Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 27767-27775

  Qin, Jinzhong ^a,b,c   Van Buren, Denille ^a,b   Huang, Hsien Sung ^e   Zhong, Lei ^a,c   Mostoslavsky, Raul ^a,c   Akbarian, Schahram ^e   Hock, Hanno ^a,b,c,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CHROMOSOMES; IRRADIATION; STEM CELLS; TUMORS;

BIOCHEMICAL ACTIVITY; BRAIN DEVELOPMENT; BRAIN TUMORS; CELL-CYCLE ARREST; CHROMATIN PROTEINS; CHROMATIN STRUCTURE; CYCLIN E; DOMAIN-CONTAINING PROTEINS; DOWN-REGULATION; EMBRYONIC FIBROBLASTS; EMBRYONIC STEM CELLS; FRAME FUSION; HIGHER ORDER; IN-CELL; LIFE SPAN; LYSINE 20; MOTOR CO-ORDINATION; MUTANT MICE; MUTANT PROTEINS; STATE-DEPENDENT; TRANSCRIPTIONAL REGULATOR; TRANSCRIPTIONAL REPRESSION; TRIMETHYLATION; TUMOR SUPPRESSION; TUMOR SUPPRESSORS; WESTERN-BLOT ANALYSIS;

PROTEINS;

CYCLIN E; HISTONE H4; MESSENGER RNA; NUCLEAR PROTEIN; NUCLEASE; PROTEIN L3MBTL1; UNCLASSIFIED DRUG; CHROMATIN; HISTONE; L3MBTL1 PROTEIN, MOUSE; LYSINE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; EXON; FIBROBLAST; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CELL CYCLE; CHEMISTRY; CHROMATIN; DEFICIENCY; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HELA CELL LINE; HUMAN; LONGEVITY; LYMPHOPOIESIS; METABOLISM; METHYLATION; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; RADIATION RESPONSE; SURVIVAL RATE;

MUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CELL CYCLE; CHROMATIN; CYCLIN E; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GROWTH AND DEVELOPMENT; HELA CELLS; HISTONES; HUMANS; LONGEVITY; LYMPHOPOIESIS; LYSINE; MALE; METHYLATION; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS; NUCLEAR PROTEINS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEINS;

EID: 77956235102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115410     Document Type: Article

References (48)

1. Bonasio, R., Lecona, E., and Reinberg, D. (2010) Semin. Cell Dev. Biol. 21, 221-230
2. Li, H., Fischle, W., Wang, W., Duncan, E. M., Liang, L., Murakami-Ishibe, S., Allis, C. D., and Patel, D. J. (2007) Mol. Cell 28, 677-691
3. Min, J., Allali-Hassani, A., Nady, N., Qi, C., Ouyang, H., Liu, Y., MacKenzie, F., Vedadi, M., and Arrowsmith, C. H. (2007) Nat. Struct. Mol. Biol. 14, 1229-1230
4. Trojer, P., Li, G., Sims, R. J., 3rd, Vaquero, A., Kalakonda, N., Boccuni, P., Lee, D., Erdjument-Bromage, H., Tempst, P., Nimer, S. D., Wang, Y. H., and Reinberg, D. (2007) Cell 129, 915-928
5. Lu, J., Ruhf, M. L., Perrimon, N., and Leder, P. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 9381-9386
6. Grimm, C., de Ayala Alonso, A. G., Rybin, V., Steuerwald, U., Ly-Hartig, N., Fischle, W., Müller, J., and Müller, C. W. (2007) EMBO Rep. 8, 1031-1037
7. Kim, J., Daniel, J., Espejo, A., Lake, A., Krishna, M., Xia, L., Zhang, Y., and Bedford, M. T. (2006) EMBO Rep. 7, 397-403
8. Maurer-Stroh, S., Dickens, N. J., Hughes-Davies, L., Kouzarides, T., Eisenhaber, F., and Ponting, C. P. (2003) Trends Biochem. Sci. 28, 69-74
9. Eryilmaz, J., Pan, P., Amaya, M. F., Allali-Hassani, A., Dong, A., Adams- Cioaba, M. A., Mackenzie, F., Vedadi, M., and Min, J. (2009) PLoS One 4, e7274
10. Guo, Y., Nady, N., Qi, C., Allali-Hassani, A., Zhu, H., Pan, P., Adams- Cioaba, M. A., Amaya, M. F., Dong, A., Vedadi, M., Schapira, M., Read, R. J., Arrowsmith, C. H., and Min, J. (2009) Nucleic Acids Res. 37, 2204-2210
11. Sathyamurthy, A., Allen, M. D., Murzin, A. G., and Bycroft, M. (2003) J. Biol. Chem. 278, 46968-46973
12. Wang, W. K., Tereshko, V., Boccuni, P., MacGrogan, D., Nimer, S. D., and Patel, D. J. (2003) Structure 11, 775-789
13. Grimm, C., Matos, R., Ly-Hartig, N., Steuerwald, U., Lindner, D., Rybin, V., Müller, J., and Müller, C. W. (2009) EMBO J. 28, 1965-1977
14. Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M., and Müller, J. (2006) Genes Dev. 20, 1110-1122
15. Boccuni, P., MacGrogan, D., Scandura, J. M., and Nimer, S. D. (2003) J. Biol. Chem. 278, 15412-15420
16. Li, J., Bench, A. J., Vassiliou, G. S., Fourouclas, N., Ferguson-Smith, A. C., and Green, A. R. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 7341-7346
17. MacGrogan, D., Kalakonda, N., Alvarez, S., Scandura, J. M., Boccuni, P., Johansson, B., and Nimer, S. D. (2004) Genes Chromosomes Cancer 41, 203-213
18. Campos, E. I., and Reinberg, D. (2009) Annu. Rev. Genet. 43, 559-599
19. Ruthenburg, A. J., Li, H., Patel, D. J., and Allis, C. D. (2007) Nat. Rev. Mol. Cell Biol. 8, 983-994
20. Taverna, S. D., Li, H., Ruthenburg, A. J., Allis, C. D., and Patel, D. J. (2007) Nat. Struct. Mol. Biol. 14, 1025-1040
21. Wismar, J., Löffler, T., Habtemichael, N., Vef, O., Geissen, M., Zirwes, R., Altmeyer, W., Sass, H., and Gateff, E. (1995) Mech. Dev. 53, 141-154
22. Bornemann, D., Miller, E., and Simon, J. (1996) Development 122, 1621-1630
23. Peterson, A. J., Mallin, D. R., Francis, N. J., Ketel, C. S., Stamm, J., Voeller, R. K., Kingston, R. E., and Simon, J. A. (2004) Genetics 167, 1225-1239
24. Simon, J., Chiang, A., and Bender, W. (1992) Development 114, 493-505
25. Berger, J., Kurahashi, H., Takihara, Y., Shimada, K., Brock, H. W., and Randazzo, F. (1999) Gene 237, 185-191
26. Montini, E., Buchner, G., Spalluto, C., Andolfi, G., Caruso, A., den Dunnen, J. T., Trump, D., Rocchi, M., Ballabio, A., and Franco, B. (1999) Genomics 58, 65-72
27. Koga, H., Matsui, S., Hirota, T., Takebayashi, S., Okumura, K., and Saya, H. (1999) Oncogene 18, 3799-3809
28. Arai, S., and Miyazaki, T. (2005) EMBO J. 24, 1863-1873
29. Wismar, J. (2001) FEBS Lett. 507, 119-121
30. Usui, H., Ichikawa, T., Kobayashi, K., and Kumanishi, T. (2000) Gene 248, 127-135
31. Frankenberg, S., Smith, L., Greenfield, A., and Zernicka-Goetz, M. (2007) BMC Dev. Biol. 7, 8
32. Takada, Y., Isono, K., Shinga, J., Turner, J. M., Kitamura, H., Ohara, O., Watanabe, G., Singh, P. B., Kamijo, T., Jenuwein, T., Burgoyne, P. S., and Koseki, H. (2007) Development 134, 579-590
33. Hock, H., Meade, E., Medeiros, S., Schindler, J. W., Valk, P. J., Fujiwara, Y., and Orkin, S. H. (2004) Genes Dev. 18, 2336-2341
34. Sims, J. K., Houston, S. I., Magazinnik, T., and Rice, J. C. (2006) J. Biol. Chem. 281, 12760-12766
35. Northcott, P. A., Nakahara, Y., Wu, X., Feuk, L., Ellison, D. W., Croul, S., Mack, S., Kongkham, P. N., Peacock, J., Dubuc, A., Ra, Y. S., Zilberberg, K., McLeod, J., Scherer, S. W., Sunil Rao, J., Eberhart, C. G., Grajkowska, W., Gillespie, Y., Lach, B., Grundy, R., Pollack, I. F., Hamilton, R. L., Van Meter, T., Carlotti, C. G., Boop, F., Bigner, D., Gilbertson, R. J., Rutka, J. T., and Taylor, M. D. (2009) Nat. Genet. 41, 465-472
36. Kalakonda, N., Fischle, W., Boccuni, P., Gurvich, N., Hoya-Arias, R., Zhao, X., Miyata, Y., Macgrogan, D., Zhang, J., Sims, J. K., Rice, J. C., and Nimer, S. D. (2008) Oncogene 27, 4293-4304
37. Liu, P., Jenkins, N. A., and Copeland, N. G. (2003) Genome Res. 13, 476-484
38. Eggan, K., Akutsu, H., Loring, J., Jackson-Grusby, L., Klemm, M., Rideout, W. M., 3rd, Yanagimachi, R., and Jaenisch, R. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 6209-6214
39. Rideout, W. M., 3rd, Hochedlinger, K., Kyba, M., Daley, G. Q., and Jaenisch, R. (2002) Cell 109, 17-27
40. Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., and Hock, H. (2009) Nat. Biotechnol. 27, 84-90
41. Hock, H., Hamblen, M. J., Rooke, H. M., Schindler, J. W., Saleque, S., Fujiwara, Y., and Orkin, S. H. (2004) Nature 431, 1002-1007
42. Hock, H., Hamblen, M. J., Rooke, H. M., Traver, D., Bronson, R. T., Cameron, S., and Orkin, S. H. (2003) Immunity 18, 109-120
43. Eminli, S., Foudi, A., Stadtfeld, M., Maherali, N., Ahfeldt, T., Mostoslavsky, G., Hock, H., and Hochedlinger, K. (2009) Nat. Genet. 41, 968-976
44. Schindler, J. W., Van Buren, D., Foudi, A., Krejci, O., Qin, J., Orkin, S. H., and Hock, H. (2009) Cell Stem Cell 5, 43-53
45. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Nucleic Acids Res. 11, 1475-1489
46. Fan, Y., Nikitina, T., Zhao, J., Fleury, T. J., Bhattacharyya, R., Bouhassira, E. E., Stein, A., Woodcock, C. L., and Skoultchi, A. I. (2005) Cell 123, 1199-1212
47. Brugarolas, J., Moberg, K., Boyd, S. D., Taya, Y., Jacks, T., and Lees, J. A. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1002-1007
48. Mao, J. H., Wu, D., DelRosario, R., Castellanos, A., Balmain, A., and Perez- Losada, J. (2008) Oncogene 27, 6596-6600