Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 1 56-1, 2004, Pages

  Roth, David M ^a,b   Lai, N Chin ^c   Gao, Mei Hua ^c   Drumm, Jeffery D ^c   Jimenez, Jesus ^a   Feramisco, James R ^c   Hammond, H Kirk ^a,c  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Acetylcholine; Contractility; Left ventricular; Serotonin

Indexed keywords

ACETYLCHOLINE; ADENOVIRUS VECTOR; ADENYLATE CYCLASE; ADENYLATE CYCLASE TYPE 6; GREEN FLUORESCENT PROTEIN; NITROPRUSSIDE SODIUM; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CLAMPING; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DOSE TIME EFFECT RELATION; FEMALE; GENE EXPRESSION REGULATION; GENE TRANSFER; HEART CONTRACTION; HEART LEFT VENTRICLE CONTRACTILITY; HYPOTHERMIA; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; VIRAL GENE DELIVERY SYSTEM;

ACETYLCHOLINE; ADENOVIRIDAE; ADENYLATE CYCLASE; ANIMALS; CORONARY VESSELS; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HYPOTHERMIA, INDUCED; INDICATORS AND REAGENTS; ISOENZYMES; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; NITRIC OXIDE DONORS; NITROPRUSSIDE; SEROTONIN; VENTRICULAR FUNCTION, LEFT;

EID: 3042579812     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01009.2003     Document Type: Article

References (32)

1. Bates DO, Hillman NJ, Williams B, Neal CR, and Pocock TM. Regulation of microvascular permeability by vascular endothelial growth factors. J Anat 200: 581-597, 2002.
2. Beeri R, Guerrero JL, Supple G, Sullivan S, Levine RA, and Hajjar RJ. New efficient catheter-based system for myocardial gene delivery. Circulation 106: 1756-1759, 2002.
3. Brown JH and Taylor P. Muscarinic receptor agonists and antagonists. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics, edited by Hardman J and Limbird L. New York: McGraw-Hill, 2001, p. 155-158.
4. Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 58: 319-379, 1993.
5. Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, and Kass DA. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation 108: 2790-2797, 2003.
6. Donahue JK, Kikkawa K, Johns DC, Marban E, and Lawrence JH. Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci USA 94: 4664-4668, 1997.
7. Donahue JK, Kikkawa K, Thomas AD, Marban E, and Lawrence JH. Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin. Gene Ther 5: 630-634, 1998.
8. Feng D, Nagy JA, Hipp J, Dvorak HF, and Dvorak AM. Vesiculovacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine and serotonin. J Exp Med 183: 1981-1986, 1996.
9. Gao M, Lai N, Roth D, Zhou J, Zhu J, Anzai T, Dalton N, and Hammond H. Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. Circulation 99: 1618-1622, 1999.
10. Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, and Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med 2: 534-539, 1996.
11. Grines C, Watkins M, Helmer G, Penny W, Brinker J, Marmur J, West A, Rade J, Marott P, Hammond H, and Engler R. Angiogenic gene therapy (AGENT) trial in patients with stable angina pectoris. Circulation 105: 1291-1297, 2002.
12. Hajjar RJ, Schmidt U, Matsui T, Guerrero JL, Lee KH, Gwathmey JK, Dec GW, Semigran MJ, and Rosenzweig A. Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci USA 95: 5251-5256, 1998.
13. Hammond HK. Intracoronary gene transfer of fibroblast growth factor in experimental and clinical myocardial ischemia. Gene Ther 1: 325-342, 2002.
14. Harrison DG and Bates JN. The nitrovasodilators: new ideas about old drugs. Circulation 87: 1461-1467, 1993.
15. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J Jr, and Chien K. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med 8: 864-871, 2002.
16. Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, and Ross J Jr. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation 105: 502-508, 2002.
17. Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien K, and Ross J Jr. In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Ther 10: 1814-1820, 2003.
18. Lai N, Roth D, Gao M, Fine S, Head B, Zhu J, McKirnan D, Kwong C, Dalton N, Urasawa K, Roth D, and Hammond H. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation 102: 2396-2401, 2000.
19. Logeart D, Hatem SN, Heimburger M, Le Roux A, Michel JB, and Mercadier JJ. How to optimize in vivo gene transfer to cardiac myocytes: mechanical or pharmacological procedures? Hum Gene Ther 12: 1601-1610, 2001.
20. Logeart D, Hatem SN, Rucker-Martin C, Chossat N, Nevo N, Haddada J, Heimburger M, Perricaudet M, and Mercadier JJ. Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Hum Gene Ther 11: 1015-1022, 2000.
21. Luscher TF and Barton M. Biology of the endothelium. Clin Cardiol 20: II3-II10, 1997.
22. Michel CC and Curry FE. Microvascular permeability. Physiol Rev 79: 703-761, 1999.
23. Minshall RD, Tiruppathi C, Vogel SM, and Malik AB. Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function. Histochem Cell Biol 117: 105-112, 2002.
24. Moncada S, Palmer RMJ, and Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142, 1991.
25. Nagata K, Marban E, Lawrence JH, and Donahue JK. Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. J Mol Cell Cardiol 33: 575-580, 2001.
26. Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, and Insel PA. Quantification of signalling components and amplification in the β-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J 311: 75-80, 1995.
27. Saxena PR and Villalon CM. Cardiovascular effects of serotonin agonists and antagonists. J Cardiovasc Pharmacol 15: S17-S34, 1990.
28. 2-adrenergic receptor in the heart. Prospects for molecular ventricular assistance. Circulation 101: 408-414, 2000.
29. Stewart PL, Fuller SD, and Burnett RM. Difference imaging of adenovirus: bridging the resolution gap between X-ray crystallography and electron microscopy. EMBO J 12: 2589-2599, 1993.
30. Weig HJ, Laugwitz KL, Moretti A, Kronsbein K, Stadele C, Bruning S, Seyfarth M, Brill T, Schomig A, and Ungerer M. Enhanced cardiac contractility after gene transfer of V2 vasopressin receptors in vivo by ultrasound-guided injection or transcoronary delivery. Circulation 101: 1578-1585, 2000.
31. Wright MJ, Wightman LML, Latchman DS, and Marber MS. In vivo myocardial gene transfer: optimization and evaluation of intracoronary gene delivery in vivo. Gene Ther 8: 1833-1839, 2001.
32. Yuan Y, Granger HJ, Zawieja DC, DeFily DV, and Chilian WM. Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade. Am J Physiol Heart Circ Physiol 264: H1734-H1739, 1993.