Viral protein VP4 is a target of human antibodies enhancing coxsackievirus B4- and B3-induced synthesis of alpha interferon

Journal of Virology

Volumn 79, Issue 22, 2005, Pages 13882-13891

  Chehadeh, Wassim ^a,e   Lobert, Pierre Emmanuel ^a   Sauter, Pierre ^a   Goffard, Anne ^a   Lucas, Bernadette ^a   Weill, Jacques ^b   Vantyghem, Marie Christine ^b   Alm, Gunnar ^d   Pigny, Pascal ^c   Hober, Didier ^a  

^a University Lille   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c INSERM   (France)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^e KUWAIT UNIVERSITY   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; COXSACKIE VIRUS B4 ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS PROTEIN; VIRUS PROTEIN VP4;

ADULT; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B3; COXSACKIE VIRUS B4; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IN VITRO STUDY; INCUBATION TIME; INHIBITION KINETICS; INTERFERON PRODUCTION; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; VIRUS CAPSID;

ADULT; ANTIBODIES, VIRAL; CAPSID PROTEINS; CHILD; CROSS REACTIONS; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS B, HUMAN; HUMANS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; REFERENCE VALUES;

COXSACKIEVIRUS; MIRIDAE;

EID: 27644570048     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.22.13882-13891.2005     Document Type: Article

References (47)

1. Andreoletti, L., D. Hober, C. Hober-Vandenberghe, S. Belaich, M. C. Vantyghem, J. Lefebvre, and P. Wattre. 1997. Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus. J. Med. Virol. 52:121-127.
2. Bosi, E., R. Minelli, E. Bazzigaluppi, and M. Salvi. 2001. Fulminant autoimmune type 1 diabetes during interferon-alpha therapy: a case of Th1-mediated disease? Diabet. Med. 18:329-332.
3. Boyum, A. 1976. Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. Suppl. 5:9-15.
4. Brahimi, K., J. L. Perignon, M. Bossus, H. Gras, A. Tartar, and P. Druilhe. 1993. Fast immunopurification of small amounts of specific antibodies on peptides bound to ELISA plates. J. Immunol. Methods 162:69-75.
5. Caggana, M., P. Chan, and A. Ramsingh. 1993. Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype. J. Virol. 67:4797-4803.
6. Cederblad, B., S. Blomberg, H. Vallin, A. Perers, G. V. Aim, and L. Ronnblom. 1998. Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha-producing cells. J. Autoimmun. 11:465-470.
7. Chakrabarti, D., B. Hultgren, and T. A. Stewart. 1996. IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2. J. Immunol. 157:522-528.
8. Chehadeh, W., J. Kerr-Conte, F. Pattou, G. Aim, J. Lefebvre, P. Wattre, and D. Hober. 2000. Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells. J. Virol. 74:10153-10164.
9. Chehadeh, W., J. Weill, M. C. Vantyghem, G. Aim, J. Lefebvre, P. Wattre, and D. Hober. 2000. Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection. J. Infect. Dis. 181:1929-1939.
10. Chehadeh, W., A. Bouzidi, G. Aim, P. Wattre, and D. Hober. 2001. Human antibodies isolated from plasma by affinity chromatography increase the coxsackievirus B4-induced synthesis of interferon-alpha by human peripheral blood mononuclear cells in vitro. J. Gen. Virol. 82:1899-1907.
11. Chu, P. Y., K. H. Lin, K. P. Hwang, L. C. Chou, C. F. Wang, S. R. Shih, J. R. Wang, Y. Shimada, and H. Ishiko. 2001. Molecular epidemiology of enterovirus 71 in Taiwan. Arch. Virol. 146:589-600.
12. Clements, G. B., D. N. Galbraith, and K. W. Taylor. 1995. Coxsackie B virus infection and onset of childhood diabetes. Lancet 346:221-223.
13. Fabris, P., C. Betterle, N. A. Greggio, R. Zanchetta, E. Bosi, M. R. Biasin, and F. de Lalla. 1998. Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis. J. Hepatol. 28:514-517.
14. Feldman, S. B., M. Ferraro, H. M. Zheng, N. Patel, S. Gould-Fogerite, and P. Fitzgerald-Bocarsly. 1994. Viral induction of low frequency interferon-a producing cells. Virology 204:1-7.
15. Foulis, A. K., M. A. Farquharson, and A. Meager. 1987. Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet ii: 1423-1427.
16. Hober, D., W. Chehadeh, A. Bouzidi, and P. Wattre. 2001. Antibody-dependent enhancement of coxsackievirus B4 infectivity of human peripheral blood mononuclear cells results in increased interferon-alpha synthesis. J. Infect. Dis. 184:1098-1108.
17. Hober, D., W. Chehadeh, J. Weill, C. Hober, M. C. Vantyghem, P. Gronnier, and P. Wattré. 2002. Circulating and cell-bound antibodies increase the coxsackievirus B4-induced production of IFN-α by peripheral blood mononuclear cells of patients with type 1 diabetes. J. Gen. Virol. 83:2169-2176.
18. Hyoty, H., M. Hiltunen, M. Knip, M. Laakkonen, P. Vahasalo, J. Karjalainen, P. Koskela, M. Roivainen, P. Leinikki, T. Hovi, et al. 1995. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 44:652-657.
19. Hyoty, H. 2002. Enterovirus infections and type 1 diabetes. Ann. Med. 34:138-147.
20. Hyoty, H., and K. W. Taylor. 2002. The role of viruses in human diabetes. Diabetologia 45:1353-1361.
21. Ishiko, H., Y. Shimada, M. Yonaha, O. Hashimoto, A. Hayashi, K. Sakae, and N. Takeda. 2002. Molecular diagnosis of human enteroviruses by phylogeny-based classification by use of the VP4 sequence. J. Infect. Dis. 185: 744-754.
22. Kubo, H., N. Iritani, and Y. Seto. 2002. Molecular classification of enteroviruses not identified by neutralization tests. Emerg. Infect. Dis. 8:298-304.
23. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
24. Li, Q., A. G. Yafal, Y. M. Lee, J. Hogle, and M. Chow. 1994. Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature. J. Virol. 68:3965-3970.
25. Lonnrot, M., K. Salminen, M. Knip, K. Savola, P. Kulmala, P. Leinikki, T. Hyypia, H. K. Akerblom, and H. Hyoty. 2000. Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: a prospective study. Childhood Diabetes in Finland (DiMe) Study Group. J. Med. Virol. 61:214-220.
26. Mateu, M. G. 1995. Antibody recognition of picornaviruses and escape from neutralization: a structural view. Virus Res. 38:1-24.
27. Melnick, J. L. 1996. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p. 655-712. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Channock, J. L. Melnick, T. P. Monath, et al. (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
28. Minor, P. D. 1990. Antigenic structure of picornaviruses. Curr. Top. Microbiol. Immunol. 161:121-154.
29. Muckelbauer, J. K., M. Kremer, I. Minor, G. Diana, F. J. Dutko, J. Groarke, D. C. Pevear, and M. G. Rossmann. 1995. The structure of coxsackievirus B3 at 3.5 A resolution. Structure 3:653-667.
30. Nairn, C., D. N. Galbraith, K. W. Taylor, and G. B. Clements. 1999. Enterovirus variants in the serum of children at the onset of type 1 diabetes mellitus. Diabet. Med. 16:509-513.
31. Oberste, M. S., K. Maher, D. R. Kilpatrick, M. R. Flemister, B. A. Brown, and M. A. Pallansch. 1999. Typing of human enteroviruses by partial sequencing of VP1. J. Clin. Microbiol. 37:1288-1293.
32. Reimann, B. Y., R. Zell, and R. Kandolf. 1991. Mapping of a neutralizing antigenic site of coxsackievirus B4 by construction of an antigen chimera. J. Virol. 65:3475-3480.
33. Rewers, M., and M. Atkinson. 1995. The possible role of enteroviruses in diabetes mellitus, p. 353-384. In H. A. Rotbart (ed.), Human enterovirus infections. Library of Congress, Washington, D.C.
34. Rombaut, B., R. Vrijsen, and A. Boeye. 1985. Stabilization by host cell components and Mg2+ of the neutralization epitopes of poliovirus. J. Gen. Virol. 66(Pt 2):303-307.
35. See, D. M., and J. G. Tilles. 1995. Pathogenesis of virus-induced diabetes in mice. J. Infect. Dis. 171:1131-1138.
36. Singh, S., V. T. Chow, K. P. Chan, A. E. Ling, and C. L. Poh. 2000. RT-PCR, nucleotide, amino acid and phylogenetic analyses of enterovirus type 71 strains from Asia. J. Virol. Methods 88:193-204.
37. Stanway, G., T. Hovi, N. J. Knowles, and T. Hyypiä. 2002. Molecular and biological basis of picornavirus taxonomy, p. 17-21. In B. L. Semley and E. Wimmer (ed.), Molecular basis of picornavirus. ASM Press, Washington, D.C.
38. Stewart, T. A., B. Hultgren, X. Huang, S. Pitts-Meek, J. Hully, and N. J. MacLachlan. 1993. Induction of type I diabetes by interferon-alpha in transgenic mice. Science 260:1942-1946.
39. Varela-Calvino, R., and M. Peakman. 2003. Enteroviruses and type 1 diabetes. Diabetes Metab. Res. Rev. 19:431-441.
40. Wesche, B., E. Jaeckel, C. Trautwein, H. Wedemeyer, A. Falorni, H. Frank, M. A. von Zur, M. P. Manns, and G. Brabant. 2001. Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C. Gut 48:378-383.
41. Wetz, K., and K. O. Habermehl. 1979. Topographical studies on poliovirus capsid proteins by chemical modification and cross-linking with bifunctional reagents. J. Gen. Virol. 44:525-534.
42. Wetz, K., and K. O. Habermehl. 1982. Specific cross-linking of capsid proteins to virus RNA by ultraviolet irradiation of poliovirus. J. Gen. Virol. 59:397-401.
43. Yin, H., A. K. Berg, T. Tuvemo, and G. Frisk. 2002. Enterovirus RNA is found in peripheral blood mononuclear cells in a majority of type 1 diabetic children at onset. Diabetes 51:1964-1971.
44. Ylipaasto, P., K. Klingel, A. M. Lindberg, T. Otonkoski, R. Kandolf, T. Hovi, and M. Roivainen. 2004. Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells. Diabetologia 47:225-239.
45. Yoon, J. W., M. Austin, T. Onodera, and A. L. Notkins. 1979. Isolation of a virus from the pancreas of child with diabetic ketoacidosis. N. Engl. J. Med. 300:1173-1179.
46. Yoon, J. W., T. Onodera, and A. L. Notkins. 1978. Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie virus B4. J. Exp. Med. 148:1068-1080.
47. Yoon, J. W. 1990. The role of viruses and environmental factors in the induction of diabetes. Curr. Top. Microbiol. Immunol. 164:95-123.