Polymorphism of glutathione s-transferase (GST) variants and its effect on distribution of urinary arsenic species in people exposed to low inorganic arsenic in tap water: An exploratory study

Archives of Environmental and Occupational Health

Volumn 65, Issue 3, 2010, Pages 140-147

  Caceres, Dante D ^a   Werlinger, Fabiola ^b   Orellana, Magdalena ^a   Jara, Marcelo ^c   Rocha, Rene ^a   Alvarado, Sergio A ^a,d   Luis, Quiñones ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD DE ANTOFAGASTA   (Chile)

^d UNIVERSIDAD DE TARAPACÁ   (Chile)

Author keywords

Arsenic; Exposure assessment; Genetic polymorphism; Risk assessment

Indexed keywords

GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE S-TRANSFERASE T1; GLUTATHIONE TRANSFERASE; GSTO1 PROTEIN, HUMAN; ORGANOARSENIC DERIVATIVE; ARSENIC; TAP WATER;

ANALYSIS; CHILE; CROSS-SECTIONAL STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; METABOLISM; NONPARAMETRIC TEST; POLYMERASE CHAIN REACTION; URINE; WATER SUPPLY; YOUNG ADULT; AGED; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; ENZYME POLYMORPHISM; PRIORITY JOURNAL; URINE LEVEL; WATER CONTAMINATION;

ARSENICALS; CHILE; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; STATISTICS, NONPARAMETRIC; WATER SUPPLY; YOUNG ADULT;

EID: 77956234175     PISSN: 19338244     EISSN: 21544700     Source Type: Journal    
DOI: 10.1080/19338240903390354     Document Type: Article

References (60)

1. NRC. 2001. Arsenic in Drinking Water:2001 Update, Washington, DC:National Research Council.
2. ATSDR. 2005. “ Toxicological profile for arsenic (update) ”. In US AfTSaD, Washington, DC:Department of Health and Human Services, Public Health Service.
3. Vahter, M. 2000. Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity. Toxicol Lett., 112–113:209–217.
4. Goering, P L, Aposhian, H V, Mass, M J, Cebrian, M, Beck, B D, and Waalkes, M P. 1999. The enigma of arsenic carcinogenesis:role of metabolism. Toxicol Sci., 49:5–14.
5. Vahter, M. 2002. Mechanisms of arsenic biotransformation. Toxicology,:181–182. 211–217.
6. Tseng, C H. 2009. A review on environmental factors regulating arsenic methylation in humans. Toxicol Appl Pharmacol., 235:338–350.
7. Valenzuela, O L, Drobna, Z, Hernandez-Castellanos, E, Sanchez-Pena, L C, Garcia-Vargas, G G, Borja-Aburto, V H, Styblo, M, and Del Razo, L M. 2009. Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. Toxicol Appl Pharmacol., 239:200–207.
8. Schlawicke Engstrom, K, Broberg, K, Concha, G, Nermell, B, Warholm, M, and Vahter, M. 2007. Genetic polymorphisms influencing arsenic metabolism:evidence from Argentina. Environ Health Perspect., 115:599–605.
9. Ghosh, P, Banerjee, M, Giri, A K, and Ray, K. 2008. Toxicogenomics of arsenic:classical ideas and recent advances. Mutat Res., 659:293–301.
10. Moore, L E, Smith, A H, Hopenhayn-Rich, C, Biggs, M L, Kalman, D A, and Smith, M T. 1997. Decrease in bladder cell micronucleus prevalence after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomarkers Prev., 6:1051–1056.
11. Vahter, M, and Concha, G. 2001. Role of metabolism in arsenic toxicity. Pharmacol Toxicol., 89:1–5.
12. Thomas, D J, Styblo, M, and Lin, S. 2001. The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol., 176:127–144.
13. Cohen, SM, Yamamoto, S, Cano, M, and Arnold, LL. 2001. Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats. Toxicol Sci., 59:68–74.
14. Petrick, J S, Ayala-Fierro, F, Cullen, W R, Carter, D E, and Vasken Aposhian, H. 2000. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes. Toxicol Appl Pharmacol., 163:203–207.
15. Styblo, M, Del Razo, L M, Vega, L. 2000. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch Toxicol., 74:289–299.
16. Styblo, M, Drobna, Z, Jaspers, I, Lin, S, and Thomas, D J. 2002. The role of biomethylation in toxicity and carcinogenicity of arsenic:a research update. Environ Health Perspect., 110 (Suppl 5):767–771.
17. Steinmaus, C, Yuan, Y, Kalman, D, Atallah, R, and Smith, A H. 2005. Intraindividual variability in arsenic methylation in a U.S. population. Cancer Epidemiol Biomarkers Prev., 14:919–924.
18. Vasken Aposhian, H, Zakharyan, R A, Avram, M D, Sampayo-Reyes, A, and Wollenberg, M L. 2004. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicol Appl Pharmacol., 198:327–335.
19. Harada, S, Abei, M, Tanaka, N, Agarwal, D P, and Goedde, H W. 1987. Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance. Hum Genet., 75:322–325.
20. Board, P, Coggan, M, Johnston, P, Ross, V, Suzuki, T, and Webb, C L. 1990. Genetic heterogeneity of the human glutathione transferase:a complex of gene families. Pharmacol Ther., 48:1357–1339.
21. Chiou, H Y, Hsueh, Y M, Hsieh, L L. 1997. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mutat Res., 386:197–207.
22. Yu, L, Kalla, K, Guthrie, E, Vidrine, A, and Klimecki, W T. 2003. Genetic variation in genes associated with arsenic metabolism:glutathione S-transferase omega 1–1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. Environ Health Perspect., 111:1421–1427.
23. Strange, R C, Spiteri, M A, Ramachandran, S, and Fryer, A A. 2001. Glutathione-S-transferase family of enzymes. Mutat Res., 482:21–26.
24. Bredschneider, M, Klein, K, Murdter, T E, Marx, C, Eichelbaum, M, Nussler, A K, Neuhaus, P, Zanger, U M, and Schwab, M. 2002. Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver:consequences for enzyme expression and busulfan conjugation. Clin Pharmacol Ther., 71:479–487.
25. Hopenhayn-Rich, C, Biggs, M L, Smith, A H, Kalman, D A, and Moore, L E. 1996. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ Health Perspect., 104:620–628.
26. Hopenhayn-Rich, C, Biggs, M L, Kalman, D A, Moore, L E, and Smith, A H. 1996. Arsenic methylation patterns before and after changing from high to lower concentrations of arsenic in drinking water. Environ Health Perspect., 104:1200–1207.
27. Del Razo, L M, Aguilar, C, Sierra-Santoyo, A, and Cebrian, M E. 1999. Interference in the quantitation of methylated arsenic species in human urine. J Anal Toxicol., 23:103–107.
28. Chen, Y C, Amarasiriwardena, C J, Hsueh, Y M, and Christiani, D C. 2002. Stability of arsenic species and insoluble arsenic in human urine. Cancer Epidemiol Biomarkers Prev., 11:1427–1433.
29. Loffredo, C A, Aposhian, H V, Cebrian, M E, Yamauchi, H, and Silbergeld, E K. 2003. Variability in human metabolism of arsenic. Environ Res., 92:85–91.
30. Tanaka-Kagawa, T, Jinno, H, Hasegawa, T. 2003. Functional characterization of two variant human GSTO 1–1s (Ala140Asp and Thr217Asn). Biochem Biophys Res Commun., 301:516–520.
31. Vahter, M, Concha, G, Nermell, B, Nilsson, R, Dulout, F, and Natarajan, A T. 1995. A unique metabolism of inorganic arsenic in native Andean women. Eur J Pharmacol., 293 (4):455–462.
32. Hopenhayn-Rich, C, Smith, A H, and Goeden, H M. 1993. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Environ Res., 60:161–177.
33. Caceres, D D, Pino, P, Montesinos, N, Atalah, E, Amigo, H, and Loomis, D. 2005. Exposure to inorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean population. Environ Res., 98:151–159.
34. Quiñones, L, Lucas, D, Godoy, J. 2001. CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. Cancer Lett., 174:35–44.
35. Caceres, D D, Iturrieta, J, Acevedo, C, Huidobro, C, Varela, N, and Quinones, L. 2005. Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk:exploring some gene-gene and gene-environment interactions. Eur J Epidemiol., 20:79–88.
36. Miller, S A, Dykes, D D, and Polesky, H F. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res., 16:1215
37. Buratti, M, Calzaferri, G, Caravelli, G, Colombi, A, Maroni, M, and Foa, V. 1984. Significance of arsenic metabolic forms in urine. Part I:Chemical speciation. Int J Environ Anal Chem., 17:25–34.
38. Chen, Y C, Guo, Y L, Su, H J. 2003. Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med., 45:241–248.
39. Chen, Y C, Su, H J, Guo, Y L, Hsueh, Y M, Smith, T J, Ryan, L M, Lee, M S, and Christiani, D C. 2003. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control, 14:303–310.
40. Buchet, J P, Lauwerys, R, and Roels, H. 1981. Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers. Int Arch Occup Environ Health, 48:111–118.
41. Newman, D, and Price, C. 1999. “ Renal function and nitrogen metabolites ”. In Clinical Practice in Correctional Medicine, 3rd ed. Edited by:Burtis, C A, and Ashwood, E R. 1204–1270. Philadelphia:Saunders
42. Concha, G, Vogler, G, Nermell, B, and Vahter, M. 2002. Intra-individual variation in the metabolism of inorganic arsenic. Int Arch Occup Environ Health, 75:576–580.
43. IPCS. 2001. “ Arsenic and arsenic compounds ”. In Environmental Health Criteria 2001, 224Geneva:WHO.
44. Lindberg, A L, Ekstrom, E C, Nermell, B. 2008. Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environ Res., 106:110–120.
45. STATA. 2007. Intercooled STATA for Windows, 10 ed, College Station, TX:STATA Corporation.
46. Quinones, L, Berthou, F, Varela, N, Simon, B, Gil, L, and Lucas, D. 1999. Ethnic susceptibility to lung cancer:differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations. Cancer Lett., 141:167–171.
47. Lee, K, Caceres, D, Varela, N, Csendes, D A, Rios, R H, and Quinones, S L. 2006. [Allelic variants of cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers]. Rev Med Chil., 134:1107–1115.
48. Perez-Pastene, C, Graumann, R, Diaz-Grez, F. 2007. Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component. Neurosci Lett., 418:181–185.
49. Marcos, R, Martinez, V, Hernandez, A. 2006. Metabolic profile in workers occupationally exposed to arsenic:role of GST polymorphisms. J Occup Environ Med., 48:334–341.
50. Buchet, J P, Lauwerys, R, and Roels, H. 1981. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int Arch Occup Environ Health, 48:71–79.
51. Hsueh, Y M, Hsu, M K, Chiou, H Y, Yang, M H, Huang, C C, and Chen, C J. 2002. Urinary arsenic speciation in subjects with or without restriction from seafood dietary intake. Toxicol Lett., 133:83–91.
52. Steinmaus, C, Moore, L E, Shipp, M. 2007. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. J Toxicol Environ Health A, 70:159–170.
53. Smith, A H, Arroyo, A P, Mazumder, D N. 2000. Arsenic-induced skin lesions among Atacameno people in Northern Chile despite good nutrition and centuries of exposure. Environ Health Perspect., 108:617–620.
54. Smith, A H, Goycolea, M, Haque, R, and Biggs, M L. 1998. Marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water. Am J Epidemiol., 147:660–669.
55. Aposhian, H V, Arroyo, A, Cebrian, M E. 1997. DMPS-arsenic challenge test. I:Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate. J Pharmacol Exp Ther., 282:192–200.
56. Chen, Y C, Xu, L, Guo, Y L. 2004. Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in south-western Taiwan:a preliminary study. Biomarkers, 9:386–394.
57. Hsu, L I, Chiu, A W, Huan, S K. 2008. SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. Toxicol Appl Pharmacol., 228:144–155.
58. Ghosh, P, Basu, A, Mahata, J. 2006. Cytogenetic damage and genetic variants in the individuals susceptible to arsenic-induced cancer through drinking water. Int J Cancer, 118:2470–2478.
59. Lin, G F, Du, H, Chen, J G. 2007. Glutathione S-transferases M1 and T1 polymorphisms and arsenic content in hair and urine in two ethnic clans exposed to indoor combustion of high arsenic coal in Southwest Guizhou, China. Arch Toxicol., 81:545–551.
60. McCarty, K M, Ryan, L, Houseman, E A. 2007. A case-control study of GST polymorphisms and arsenic related skin lesions. Environ Health, 6:1–10.