O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk

Journal of Oral Pathology and Medicine

Volumn 39, Issue 8, 2010, Pages 645-650

  Huang, Sung Hsien ^a   Chang, Pei Yang ^b   Liu, Chung Ji ^a,c,d   Lin, Ming Wei ^a   Hsia, Kan Tai ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI CITY HOSPITAL   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

^d Mackay Medicine   (Taiwan)

Author keywords

O6 methylguanine DNA methyltransferase; polymorphisms

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; CYTOSINE; LEUCINE; PHENYLALANINE; THYMINE;

ADULT; ARTICLE; CANCER RISK; CANCER SURVIVAL; CASE CONTROL STUDY; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SQUAMOUS CELL CARCINOMA; AGE; CODON; COMPARATIVE STUDY; DISEASE FREE SURVIVAL; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; MOUTH TUMOR; PRECANCER; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL RATE; TAIWAN;

AGE FACTORS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CODON; CYTOSINE; DISEASE-FREE SURVIVAL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HUMANS; LEUCINE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MOUTH NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PHENYLALANINE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECANCEROUS CONDITIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SEQUENCE ANALYSIS, DNA; SURVIVAL RATE; TAIWAN; THYMINE;

EID: 77956285363     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2009.00880.x     Document Type: Article

References (38)

1. Scully C, Bagan J. Oral squamous cell carcinoma overview. Oral Oncol 2009 45 : 301 308.
2. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009 45 : 309 316.
3. Bsoul SA, Huber MA, Terezhalmy GT. Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J Contemp Dent Pract 2005 6 : 1 16.
4. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin 2002 52 : 195 215.
5. Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 2008 87 : 14 32.
6. Akopyan G, Bonavida B. Understanding tobacco smoke carcinogen NNK and lung tumorigenesis. Int J Oncol 2006 29 : 745 752.
7. Mitra S. MGMT: a personal perspective. DNA Repair (Amst) 2007 6 : 1064 1070.
8. Kaina B, Christmann M, Naumann S, et al. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst) 2007 6 : 1079 1099.
9. Li C, Liu J, Li A, et al. Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. Cancer Lett 2005 227 : 49 57.
10. Cohet C, Borel S, Nyberg F, et al. Exon 5 polymorphisms in the O6-alkylguanine DNA alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. Cancer Epidemiol Biomarkers Prev 2004 13 : 320 323.
11. Pegg AE, Fang Q, Loktionova NA. Human variants of O6-alkylguanine-DNA alkyltransferase. DNA Repair (Amst) 2007 6 : 1071 1078.
12. Bugni JM, Han J, Tsai MS, et al. Genetic association and functional studies of major polymorphic variants of MGMT. DNA Repair (Amst) 2007 6 : 1116 1126.
13. Egyhazi S, Ma S, Smoczynski K, et al. Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden. Hum Mutat 2002 20 : 408 409.
14. Ma S, Egyhazi S, Ueno T, et al. O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma. Br J Cancer 2003 89 : 1517 1523.
15. Hazra TK, Roy R, Biswas T, et al. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase. Biochemistry 1997 36 : 5769 5776.
16. Daniels DS, Mol CD, Arvai AS, et al. Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO J 2000 19 : 1719 1730.
17. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res 1987 95 : 229 249.
18. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 21 : 263 265.
19. Zhao JH. 2LD, GENECOUNTING and HAP: computer programs for linkage disequilibrium analysis. Bioinformatics 2004 20 : 1325 1326.
20. Hu Z, Wang H, Shao M, et al. Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. Hum Mutat 2007 28 : 431 440.
21. Povey AC, Margison GP, Santibanez-Koref MF. Lung cancer risk and variation in MGMT activity and sequence. DNA Repair (Amst) 2007 6 : 1134 1144.
22. Shen J, Terry MB, Gammon MD, et al. MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. Carcinogenesis 2005 26 : 2131 2137.
23. Han J, Tranah GJ, Hankinson SE, et al. Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk. Pharmacogenet Genomics 2006 16 : 469 474.
24. Huang WY, Olshan AF, Schwartz SM, et al. Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis. Cancer Epidemiol Biomarkers Prev 2005 14 : 1747 1753.
25. Kietthubthew S, Sriplung H, Au WW, et al. Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. Int J Hyg Environ Health 2006 209 : 21 9.
26. Otsuka M, Abe M, Nakabeppu Y, et al. Polymorphism in the human O6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP analysis. Pharmacogenetics 1996 6 : 361 363.
27. Zhang M, Huang WY, Andreotti G, et al. Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. Cancer Epidemiol Biomarkers Prev 2008 17 : 2123 2127.
28. Ritchey JD, Huang WY, Chokkalingam AP, et al. Genetic variants of DNA repair genes and prostate cancer: a population-based study. Cancer Epidemiol Biomarkers Prev 2005 14 : 1703 1709.
29. Huang J, Ye F, Chen H, et al. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis 2007 28 : 1314 1322.
30. Anonymous. Cancer registry annual report in Taiwan area, 2008. Taipei : Department of Health The Executive Yuan, ROC, 2009.
31. Liu Y, Scheurer ME, El-Zein R, et al. Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev 2009 18 : 204 214.
32. Bigler J, Ulrich CM, Kawashima T, et al. DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. Cancer Epidemiol Biomarkers Prev 2005 14 : 2501 2508.
33. Jiao L, Bondy ML, Hassan MM, et al. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Cancer Detect Prev 2006 30 : 284 291.
34. Chae MH, Jang JS, Kang HG, et al. O6-alkylguanine-DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer. Mol Carcinog 2006 45 : 239 249.
35. Huang CC, Chien WP, Wong RH, et al. NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer. Environ Mol Mutagen 2009 50 : 127 133.
36. Margison GP, Heighway J, Pearson S, et al. Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells. Carcinogenesis 2005 26 : 1473 1480.
37. Krzesniak M, Butkiewicz D, Samojedny A, et al. Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet 2004 68 : 300 312.
38. Ogino S, Hazra A, Tranah GJ, et al. MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 2007 28 : 1985 1990. None of the authors have any financial or personal relationships with other people or organizations that could inappropriately influence or bias their contribution to this paper.