A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle

Biochemical and Biophysical Research Communications

Volumn 293, Issue 1, 2002, Pages 247-251

  Nishi, Masumi ^a   Yasue, Akihiro ^a   Nishimatu, Shinichirou ^b   Nohno, Tsutomu ^b   Yamaoka, Takashi ^a   Itakura, Mitsuo ^a   Moriyama, Keiji ^a   Ohuchi, Hideyo ^a   Noji, Sumihare ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Dominant negative; GDF 8; Hyperplasia; Hypertrophy; Mouse; Myostatin; Skeletal muscle; Transgenic

Indexed keywords

MYOSTATIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HYPERPLASIA; MALE; MISSENSE MUTATION; MOUSE; MUSCLE DEVELOPMENT; MUSCLE FIBRIL; MUSCLE HYPERTROPHY; MUSCLE MASS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKELETAL MUSCLE; TRANSGENIC MOUSE;

BOS TAURUS; MUS MUSCULUS;

EID: 0036296159     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00209-7     Document Type: Article

References (10)

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4. The ontogeny of myostatin, follistatin, and activin-B mRNA expression during chicken embryonic development
5. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting
6. Double muscling in cattle due to mutations in the myostatin gene
7. Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle
8. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
9. Efficient selection for high-expression transfectants with a novel eukaryotic vector
10. Regulation of myostatin activity and muscle growth