A review on environmental factors regulating arsenic methylation in humans

Toxicology and Applied Pharmacology

Volumn 235, Issue 3, 2009, Pages 338-350

  Tseng, Chin Hsiao ^a,b,c,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Arsenic metabolism; Environmental exposure; Human health; Toxicology; Water pollutants

Indexed keywords

ALCOHOL; ARSENIC; ARSENOBETAINE; BETA CAROTENE; BETAINE; CACODYLIC ACID; CHELATING AGENT; CHOLINE; CREATININE; CYANOCOBALAMIN; DIMETHYLARSINOUS ACID; ESTROGEN; FOLIC ACID; METHANEARSONIC ACID; S ADENOSYLMETHIONINE; TRIMETHYLARSINE OXIDE; UNCLASSIFIED DRUG; UNITHIOL;

ALCOHOL CONSUMPTION; ARSENIC METABOLISM; BANGLADESH; BODY FAT; BODY MASS; BREAST FEEDING; COFFEE; COOKING; DIET; DNA METHYLATION; DNA SYNTHESIS; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ESTROGEN ACTIVITY; ETHNIC DIFFERENCE; GROUPS BY AGE; HEREDITY; HUMAN; INDIVIDUALIZATION; INTRAINDIVIDUAL VARIABILITY; KIDNEY FUNCTION; METABOLISM; METHYLATION; NUTRITIONAL STATUS; PREGNANT WOMAN; REVIEW; RICE; SEA FOOD; SEAWEED; SEX DIFFERENCE; SMOKING; STORAGE; TEA; URINARY EXCRETION; URINE VOLUME; WATER POLLUTANT;

ARSENIC; ARSENIC POISONING; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MALE; METHYLATION; PREGNANCY; RISK FACTORS;

EID: 60749108568     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.016     Document Type: Review

References (124)

1. Ahmad S.A., Sayed M.H., Barua S., Khan M.H., Faruquee M.H., Jalil A., Hadi S.A., and Talukder H.K. Arsenic in drinking water and pregnancy outcomes. Environ. Health Perspect. 109 (2001) 629-631
2. Alam M.G., Allinson G., Stagnitti F., Tanaka A., and Westbrooke M. Arsenic contamination in Bangladesh groundwater: a major environmental and social disaster. Int. J. Environ. Health Res. 12 (2002) 235-253
3. Aposhian H.V., Zakharyan R.A., Avram M.D., Kopplin M.J., and Wollenberg M.L. Oxidation and detoxification of trivalent arsenic species. Toxicol. Appl. Pharmacol. 193 (2003) 1-8
4. Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu. Rev. Pharmacol. Toxicol. 37 (1997) 397-419
5. ATSDR. Toxicological Profile for Arsenic. TP-92/02 (1993), Agency for Toxic Substances and Disease Registry, U.S. Department of Health & Human Services, Atlanta, GA
6. Bae M., Watanabe C., Inaoka T., Sekiyama M., Sudo N., Bokul M.H., and Ohtsuka R. Arsenic in cooked rice in Bangladesh. Lancet 360 (2002) 1839-1840
7. Bredfeldt T.G., Jagadish B., Eblin K.E., Mash E.A., and Gandolfi A.J. Monomethylarsonous acid induces transformation of human bladder cells. Toxicol. Appl. Pharmacol. 216 (2006) 69-79
8. Buchet J.P., Lauwerys R., and Roels H. Comparison of several methods for the determination of arsenic compounds in water and in urine. Their application for the study of arsenic metabolism and for the monitoring of workers exposed to arsenic. Int. Arch. Occup. Environ. Health 46 (1980) 11-29
9. Calderon R.L., Hudgens E., Le X.C., Schreinemachers D., and Thomas D.J. Excretion of arsenic in urine as a function of exposure to arsenic in drinking water. Environ. Health Perspect. 107 (1999) 663-667
10. Centeno J.A., Tseng C.H., Van der Voet G.B., and Finkelman R.B. Global impacts of geogenic arsenic: a medical geology research case. AMBIO 36 (2007) 78-81
11. Chen Y.C., Amarasiriwardena C.J., Hsueh Y.M., and Christiani D.C. Stability of arsenic species and insoluble arsenic in human urine. Cancer Epidemiol. Biomarkers Prev. 11 (2002) 1427-1433
12. Chen Y.C., Guo Y.L., Su H.J., Hsueh Y.M., Smith T.J., Ryan L.M., Lee M.S., Chao S.C., Lee J.Y., and Christiani D.C. Arsenic methylation and skin cancer risk in southwestern Taiwan. J. Occup. Environ. Med. 45 (2003) 241-248
13. Chiou H.Y., Hsueh Y.M., Hsieh L.L., Hsu L.I., Hsu Y.H., Hsieh F.I., Wei M.L., Chen H.C., Yang H.T., Leu L.C., Chu T.H., Chen-Wu C., Yang M.H., and Chen C.J. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mutat. Res. 386 (1997) 197-207
14. Chowdhury U.K., Rahman M.M., Sengupta M.K., Lodh D., Chanda C.R., Roy S., Quamruzzaman Q., Tokunaga H., Ando M., and Chakraborti D. Pattern of excretion of arsenic compounds [arsenite, arsenate, MMA(V), DMA(V)] in urine of children compared to adults from an arsenic exposed area in Bangladesh. J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng. 38 (2003) 87-113
15. Chung C.J., Huang C.J., Pu Y.S., Su C.T., Huang Y.K., Chen Y.T., and Hsueh Y.M. Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area. Toxicol. Appl. Pharmacol. 226 (2008) 14-21
16. Chung J.S., Kalman D.A., Moore L.E., Kosnett M.J., Arroyo A.P., Beeris M., Mazumder D.N., Hernandez A.L., and Smith A.H. Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water. Environ. Health Perspect. 110 (2002) 729-733
17. Cohen S.M., Arnold L.L., Eldan M., Lewis A.S., and Beck B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol. 36 (2006) 99-133
18. Concha G., Nermell B., and Vahter M. Spatial and temporal variations in arsenic exposure via drinking-water in northern Argentina. J. Health Popul. Nutr. 24 (2006) 317-326
19. Concha G., Nermell B., and Vahter M.V. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect. 106 (1998) 355-359
20. Concha G., Vogler G., Lezcano D., Nermell B., and Vahter M. Exposure to inorganic arsenic metabolites during early human development. Toxicol. Sci. 44 (1998) 185-190
21. Concha G., Vogler G., Nermell B., and Vahter M. Low-level arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water. Int. Arch. Occup. Environ. Health 71 (1998) 42-46
22. Concha G., Vogler G., Nermell B., and Vahter M. Intra-individual variation in the metabolism of inorganic arsenic. Int. Arch. Occup. Environ. Health 75 (2002) 576-580
23. Csanaky I., and Gregus Z. Species variations in the biliary and urinary excretion of arsenate, arsenite and their metabolites. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 131 (2002) 355-365
24. De Kimpe J., Cornelis R., and Vanholder R. In vitro methylation of arsenite by rabbit liver cytosol: effect of metal ions, metal chelating agents, methyltransferase inhibitors and uremic toxins. Drug. Chem. Toxicol. 22 (1999) 613-628
25. Del Razo L.M., Garcia-Vargas G.G., Garcia-Salcedo J., Sanmiguel M.F., Rivera M., Hernandez M.C., and Cebrian M.E. Arsenic levels in cooked food and assessment of adult dietary intake of arsenic in the Region Lagunera, Mexico. Food Chem. Toxicol. 40 (2002) 1423-1431
26. Del Razo L.M., Garcia-Vargas G.G., Vargas H., Albores A., Gonsebatt M.E., Montero R., Ostrosky-Wegman P., Kelsh M., and Cebrian M.E. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism. A pilot study. Arch. Toxicol. 71 (1997) 211-217
27. Del Razo L.M., Styblo M., Cullen W.R., and Thomas D.J. Determination of trivalent methylated arsenicals in biological matrices. Toxicol. Appl. Pharmacol. 174 (2001) 282-293
28. Devesa V., Macho M.L., Jalon M., Urieta I., Munoz O., Suner M.A., Lopez F., Velez D., and Montoro R. Arsenic in cooked seafood products: study on the effect of cooking on total and inorganic arsenic contents. J. Agric. Food Chem. 49 (2001) 4132-4140
29. Devesa V., Martinez A., Suner M.A., Benito V., Velez D., and Montoro R. Kinetic study of transformations of arsenic species during heat treatment. J. Agric. Food Chem. 49 (2001) 2267-2271
30. Devesa V., Martinez A., Suner M.A., Velez D., Almela C., and Montoro R. Effect of cooking temperatures on chemical changes in species of organic arsenic in seafood. J. Agric. Food Chem. 49 (2001) 2272-2276
31. Dopp E., Hartmann L.M., von Recklinghausen U., Florea A.M., Rabieh S., Zimmermann U., Shokouhi B., Yadav S., Hirner A.V., and Rettenmeier A.W. Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-/genotoxicity in fibroblasts and hepatoma cells. Toxicol. Sci. 87 (2005) 46-56
32. Dopp E., von Recklinghausen U., Hartmann L.M., Stueckradt I., Pollok I., Rabieh S., Hao L., Nussler A., Katier C., Hirner A.V., and Rettenmeier A.W. Subcellular distribution of inorganic and methylated arsenic compounds in human urothelial cells and human hepatocytes. Drug Metab. Dispos. 36 (2008) 971-979
33. Fängström B., Moore S., Nermell B., Kuenstl L., Goessler W., Grandér M., Kabir I., Palm B., Arifeen S.E., and Vahter M. Breast-feeding protects against arsenic exposure in Bangladeshi infants. Environ. Health Perspect. 116 (2008) 963-969
34. Feldmann J., Lai V.W., Cullen W.R., Ma M., Lu X., and Le X.C. Sample preparation and storage can change arsenic speciation in human urine. Clin. Chem. 45 (1999) 1988-1997
35. Fischer L.M., daCosta K.A., Kwock L., Stewart P.W., Lu T.S., Stabler S.P., Allen R.H., and Zeisel S.H. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am. J. Clin. Nutr. 85 (2007) 1275-1285
36. Francesconi K.A., and Kuehnelt D. Determination of arsenic species: a critical review of methods and applications, 2000-2003. Analyst 129 (2004) 373-395
37. Francesconi K.A., Tanggaar R., McKenzie C.J., and Goessler W. Arsenic metabolites in human urine after ingestion of an arsenosugar. Clin. Chem. 48 (2002) 92-101
38. Gamble M.V., Liu X., Ahsan H., Pilsner R., Ilievski V., Slavkovich V., Parvez F., Levy D., Factor-Litvak P., and Graziano J.H. Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ. Health. Perspect. 113 (2005) 1683-1688
39. Gamble M.V., Liu X., Slavkovich V., Pilsner J.R., Ilievski V., Factor-Litvak P., Levy D., Alam S., Islam M., Parvez F., Ahsan H., and Graziano J.H. Folic acid supplementation lowers blood arsenic. Am. J. Clin. Nutr. 86 (2007) 1202-1209
40. Gamble M.V., and Liu X. Urinary creatinine and arsenic metabolism [Letter]. Environ. Health Perspect. 113 (2005) A442
41. Ghosh P., Banerjee M., Giri A.K., and Ray K. Toxicogenomics of arsenic: classical ideas and recent advances. Mutat. Res. 659 (2008) 293-301
42. Haque R., Mazumder D.N., Samanta S., Ghosh N., Kalman D., Smith M.M., Mitra S., Santra A., Lahiri S., Das S., De B.K., and Smith A.H. Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Epidemiology 14 (2003) 174-182
43. Hay G., Johnston C., Whitelaw A., Trygg K., and Refsum H. Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants. Am. J. Clin. Nutr. 88 (2008) 105-114
44. Hayakawa T., Kobayashi Y., Cui X., and Hirano S. A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt 19. Arch. Toxicol. 79 (2005) 183-191
45. Heck J.E., Gamble M.V., Chen Y., Graziano J.H., Slavkovich V., Parvez F., Baron J.A., Howe G.R., and Ahsan H. Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh. Am. J. Clin. Nutr. 85 (2007) 1367-1374
46. Hernández A., and Marcos R. Genetic variations associated with interindividual sensitivity in the response to arsenic exposure. Pharmacogenomics 9 (2008) 1113-1132
47. Hinwood A.L., Sim M.R., de Klerk N., Drummer O., Gerostamoulos J., and Bastone E.B. Are 24-hour urine samples and creatinine adjustment required for analysis of inorganic arsenic in urine in population studies?. Environ. Res. 88 (2002) 219-224
48. Hong K.H., Keen C.L., Mizuno Y., Johnston K.E., and Tamura T. Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats. J. Nutr. Biochem. 11 (2000) 165-169
49. Hopenhayn C., Ferreccio C., Browning S.R., Huang B., Peralta C., Gibb H., and Hertz-Picciotto I. Arsenic exposure from drinking water and birth weight. Epidemiology 14 (2003) 593-602
50. Hopenhayn C., Huang B., Christian J., Peralta C., Ferreccio C., Atallah R., and Kalman D. Profile of urinary arsenic metabolites during pregnancy. Environ. Health Perspect. 111 (2003) 1888-1891
51. Hopenhayn-Rich C., Biggs M.L., Kalman D.A., Moore L.E., and Smith A.H. Arsenic methylation patterns before and after changing from high to lower concentrations of arsenic in drinking water. Environ. Health Perspect. 104 (1996) 1200-1207
52. Hopenhayn-Rich C., Biggs M.L., Smith A.H., Kalman D.A., and Moore L.E. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ. Health Perspect. 104 (1996) 620-628
53. Hopenhayn-Rich C., Smith A.H., and Goeden H.M. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Environ. Res. 60 (1993) 161-177
54. Hsueh Y.M., Chiou H.Y., Huang Y.L., Wu W.L., Huang C.C., Yang M.H., Lue L.C., Chen G.S., and Chen C.J. Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Cancer Epidemiol. Biomarkers. Prev. 6 (1997) 589-596
55. Hsueh Y.M., Huang Y.L., Huang C.C., Wu W.L., Chen H.M., Yang M.H., Lue L.C., and Chen C.J. Urinary levels of inorganic and organic arsenic metabolites among residents in an arseniasis-hyperendemic area in Taiwan. J. Toxicol. Environ. Health A. 54 (1998) 431-444
56. Huang Y.K., Huang Y.L., Hsueh Y.M., Yang M.H., Wu M.M., Chen S.Y., Hsu L.I., Chen C.J. 2008a Arsenic exposure, urinary arsenic speciation, and the incidence of urothelial carcinoma: a twelve-year follow-up study. 19:829-839.
57. Huang Y.K., Pu Y.S., Chung C.J., Shiue H.S., Yang M.H., Chen C.J., and Hsueh Y.M. Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility. Food Chem. Toxicol. 46 (2008) 929-938
58. Huang Y.K., Tseng C.H., Huang Y.L., Yang M.H., Chen C.J., and Hsueh Y.M. Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. Toxicol. Appl. Pharmacol. 218 (2007) 135-142
59. Ilcol Y.O., Ozbek R., Hamurtekin E., and Ulus I.H. Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk. J. Nutr. Biochem. 16 (2005) 489-499
60. Kalman D.A., Hughes J., van Belle G., Burbacher T., Bolgiano D., Coble K., Mottet N.K., and Polissar L. The effect of variable environmental arsenic contamination on urinary concentrations of arsenic species. Environ. Health Perspect. 89 (1990) 145-151
61. Kurttio P., Komulainen H., Hakala E., Kahelin H., and Pekkanen J. Urinary excretion of arsenic species after exposure to arsenic present in drinking water. Arch. Environ. Contam. Toxicol. 34 (1998) 297-305
62. Kurttio P., Pukkala E., Kahelin H., Auvinen A., and Pekkanen J. Arsenic concentrations in well water and risk of bladder and kidney cancer in Finland. Environ. Health Perspect. 107 (1999) 705-710
63. Lai V.W., Sun Y., Ting E., Cullen W.R., and Reimer K.J. Arsenic speciation in human urine: are we all the same?. Toxicol. Appl. Pharmacol. 198 (2004) 297-306
64. Le X.C., Ma M., Cullen W.R., Aposhian H.V., Lu X., and Zheng B. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ. Health Perspect. 108 (2000) 1015-1018
65. Li L., Ekström E.C., Goessler W., Lönnerdal B., Nermell B., Yunus M., Rahman A., El Arifeen S., Persson L.A., and Vahter M. Nutritional status has marginal influence on the metabolism of inorganic arsenic in pregnant Bangladeshi women. Environ. Health Perspect. 116 (2008) 315-321
66. Lindberg A.L., Ekstrom E.C., Nermell B., Rahman M., Lonnerdal B., Persson L.A., and Vahter M. Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environ. Res. 106 (2008) 110-120
67. Lindberg A.L., Kumar R., Goessler W., Thirumaran R., Gurzau E., Koppova K., Rudnai P., Leonardi G., Fletcher T., and Vahter M. Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. Environ. Health Perspect. 115 (2007) 1081-1086
68. Lindberg A.L., Rahman M., Persson L.A., and Vahter M. The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure. Toxicol. Appl. Pharmacol. 230 (2008) 9-16
69. Loffredo C.A., Aposhian H.V., Cebrian M.E., Yamauchi H., and Silbergeld E.K. Variability in human metabolism of arsenic. Environ. Res. 92 (2003) 85-91
70. Ma M., and Le X.C. Effect of arsenosugar ingestion on urinary arsenic speciation. Clin. Chem. 44 (1998) 539-550
71. Maki-Paakkanen J., Kurttio P., Paldy A., and Pekkanen J. Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water. Environ. Mol. Mut. 32 (1998) 301-313
72. Maloney C.A., Hay S.M., and Rees W.D. Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus. Br. J. Nutr. 97 (2007) 1090-1098
73. Mandal B.K., and Suzuki K.T. Arsenic around the world: a review. Talanta 58 (2002) 201-235
74. Meza M.M., Kopplin M.J., Burgess J.L., and Gandolfi A.J. Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico. Environ. Res. 96 (2004) 119-126
75. Milton A.H., Smith W., Rahman B., Hasan Z., Kulsum U., Dear K., Rakibuddin M., and Ali A. Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh. Epidemiology 16 (2005) 82-86
76. Mitra S.R., Mazumder D.N., Basu A., Block G., Haque R., Samanta S., Ghosh N., Smith M.M., von Ehrenstein O.S., and Smith A.H. Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India. Environ. Health Perspect. 112 (2004) 1104-1109
77. Nermell B., Lindberg A.L., Rahman M., Berglund M., Persson L.A., El Arifeen S., and Vahter M. Urinary arsenic concentration adjustment factors and malnutrition. Environ. Res. 106 (2008) 212-218
78. Paiva L., Martínez V., Creus A., Quinteros D., and Marcos R. Evaluation of micronucleus frequencies in blood lymphocytes from smelting plant workers exposed to arsenic. Environ. Mol. Mutagen. 49 (2008) 200-205
79. Peraza M.A., Ayala-Fierro F., Barber D.S., Casarez E., and Rael L.T. Effects of micronutrients on metal toxicity. Environ. Health Perspect. 106 Suppl 1 (1998) 203-216
80. Pu Y.S., Yang S.M., Huang Y.K., Chung C.J., Huang S.K., Chiu A.W., Yang M.H., Chen C.J., and Hsueh Y.M. Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure. Toxicol. Appl. Pharmacol. 218 (2007) 99-106
81. Rahman A., Vahter M., Ekstrom E.C., Rahman M., Golam Mustafa A.H., Wahed M.A., Yunus M., and Persson L.A. Association of arsenic exposure during pregnancy with fetal loss and infant death: a cohort study in Bangladesh. Am. J. Epidemiol. 165 (2007) 1389-1396
82. Raml R., Goessler W., Traar P., Ochi T., and Francesconi K.A. Novel thioarsenic metabolites in human urine after ingestion of an arsenosugar, 2′, 3′-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-beta-d-riboside. Chem. Res. Toxicol. 18 (2005) 1444-1450
83. Rosado J.L., Ronquillo D., Kordas K., Rojas O., Alatorre J., Lopez P., Garcia-Vargas G., Del Carmen Caamano M., Cebrian M.E., and Stoltzfus R.J. Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ. Health Perspect. 115 (2007) 1371-1375
84. Rossman T.G. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res. 533 (2003) 37-65
85. Schläwicke Engström K., Broberg K., Concha G., Nermell B., Warholm M., and Vahter M. Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina. Environ. Health Perspect. 115 (2007) 599-605
86. Smith A.H., Arroyo A.P., Mazumder D.N., Kosnett M.J., Hernandez A.L., Beeris M., Smith M.M., and Moore L.E. Arsenic-induced skin lesions among Atacameno people in Northern Chile despite good nutrition and centuries of exposure. Environ. Health Perspect. 108 (2000) 617-620
87. Smith E., Juhasz A.L., Weber J., and Naidu R. Arsenic uptake and speciation in rice plants grown under greenhouse conditions with arsenic contaminated irrigation water. Sci. Total. Environ. 392 (2008) 277-283
88. Spiegelstein O., Lu X., Le X.C., Troen A., Selhub J., Melnyk S., James S.J., and Finnell R.H. Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol. Lett. 145 (2003) 167-174
89. Stanger O. Physiology of folic acid in health and disease. Curr. Drug. Metab. 3 (2002) 211-223
90. Steinmaus C., Bates M.N., Yuan Y., Kalman D., Atallah R., Rey O.A., Biggs M.L., Hopenhayn C., Moore L.E., Hoang B.K., and Smith A.H. Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. J. Occup. Environ. Med. 48 (2006) 478-488
91. Steinmaus C., Carrigan K., Kalman D., Atallah R., Yuan Y., and Smith A.H. Dietary intake and arsenic methylation in a U.S. population. Environ. Health Perspect. 113 (2005) 1153-1159
92. Steinmaus C., Moore L.E., Shipp M., Kalman D., Rey O.A., Biggs M.L., Hopenhayn C., Bates M.N., Zheng S., Wiencke J.K., and Smith A.H. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. J. Toxicol. Environ. Health A 70 (2007) 159-170
93. Steinmaus C., Yuan Y., Kalman D., Atallah R., and Smith A.H. Intraindividual variability in arsenic methylation in a U.S. population. Cancer Epidemiol. Biomarkers. Prev. 14 (2005) 919-924
94. Styblo M., Del Razo L.M., LeCluyse E.L., Hamilton G.A., Wang C., Cullen W.R., and Thomas D.J. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chem. Res. Toxicol. 12 (1999) 560-565
95. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., and Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74 (2000) 289-299
96. Suh J.R., Herbig A.K., and Stover P.J. New perspectives on folate catabolism. Annu. Rev. Nutr. 21 (2001) 255-282
97. Suwazono Y.A.A., Alfven T., Jarup L., and Vahter M. Creatinine versus specific gravity adjusted urinary cadmium concentrations. Biomarkers 10 (2005) 117-126
98. Tice R.R., Yager J.W., Andrews P., and Crecelius E. Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite. Mutat. Res. 386 (1997) 315-334
99. Tokunaga H., Roychowdhury T., Chandraskaran N., Uchino T., and Ando M. Urinary arsenic species in an arsenic-affected area of West Bengal, India. Appl. Organomet. Chem. 16 (2002) 406-414
100. Tseng C.H. Blackfoot disease and arsenic: a never-ending story. J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev. 23 (2005) 55-74
101. Tseng C.H., Huang Y.K., Huang Y.L., Chung C.J., Yang M.H., Chen C.J., and Hsueh Y.M. Arsenic exposure, urinary arsenic speciation and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Toxicol. Appl. Pharmacol. 206 (2005) 299-308
102. Tseng C.H. Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 25 (2007) 1-22
103. Tseng C.H. Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans. J. Environ. Biol. 28 (2007) 349-357
104. Ueland P.M., Holm P.I., and Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin. Chem. Lab. Med. 43 (2005) 1069-1075
105. Vahter M., Concha G., Nermell B., Nilsson R., Dulout F., and Natarajan A.T. A unique metabolism of inorganic arsenic in native Andean women. Eur. J. Pharmacol. 293 (1995) 455-462
106. Vahter M., and Marafante E. Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit. Toxicol. Lett. 37 (1987) 41-46
107. Vahter M. 2002 Mechanisms of arsenic biotransformation. Toxicology. 181-182:211-217.
108. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog. 82 Pt 1 (1999) 69-88
109. Vahter M.E., Li L., Nermell B., Rahman A., El Arifeen S., Rahman M., Persson L.A., and Ekström E.C. Arsenic exposure in pregnancy: a population-based study in Matlab, Bangladesh. J. Health Popul. Nutr. 24 (2006) 236-245
110. Vahter M.E. Interactions between arsenic-induced toxicity and nutrition in early life. J. Nutr. 137 (2007) 2798-2804
111. von Ehrenstein O.S., Poddar S., Yuan Y., Mazumder D.G., Eskenazi B., Basu A., Hira-Smith M., Ghosh N., Lahiri S., Haque R., Ghosh A., Kalman D., Das S., and Smith A.H. Children's intellectual function in relation to arsenic exposure. Epidemiology 18 (2007) 44-51
112. Wallace J.M., Bonham M.P., Strain J., Duffy E.M., Robson P.J., Ward M., McNulty H., Davidson P.W., Myers G.J., Shamlaye C.F., Clarkson T.W., Molloy A.M., Scott J.M., and Ueland P.M. Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study. Am. J. Clin. Nutr. 87 (2008) 391-397
113. Walton F.S., Waters S.B., Jolley S.L., LeCluyse E.L., Thomas D.J., and Styblo M. Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chem. Res. Toxicol. 16 (2003) 261-265
114. Wang S.X., Wang Z.H., Cheng X.T., Li J., Sang Z.P., Zhang X.D., Han L.L., Qiao X.Y., Wu Z.M., and Wang Z.Q. Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China. Environ. Health Perspect. 115 (2007) 643-647
115. Warner M.L., Moore L.E., Smith M.T., Kalman D.A., Fanning E., and Smith A.H. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada. Cancer Epidemiol. Biomarkers Prev. 3 (1994) 583-590
116. Wasserman G.A., Liu X., Parvez F., Ahsan H., Factor-Litvak P., van Geen A., Slavkovich V., LoIacono N.J., Cheng Z., Hussain I., Momotaj H., and Graziano J.H. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ. Health Perspect. 112 (2004) 1329-1333
117. Wasserman G.A., Liu X., Parvez F., Ahsan H., Factor-Litvak P., Kline J., van Geen A., Slavkovich V., Loiacono N.J., Levy D., Cheng Z., and Graziano J.H. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ. Health Perspect. 115 (2007) 285-289
118. WHO. Guidelines for Drinking Water Quality: Recommendations vol. 1 (1993), World Health Organization, Geneva
119. Yamamura Y., and Yamauchi H. Arsenic metabolites in hair, blood and urine in workers exposed to arsenic trioxide. Ind. Health 18 (1980) 203-210
120. Yang C.Y., Chang C.C., Tsai S.S., Chuang H.Y., Ho C.K., and Wu T.N. Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in northeastern Taiwan. Environ. Res. 91 (2003) 29-34
121. Yu R.C., Hsu K.H., Chen C.J., and Froines J.R. Arsenic methylation capacity and skin cancer. Cancer Epidemiol. Biomarkers Prev. 9 (2000) 1259-1262
122. Zakharyan R.A., Sampayo-Reyes A., Healy S.M., Tsaprailis G., Board P.G., Liebler D.C., and Aposhian H.V. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chem. Res. Toxicol. 14 (2001) 1051-1057
123. Zeisel S.H. Choline: critical role during fetal development and dietary requirements in adults. Annu. Rev. Nutr. 26 (2006) 229-250
124. Zeisel S.H. The fetal origins of memory: the role of dietary choline in optimal brain development. J. Pediatr. 149 suppl 5 (2006) S131-S136