODY; MYOSTATIN; PROTEIN P21;

ANGIOCARDIOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL DIVISION; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; EMBRYO; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE SIZE; HEART MUSCLE CELL; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; GENE EXPRESSION; HEART VENTRICLES; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCYTES, CARDIAC; ORGAN SIZE; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROKE VOLUME; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; VIDEO RECORDING;

EID: 34547435196     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/JOE-07-0072     Document Type: Article

References (54)

1. Artaza J, Bhasin S, Mallidis C, Taylor W, Ma K & Gonzalez-Cadavid NF 2002 Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. Journal of Cellular Physiology 190 170-179.
2. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF & Gonzalez-Cadavid NF 2005 Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 146 3547-3557.
3. Artaza JN, Singh R, Ferrini MG, Braga M, Gonzalez-Cadavid NF 2006 Myostatin promotes collagen deposition in C3H 10T (1/2) mesenchymal multipotent cells through the SMAD signaling pathway. Endocrine Society Meeting, Boston, MA, P1-430. (Abstract).
4. Brostrom MA, Mourad F & Brostrom CO 2001 Regulated expression of GRP78 during vasopressin-induced hypertrophy of heart-derived myocytes. Journal of Cellular Biochemistry 83 204-217.
5. Bunger L, Ott G, Varga L, Schlote W, Rehfeldt C, Renne U, Williams JL & Hill WG 2004 Marker-assisted introgression of the compact mutant myostatin allele MstnCmpt-d11Abc into a mouse line with extreme growth effects on body composition and muscularity. Genetical Research 84 161-173.
6. Caiozzo V, Reisz-Porszasz S, Bhasin S, Gonzalez-Cadavid N 2005 Mechanical properties of plantaris muscle in myostatin knock out mice. FASEB/ Experimental Biology Meeting, San Diego, LB 136. (Abstract).
7. Chen QM, Tu VC, Wa Y & Bahl JJ 2000 Hydrogen peroxide dose dependent induction of cell death or hypertrophy in cardiomyocytes. Archives of Biochemistry and Biophysics 373 242-248.
8. Cohn KD, Liang HY, Sherry R, Abraham T & Wagner KR 2007 Myostatin does not regulate cardiac hypertrophy or fibrosis. Neuromuscular Disorders 17 290-296.
9. Cook SA, Matsui T, Li L & Rosenzweig A 2002 Transcriptional effects of chronic Akt activation in the heart. Journal of Biological Chemistry 277 22528-22533.
10. Dai W, Hale SL, Martin BJ, Kuang JQ, Dow JS, Wold LE & Kloner RA 2005 Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 112 214-223.
11. Dominique JE & Gerard C 2006 Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects. Experimental Cell Research 312 2401-2414.
12. Ferrini MG, Magee TR, Vernet D, Qian A, Valente EG, Bhasin S, Rajfer J & Gonzalez-Cadavid NF 2004 Myostatin is expressed in the normal tunica albuginea and Peyronie's fibrotic plaque in parallel to myofibroblast differentiation. Journal of Urology 171 329 (A1248).
13. Gaussin V & Depre C 2005 Myostatin, the cardiac chalone of insulin-like growth factor-1. Cardiovascular Research 68 347-349.
14. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M et al. 1998 Organization of the human mycistatin gene and expression in healthy men and HIV-infected men with muscle wasting. PNAS 95 14938-14943.
15. Gregory DJ, Waldbieser GC & Bosworth BG 2004 Cloning and characterization of myogenic regulatory genes in three Ictalurid species. Animal Genetics 35 425-430.
16. Hacker TA, McKiernan SH, Douglas PS, Warragat J & Aiken JM 2006 Age-related changes in cardiac structure and function in Fischer 344 X Brown Norway hybrid rats. American Journal of Physiology, Heart and Circulatory Physiology 290 H304-H311.
17. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM & Qiu Y 2002 The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. Journal of Biological Chemistry 277 40735-40741.
18. Hill JJ, Qiu Y, Hewick RM & Wolfman NM 2003 Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Molecular Endocrinology 17 1144-1154.
19. Huang CY, Kuo WW, Chueh PJ, Tseng CT, Chou MY & Yang JJ 2004 Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. Biochemical and Biophysical Research Communications 324 424-431.
20. Khan R & Sheppard R 2006 Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118 10-24.
21. Lee S-J 2004 Regulation of muscle mass by myostatin. Annual Review of Cell and Developmental Biology 20 61-86.
22. Magee TR, Artaza JN, Ferrini MG, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J & Gonzalez-Cadavid NF 2006 Myostatin shRNA gene therapy increases muscle mass. Journal of Gene Medicine 8 1171-1181.
23. McCroskery S, Thomas M, Maxwell L, Sharma M & Kambadur R 2003 Myostatin negatively regulates satellite cell activation and self-renewal. Journal of Cell Biology 162 1135-1147.
24. McCroskery S, Thomas M, Platt L, Hennebry A, Nishimura T, McLeay L, Sharma M & Kambadur R 2005 Improved muscle healing through enhanced regeneration and reduced fibrosis in myostatin-null mice. Journal of Cell Science 118 3531-3541.
25. McFarland DC, Velleman SG, Pesall JE & Liu C 2006 Effect of myostatin on turkey myogenic satellite cells and embryonic myoblasts. Comparative Biochemistry and Physiology Part A, Molecular and Integrative Physiology 144 501-508.
26. McKoy G, Bicknell KA, Patel K & Brooks G 2007 Developmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardomyocyte proliferation. Cardiovascular Research 74 304-312.
27. McPherron AC & Lee SJ 1997 Double muscling in cattle due to mutations in the myostatin gene. PNAS 94 12457-12461.
28. McPherron AC, Lawler AM & Lee SJ 1997 Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387 83-90.
29. Merten KE, Jiang Y, Feng W & Kang YJ 2006 Calcineurm activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway. Journal of Pharmacology and Experimental Therapeutics 319 934-940.
30. Morissette MR, Cook SA, Foo S, McKoy G, Ashida N, Novikov M, Scherrer-Crosbie M, Li L, Matsui T, Brooks G et al. 2006 Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circulation Research 99 15-24.
31. Muller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW & Kloner RA 2002 Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation 105 1720-1726.
32. Ostbye TK, Galloway TF, Nielsen C, Gabestad I, Bardal T & Andersen O 2001 The two myostatin genes of Atlantic salmon (Salmo salar) are expressed in a variety of tissues. European Journal of Biochemistry 268 5249-5257.
33. Parsons SA, Millay DP, Sargent MA, McNally EM & Molkentin JD 2006 Age dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophv. American Journal of Pathology 168 1975-1985.
34. Reisz-Porszasz S. Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ & Gonzalez-Cadavid NF 2003 Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. American Journal of Physiology. Endocrinology and Metabolism 285 E876-E888.
35. Rios R, Fernandez-Nocelos S, Carneiro I, Arce VM & Devesa J 2004 Differential reponse to exogenous and endogenous myostatin in myoblasts suggests that myostatin acts as an autocrine factor in vivo. Endocrinology 145 2795-2801
36. Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J Jr & Chien KR 1994 Molecular and physiological alterations in murine ventricular dysfunction. PNAS 91 2694-2698.
37. Rozenberg S, Tavernier B, Riou B, Swynghedauw B, Page CL, Boucher F, Leiris J & Besse S 2006 Severe impairment of ventricular compliance accounts for advanced age-associated hemodynamic dysfunction in rats. Experimental Gerontology 41 289-295.
38. Sakuma K, Nakao R, Inashima S, Hirata M, Kubo T & Yasuhara M 2004 Marked reduction of focal adhesion kinase, serum response factor and inyocyte enhancer factor 2C, but increase in RhoA and myostatin in the hindlimb dy mouse muscles. Acta Neuropathologica 108 241-249.
39. Schreier T, Kedes L & Gahlmann R 1990 Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. Journal of Biological Chemistry 265 21247-21253.
40. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W, Braun T, Tobin JF & Lee SJ 2004 Myostatin mutation associated with gross muscle hypertrophy in a child. New England Journal of Medicine 350 2682-2688.
41. Sharma M, Kambadur R, Matthews KG, Somers WG, Devlin GF, Conaglen JV, Fowke PJ & Bass JJ 1999 Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct. Journal of Cellular Physiology 180 1-9.
42. Shield MA, Haugen HS, Vlegg CH & Hauschka SD 1996 E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscle and cardiac muscle of transgenic mice. Molecular and Cellular Biology 16 5058-5068.
43. Shyu KG, Ko WH, Yang WS, Wang BW & Kuan P 2005 Insulin-like growth Facror-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes. Cardiovascular Research 68 405-414.
44. Shyu KG, Lu MJ, Wang BW, Sun HY & Chang H 2006 Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. European Journal of Clinical Investigation 36 713-719.
45. Szabo G, Dallmann G, Muller G, Patthy L, Soller M & Varga L 1998 A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice. Mammalian Genome 9 671-672.
46. Tantini B, Fiumana E, Cetrullo S, Pignatti C, Bonavita F, Shantz LM, Giordano E, Muscari C, Flamigni F, Guarnieri C et al. 2006 Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia. Journal of Molecular and Cellular Cardiology 40 775-782.
47. Taylor W, Bhasin S, Artaza J, Byhower F, Azam MA, Willard DH, Kull F & Gonzalez-Cadavid NF 2001 Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. American Journal of Physiology 280 E221-E228.
48. Tsao J, Verner D, Nolazco G, Artaza JN & Gonzalez-Cadavid NF 2006 Androgen modulation of cell lineage commitment by muscle-derived stem cells. Journal of Investigative Medicine 54 S97 (Abstract).
49. Tsuchida K 2006 The role of myostatin and bone morphogenetic proteins in muscular disorders. Expert Opinion on Biological Therapy 6 147-154.
50. Wagner KR, McPherron AC, Winik N & Lee SJ 2002 Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Annals of Neurology 52 832-836.
51. Yao M, Dieterle T, Hale SL, Dow JS, Kedes LH, Peterson KL & Kloner RA 2003 Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. Journal of Molecular and Cellular Cardiology 35 661-670.
52. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J & Gonzalez-Cadavid NF 2002 Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. Journal of Nutrition, Health and Aging 6 343-348.
53. Zhu X, Hadhazy M, Wehling M, Tidball JG & McNally EM 2000 Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Letters 474 71-75.
54. Zimmers TA, Davies MV, Koniaris LG, Haynes F, Esquela AF, Tomkinson KN, McPherron AC, Wolfman NM & Lee SJ 2002 Induction of cachexia in mice by systemically administered myostatin. Science 296 1486-1488.