Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 27632-27640

  Patel, Hemal H ^a   Hamuro, Lora L ^d   Chun, Byeong Jo ^a   Kawaraguchi, Yoshitaka ^a   Quick, Alexander ^a   Rebolledo, Brian ^f   Pennypacker, Juniper ^b   Thurston, Jackie ^e   Rodriguez Pinto, Natalia ^d   Self, Christopher ^d   Olson, Gary ^d   Insel, Paul A ^c   Giles, Wayne R ^e   Taylor, Susan S ^b   Roth, David M ^a,f  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c San Diego   (United States)

^d Provid Pharmaceuticals Inc   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE; CONFOCAL MICROSCOPY; FETAL MONITORING; ORGANIC POLYMERS; PEPTIDES; PHOSPHORYLATION; PRESSURE EFFECTS; TRANSCRIPTION;

A-KINASE-ANCHORING PROTEINS; CARDIAC FUNCTIONS; CARDIAC MYOCYTES; CELL-PERMEABLE PEPTIDES; CELLULAR SYSTEM; CORONARY CIRCULATION; HEART RATES; IN-CONTROL; ISOPROTERENOL; LANGENDORFF; LEFT VENTRICULAR; MOUSE HEART; MYOCYTES; PERFUSED HEARTS; PHOSPHOLAMBAN; PROTEIN KINASE A; REGULATORY SUBUNITS; TROPONIN I; TYPE II;

HEART;

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; TRANSACTIVATOR PROTEIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIBETA; PEPTIDE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CHRONOTROPISM; CONTROLLED STUDY; GENE DISRUPTION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART RATE; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BOVINAE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HEART; HEART CONTRACTION; METABOLISM; MOLECULAR GENETICS; MUSCLE CELL; PERFUSION; PERMEABILITY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION;

A KINASE ANCHOR PROTEINS; ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CATTLE; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIBETA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEART; HEART RATE; MALE; MICE; MOLECULAR SEQUENCE DATA; MUSCLE CELLS; MYOCARDIAL CONTRACTION; PEPTIDES; PERFUSION; PERMEABILITY; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; RATS; TRANSCRIPTIONAL ACTIVATION;

EID: 77956239101     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.146589     Document Type: Article

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