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0041820123
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Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes
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Westerholm-Ormio M, Vaarala O, Pihkala P, et al. Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 2003; 52:2287-2295.
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In-vitro-deranged intestinal immune response to gliadin in type 1 diabetes
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Tiittanen M, Westerholm-Ormio M, Verkasalo M, et al. Infiltration of Foxp3 expressing cells in jejunal mucosa in celiac disease but not in type 1 diabetes. Clin Exp Immunol 2008; 152:498-507. This study demonstrates that Foxp3 activity is not increased in the small intestine of patients with type 1 diabetes despite the subclinical inflammation, which raises the question of defective regulatory mechanisms.
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Tiittanen M, Westerholm-Ormio M, Verkasalo M, et al. Infiltration of Foxp3 expressing cells in jejunal mucosa in celiac disease but not in type 1 diabetes. Clin Exp Immunol 2008; 152:498-507. This study demonstrates that Foxp3 activity is not increased in the small intestine of patients with type 1 diabetes despite the subclinical inflammation, which raises the question of defective regulatory mechanisms.
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4
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IL-4 directly modulates function of a model human intestinal epithelium
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Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis- like process
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Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction
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The investigation provides evidence that proinflammatory cytokines cause tight-junction barrier disruption by altering the lipid composition of tight-junctions
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Li Q, Zhang Q, Wang M, et al. Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction. Clin Immunol 2008; 126: 67-80. The investigation provides evidence that proinflammatory cytokines cause tight-junction barrier disruption by altering the lipid composition of tight-junctions.
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Watts, T.1
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Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes
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Neu J, Reverte CM, Mackey AD, et al. Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes. J Pediatr Gastroenterol Nutr 2005; 40:589-595.
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Luopajärvi K, Savilahti E, Virtanen SM, et al. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 2008 [Epub ahead of print]. A unique design of the study reveals that the antibody response to dietary cow's milk proteins is altered already during the early infancy in the children who later in life develop type 1 diabetes.
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Luopajärvi K, Savilahti E, Virtanen SM, et al. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 2008 [Epub ahead of print]. A unique design of the study reveals that the antibody response to dietary cow's milk proteins is altered already during the early infancy in the children who later in life develop type 1 diabetes.
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12
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34249880438
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Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
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TRIGR Study Group
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TRIGR Study Group. Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR). Pediatr Diabetes 2007; 8:117-137.
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Abnormal intestinal permeability to sugars in diabetes mellitus
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14
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Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DOB1 *02 allele
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Kuitunen M, Saukkonen T, Honen J, et al. Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DOB1 *02 allele. Autoimmunity 2002; 35:365-368.
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Ultrastructural mucosal alterations and increased intestinal permeability in nonceliac, type I diabetic patients
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Secondulfo M, Iafusco D, Carratu R, et al. Ultrastructural mucosal alterations and increased intestinal permeability in nonceliac, type I diabetic patients. Dig Liver Dis 2004; 36:35-45.
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Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
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Sapone A, de Magistris L, Pietzak M, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 2006; 55:1443-1449.
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Increased intestinal permeability precedes clinical onset of type 1 diabetes
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Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006; 49:2824-2827.
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Bosi, E.1
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Endocrine self and gut nonself intersect in the pancreatic lymph nodes
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Turley SJ, Lee JW, Dutton-Swain N, et al. Endocrine self and gut nonself intersect in the pancreatic lymph nodes. Proc Natl Acad Sci USA 2005; 102:17729-17733.
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Hänninen A, Nurmela R, Maksimow M, et al. Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol 2007; 170:240-250. A very intriguing study indicating that oral antigen activated T-cells use gut homing receptors to infiltrate the islets in T-cell receptor (TCR) trangenic mouse model of autoimmune diabetes.
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Hänninen A, Nurmela R, Maksimow M, et al. Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol 2007; 170:240-250. A very intriguing study indicating that oral antigen activated T-cells use gut homing receptors to infiltrate the islets in T-cell receptor (TCR) trangenic mouse model of autoimmune diabetes.
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20
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38749083844
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The 'polarizing-tolerizing' mechanism of intestinal epithelium: Its relevance to colonic homeostasis
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An excellent review of the importance of the apical TLR-9 stimulation by commensal bacteria in the control of intestinal inflammation
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Lee J, Gonzales-Navajas JM, Raz E. The 'polarizing-tolerizing' mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol 2008; 30:3-9. An excellent review of the importance of the apical TLR-9 stimulation by commensal bacteria in the control of intestinal inflammation.
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Semin Immunopathol
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, pp. 3-9
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Lee, J.1
Gonzales-Navajas, J.M.2
Raz, E.3
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21
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34247235029
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Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
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This study provides a mechanistic explanation for TLR-2-mediated control of intestinal inflammation: tight-junction regulation
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Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007; 132:1359-1374. This study provides a mechanistic explanation for TLR-2-mediated control of intestinal inflammation: tight-junction regulation.
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, pp. 1359-1374
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Cario, E.1
Gerken, G.2
Podolsky, D.K.3
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22
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33746750046
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Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
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Brugman S, Klatter FA, Visser JT, et al. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 2006; 49: 2105-2108.
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Diabetologia
, vol.49
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Brugman, S.1
Klatter, F.A.2
Visser, J.T.3
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23
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33744498935
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Diabetes preventive gluten-free diet decreases the number of caecal bacteria in nonobese diabetic mice
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Hansen AK, Ling F, Kaas A, et al. Diabetes preventive gluten-free diet decreases the number of caecal bacteria in nonobese diabetic mice. Diabetes Metab Res Rev 2006; 22:220-225.
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Diabetes Metab Res Rev
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Hansen, A.K.1
Ling, F.2
Kaas, A.3
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24
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44349167059
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Dendritic cells in intestinal immune regulation
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A very useful review of intestinal dendritic cells as tolerogenic cells
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Coombes JL, Powrie F. Dendritic cells in intestinal immune regulation. Nat Rev Immunol 2008; 8:435-446. A very useful review of intestinal dendritic cells as tolerogenic cells.
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Nat Rev Immunol
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Coombes, J.L.1
Powrie, F.2
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25
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43649102881
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Drescher KM, Tracy SM. The CVB and etiology of type 1 diabetes. Curr Top Microbiol Immunol 2008; 323:259-274. A comprehensive review of the possible role of enteroviruses in the development of type 1 diabetes.
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Drescher KM, Tracy SM. The CVB and etiology of type 1 diabetes. Curr Top Microbiol Immunol 2008; 323:259-274. A comprehensive review of the possible role of enteroviruses in the development of type 1 diabetes.
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26
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45749153017
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Rotavirus infection accelerates type 1 diabetes in mice with established insulitis
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This experimental study indicates that rotavirus infections may not cause auto-immune response, but rather activate diabetogenic T-cells when the autoimmunity has already been initiated
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Graham KL, Sanders N, Tan Y, et al. Rotavirus infection accelerates type 1 diabetes in mice with established insulitis. J Virol 2008; 82:6139-6149. This experimental study indicates that rotavirus infections may not cause auto-immune response, but rather activate diabetogenic T-cells when the autoimmunity has already been initiated.
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J Virol
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Graham, K.L.1
Sanders, N.2
Tan, Y.3
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27
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23844550325
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Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets
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Ylipaasto P, Kutlu B, Rasilainen S, et al. Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia 2005; 48:1510-1522.
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Ylipaasto, P.1
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28
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34247627376
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Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
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This study provides evidence that human β-cells are infected by Coxsackie virus in vivo and suggests that this may not always be associated with insulitis
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Dotta F, Censini S, van Halteren AG, et al. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A 2007; 104:5115-5120. This study provides evidence that human β-cells are infected by Coxsackie virus in vivo and suggests that this may not always be associated with insulitis.
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Proc Natl Acad Sci U S A
, vol.104
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Dotta, F.1
Censini, S.2
van Halteren, A.G.3
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29
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38449111819
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Activation of innate immune defense mechanisms by signaling through RIG-l/IPS-1 in intestinal epithelial cells
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Hirata Y, Broquet AH, Menchén L, Kagnoff MF. Activation of innate immune defense mechanisms by signaling through RIG-l/IPS-1 in intestinal epithelial cells. J Immunol 2007; 179:5425-5432.
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J Immunol
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Hirata, Y.1
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Menchén, L.3
Kagnoff, M.F.4
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30
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34548433948
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Coxsackievirus entry across epithelial tight junctions requires occludin and the small GT Pases Rab34 and Rab5
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The study provides mechanism for the enterovirus entry from intestine: interference with tight-junction assembly
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Coyne CB, Shen L, Turner JR, Bergelson JM. Coxsackievirus entry across epithelial tight junctions requires occludin and the small GT Pases Rab34 and Rab5. Cell Host Microbe 2007; 2:181-192. The study provides mechanism for the enterovirus entry from intestine: interference with tight-junction assembly.
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Cell Host Microbe
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, pp. 181-192
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Coyne, C.B.1
Shen, L.2
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Bergelson, J.M.4
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31
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10944228240
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The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells
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Nava P, López S, Arias CF, et al. The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci 2004; 117:5509-5519.
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Nava, P.1
López, S.2
Arias, C.F.3
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32
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36849082573
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Detection of enteroviruses in the intestine of type 1 diabetic patients
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This interesting preliminary finding of the presence of enterovirus in the small intestine of patients with long-term diabetes suggests chronic or recurrent infections in the patients
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Oikarinen M, Tauriainen S, Honkanen T, et al. Detection of enteroviruses in the intestine of type 1 diabetic patients. Clin Exp Immunol 2008; 151: 71-75. This interesting preliminary finding of the presence of enterovirus in the small intestine of patients with long-term diabetes suggests chronic or recurrent infections in the patients.
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Clin Exp Immunol
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Oikarinen, M.1
Tauriainen, S.2
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Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes
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Skarsvik S, Puranen J, Honkanen J, et al. Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes. Diabetes 2006; 55:996-1003.
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Skarsvik, S.1
Puranen, J.2
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Gliadin Induces an Increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
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Lammers KM, Lu R, Brownley J, et al. Gliadin Induces an Increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008; 135:194-204.
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Lammers, K.M.1
Lu, R.2
Brownley, J.3
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35
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Wheat protein-induced proinflammatory T helper 1 bias in mesenteric lymph nodes of young diabetes-prone rats
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Chakir H, Lefebvre DE, Wang H, et al. Wheat protein-induced proinflammatory T helper 1 bias in mesenteric lymph nodes of young diabetes-prone rats. Diabetologia 2005; 48:1576-1584.
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Diabetologia
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Chakir, H.1
Lefebvre, D.E.2
Wang, H.3
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36
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Small intestinal enteropathy in nonobese diabetic mice fed a diet containing wheat
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Maurano F, Mazzarella G, Luongo D, et al. Small intestinal enteropathy in nonobese diabetic mice fed a diet containing wheat. Diabetologia 2005; 48:931-937.
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Maurano, F.1
Mazzarella, G.2
Luongo, D.3
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37
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38749102702
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Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes
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Funda DP, Kaas A, Tlaskalová-Hogenová H, Buschard K. Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes. Diabetes Metab Res Rev 2008; 24:59-63.
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Funda, D.P.1
Kaas, A.2
Tlaskalová-Hogenová, H.3
Buschard, K.4
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38
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39749167834
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Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes
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This study indicates that early feeding patterns may cause long-lasting immunological changes
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Caicedo RA, Li N, Des Robert C, et al. Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes. Pediatr Res 2008; 63:303-307. This study indicates that early feeding patterns may cause long-lasting immunological changes.
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Pediatr Res
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Caicedo, R.A.1
Li, N.2
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33845710483
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Is it dietary insulin?
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Vaarala O. Is it dietary insulin? Ann N Y Acad Sci 2006; 1079:350-359.
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Ann N Y Acad Sci
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Vaarala, O.1
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40
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33748782259
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Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin
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Mäkelä M, Vaarala O, Hermann R, et al. Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin. J Autoimmun 2006; 27:54-61.
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J Autoimmun
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Mäkelä, M.1
Vaarala, O.2
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41
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40849097522
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Association of MYO9B haplotype with type 1 diabetes
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A possible link between genetics and leaking gut in type 1 diabetes: tight-junction myosin gene polymorphism
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Santiago JL, Martinez A, Núñez C, et al. Association of MYO9B haplotype with type 1 diabetes. Hum Immunol 2008; 69:112-115. A possible link between genetics and leaking gut in type 1 diabetes: tight-junction myosin gene polymorphism.
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Hum Immunol
, vol.69
, pp. 112-115
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Santiago, J.L.1
Martinez, A.2
Núñez, C.3
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44149111801
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Vitamin D supplementation In early childhood and risk of type 1 diabetes: A systematic review and meta-analysis
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Zipitis CS, Akobeng AK. Vitamin D supplementation In early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 2008; 93:512-517.
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Arch Dis Child
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Zipitis, C.S.1
Akobeng, A.K.2
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34948901373
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Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
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Bailey R, Cooper JD, Zeitels L, et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 2007; 56:2616-2621.
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(2007)
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Bailey, R.1
Cooper, J.D.2
Zeitels, L.3
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44
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38349108166
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Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
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The study provides in-vitro evidence for the role of vitamin D in the control of intestinal permeability
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Kong J, Zhang Z, Musch MW, et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 2008; 294:G208-G216. The study provides in-vitro evidence for the role of vitamin D in the control of intestinal permeability.
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(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
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Kong, J.1
Zhang, Z.2
Musch, M.W.3
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