Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity

Toxicology Letters

Volumn 112-113, Issue , 2000, Pages 209-217

  Vahter, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Arsenic metabolism; Methyltransferases; Species; Variation

Indexed keywords

ARSENIC; CACODYLIC ACID; METHANEARSONIC ACID; METHYLTRANSFERASE;

CHIMPANZEE; CONFERENCE PAPER; DOG; DRUG EXCRETION; DRUG TOXICITY; DRUG TRANSFORMATION; GENETIC POLYMORPHISM; HAMSTER; HUMAN; MARMOSET; METHYLATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE; TOXICOKINETICS;

ANIMALS; ARSENIC; BIOTRANSFORMATION; HUMANS; METHYLATION; METHYLTRANSFERASES; POLYMORPHISM, GENETIC; SPECIES SPECIFICITY;

EID: 12744278865     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00271-4     Document Type: Conference Paper

References (60)

1. Aksoy S., Raftogianis R., Weinshilboum R. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. Biochem. Biophys. Res. Commun. 219:1996;548-554.
2. Aposhian H.V., Zakharyan R., Wu Y., Healy S., Aposhian M.M. Enzymatic methylation of arsenic compounds: II-an overview. Abernathy C.O., Calderon R.L., Chappell W.R. Arsenic. Exposure and Health Effects. 1997;296-321 Chapman and Hall, London.
3. Brouwer O.F., Onkenhout W., Edelbroek P.M., de Kom J.F.M., de Wolff F.A., Peters A.C.B. Increased neurotoxicity of arsenic in methylenetetrahydrofolate reductase deficiency. Clin. Neurol. Neurosurg. 94:1992;307-310.
4. Buchet J.P., Lauwerys R. Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man. Arch. Toxicol. 57:1985;125-129.
5. Buchet J.P., Lauwerys R. Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol. Biochem. Pharmacol. 37:1988;3149-3153.
6. Buchet J.P., Lauwerys R., Roels H. Comparison of the urinary excretion of arsenic metabolites after a single dose of sodium arsenite, monomethylarsonate or dimethylarsinate in man. Int. Arch. Occup. Environ. Health. 48:1981;71-79.
7. Chiou H.-Y., Hsueh Y.-M., Hsieh L.-L., Hsu L.-I., Hsu Y.-H., Hsieh F.-I., Wei M.-L., Chen H.-C., Yang H.-T., Leu L.-C., Chu T.-H., Chen-Wu C., Yang M.-H., Chen C.-J. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mutat. Res. 386:1997;197-207.
8. Concha G., Vogler G., Nermell B., Vahter M. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect. 106:1998a;355-359.
9. Concha G., Vogler G., Lezcano D., Nermell B., Vahter M. Exposure to inorganic arsenic metabolites during early human development. Toxicol. Sci. 44:1998b;185-190.
10. Concha G.G., Vogler G., Nermell B., Vahter M. Low arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water. Int. Arch. Occup. Environ. Health. 71:1998c;42-46.
11. Crecelius E., Yager J. Intercomparison of analytical methods for arsenic speciation in human urine. Environ. Health Perspect. 105:1997;650-653.
12. Del Razo L.M., Garcia-Vargas G.G., Vargas H., Albores A., Gonsebatt M.E., Montero R., Ostrosky-Wegman P., Kelsh M., Cebrián M.E. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism: a pilot study. Arch. Toxicol. 71(4):1997;211-217.
13. Ganesan V., Johnson A., Connelly A., Eckhardt S., Surtees R.A. Guanidinoacetate methyltransferase deficiency: new clinical features. Ped. Neurol. 17:1997;155-157.
14. Healy S.M., Casarez E.A., Ayalafierro F., Aposhian H.V. Enzymatic methylation of arsenic compounds: V - arsenite methyltransferase activity in tissues of mice. Toxicol. Appl. Pharmacol. 148:1998a;65-70.
15. Healy S.M., Casarez E.A., Ayalafierro F., Aposhian H.V. Enzymatic methylation of arsenic compounds: VI - Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro. Toxicol. Appl. Pharmacol. 152:1998b;366-375.
16. Hopenhayn-Rich C., Smith A.H., Goeden H.M. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Environ. Res. 60:1993;161-177.
17. Hopenhayn-Rich C., Biggs M.L., Smith A.H., Kalman D.A., Moore L.E. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ. Health Perspect. 104:1996;620-628.
18. Hsu K.-H., Froines J.R., Chen C.-J. Studies of arsenic ingestion from drinking-water in northeastern Taiwan: chemical speciation and urinary metabolites. Abernathy C.O., Calderon R.L., Chappell W.R. Arsenic Exposure and Health Effects II. 1997;190-209 Chapman and Hall, New York.
19. Hsueh Y.M., Cheng G.S., Wu M.M., Kuo T.L., Chen C.J. Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutrional status. Br. J. Cancer. 71:1995;109-114.
20. Hughes M.F., Kenyon E.M. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration. J. Toxicol. Environ. Health. 53(2):1998;95-112.
21. IARC, 1980. Arsenic and arsenic compounds. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some Metals and Metallic Compounds, vol. 23. International Agency for Research on Cancer, Lyon, pp. 39-141.
22. Kosnett M.J., Becker C.E. Dimercaptosuccinic acid: utility in acute and chronic arsenic poisoning. Vet. Hum. Toxicol. 30:1988;369.
23. Kreppel H., Bauman J., Liu J., McKim J.M. Jr, Klaassen C.D. Induction of metallothionein by arsenicals in mice. Fundam. Appl. Toxicol. 20:1993;184-189.
24. Krynetski E.Y., Tai H.L., Yates C.R., Fessing M.Y., Loennechen T., Schuetz J.D., Relling M.V., Evans W.E. Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. Pharmacogenetics. 6:1996;279-290.
25. Kurttio P., Komulainen H., Hakala E., Kahelin H., Pekkanen J. Urinary excretion of arsenic species after exposure to arsenic present in drinking water. Arch. Environ. Contam. Toxicol. 34:1998;297-305.
26. Lerman S.A., Clarkson T.W., Gerson R.J. Arsenic uptake and metabolism by liver cells is dependent on arsenic oxidation state. Chem. Biol. Interact. 45:1983;401-406.
27. Lucas, F., 1998. Acute and chronic toxicity assessment of MSMA and DSMA. Book of Posters. Third International Conference on Arsenic Exposure and Health Effects, San Diego.
28. 3. Its significance for the duration of BAL therapy. Clin. Toxicol. 18:1981;1067-1075.
29. Marafante E., Vahter M. The effect of methyltransferase inhibition on the metabolism of (74As) arsenite in mice and rabbits. Chem. Biol. Interact. 50:1984;49-57.
30. Marafante E., Vahter M., Envall J. The role of the methylation in the detoxication of arsenate in the rabbit. Chem. Biol. Interact. 56:1985;225-238.
31. Marafante E., Vahter M., Norin H., Envall J., Sandström M., Christakopoulos A., Ryhage R. Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7:1987;111-117.
32. Moore M.M., Harrington-Brock K., Doerr C.L. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. 386:1997;279-290.
33. National Research Council, 1999. Risk assessment of arsenic in drinking water. Subcommittee on arsenic in drinking water, National Academy Press, Washington DC, pp. 263.
34. Oya-Ohta Y., Kaise T., Ochi T. Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction. Mutat. Res. 357:1996;123-129.
35. Rasmussen R.E., Menzel D.B. Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines. Mutat. Res. 386:1997;299-306.
36. Sakurai T., Kaise T., Matsubara C. Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms. Chem. Res. Toxicol. 11:1998;273-283.
37. Scheller T., Orgacka H., Szumlaski C.L., 'Weinshilboum R.M. Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity inbred strains. Pharmacogenetics. 6:1996;43-53.
38. Scott M.C., Van Loon J.A., Weinshilboum R.M. Pharmacogenetics of N-methylation: heritability of human erythrocyte histamine N-methyltransferase activity. Clin. Pharmacol. Ther. 43:1988;256-262.
39. Stockler S., Isbrandt D., Hanefeld F., Schmidt B., Figura K. Guanidinoacetate methyl-transferase deficiency: the first inborn error of creatine metabolism in man. Am. J. Hum. Genet. 58:1996;914-922.
40. Styblo M., Serves S.V., Cullen W.R., Thomas D.J. Comparative inhibition of yeast glutathione reductase by arsenicals and arseothiols. Chem. Res. Toxicol. 10:1997;27-33.
41. Styblo, M., Del Razo, L.M., LeCluyse, E.L., Hamilton, G.A., Thomas, D.J., Wange, Cullen, W.R., 1999. Metabolism of arsenic in primary cultures of human and rat hepatocytes, Chem. Res. Toxicol. 12, 560-565.
42. Tam G.K.H., Charbonneau S.M., Bryce F., Lacroix G. Separation of arsenic metabolites in dog plasma and urine following intravenous injection of 74As. Anal. Biochem. 86:1978;505-511.
43. Tam G.K.H., Charbonneau S.M., Bryce F., Pomroy C., Sandi E. Metabolism of inorganic arsenic (74As) in humans following oral ingestion. Toxicol. Appl. Pharmacol. 50:1979;319-322.
44. Thompson D.J. A chemical hypothesis for arsenic methylation in mammals. Chem. Biol. Interact. 88:1993;89-114.
45. Tseng W.P. Effects and dose-response relationships of skin cancer and Blackfoot disease with arsenic. Environ. Health Perspect. 19:1977;109-119.
46. Vahter M. Arsenic. Clarkson T.W., Friberg L., Nordberg G.F., Sager P.R. Biological Monitoring of Toxic Metals. 1988;303-321 Plenum Press, New York.
47. Vahter M. Species differences in the metabolism of arsenic compounds. Appl. Organomet. Chem. 8:1994;175-182.
48. Vahter, M., 1999a. Variation in human metabolism of arsenic. In: Abernathy, C.O., Calderon, R.L., Chappell, W.R. (Eds.), Arsenic. Exposure and Health Effects. Chapman and Hall, New York. In press.
49. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog. 82:1999b;69-88.
50. Vahter M., Envall J. In vivo reduction of arsenate in mice and rabbits. Environ. Res. 32:1983;14-24.
51. Vahter M., Marafante E. Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits. Chem. Biol. Interact. 47:1983;29-44.
52. Vahter M., Marafante E. Reduction and binding of arsenate in marmoset monkeys. Arch. Toxicol. 57:1985;119-124.
53. Vahter M., Marafante E. Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit. Toxicol. Lett. 37:1987;41-46.
54. Vahter M., Marafante E. In vivo methylation and detoxication of arsenic. Craig P.J., Glockling F. The Biological Alkylation of Heavy Elements. 1988;105 Royal Society of Chemistry, London.
55. Vahter M., Marafante E., Dencker L. Tissue distribution and retention of 74As-dimethylarsinic acid in mice and rats. Arch. Environ. Contam. Toxicol. 13:1984;259-264.
56. Vahter M., Couch R., Nermell B., Nilsson R. Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133:1995;262-268.
57. Yan L., Otterness D.M., Craddock T.L., Weinshilboum R.M. Mouse liver nicotinamide N-methyltransferase: cDNA cloning, expression, and nucleotide sequence polymorphisms. Biochem. Pharmacol. 54:1997;1139-1149.
58. Yates C.R., Krynetski E.Y., Loennechen T., Fessing M.Y., Tai H.L., Pui C.H., Relling M.V., Evans W.E. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 126:1997;608-614.
59. Zakharyan R.A., Wu Y., Bogdan G.M., Aposhian H.V. Enzymatic methylation of arsenic compounds. I: Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem. Res. Toxicol. 8:1995;1029-1038.
60. Zaldivar R., Ghai G.L. Clinical epidemiological studies on chronic arsenic poisoning in children in adults, including observations on children with high- and low-intake of dietary arsenic. Zentrabl. Bakteriol. [B]. 170:1980;409-421.