Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-βE22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27144-27158

  Hernandez Guillamon, Mar ^b,d   Mawhirt, Stephanie ^a   Fossati, Silvia ^a   Blais, Steven ^a   Pares, Mireia ^b   Penalba, Anna ^b   Boada, Merce ^b   Couraud, Pierre Olivier ^c   Neubert, Thomas A ^a   Montaner, Joan ^b   Ghiso, Jorge ^a   Rostagno, Agueda ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c INSTITUT COCHIN   (France)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY ARRAYS; APOPTOSIS; BASEMENT MEMBRANE; BLOOD-BRAIN BARRIER; CEREBRAL AMYLOID ANGIOPATHY; HUMAN BRAIN; IMMUNOPRECIPITATIONS; IN-SITU; IN-VITRO; IN-VIVO; INTERNAL STANDARDS; ISCHEMIC STROKES; MASS SPECTROMETRY ANALYSIS; MATRIX; MATRIX METALLOPROTEINASE-2; METALLOPROTEASES; PEPTIDE CONFORMATION; PROTECTIVE EFFECTS; PROTEOLYTIC FRAGMENTS; WESTERN BLOTS; ZYMOGRAPHY;

BLOOD; BRAIN; CELL DEATH; DEGRADATION; DEUTERIUM; GELS; GENE EXPRESSION; GLYCOPROTEINS; LINEAR TRANSFORMATIONS; MASS SPECTROMETRY; PEPTIDES; SELF ASSEMBLY; TOXICITY;

ENDOTHELIAL CELLS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-16]; ENZYME ANTIBODY; GELATINASE A; INTERSTITIAL COLLAGENASE; MUTANT PROTEIN; RECOMBINANT ENZYME; SHORT HAIRPIN RNA; THIOFLAVINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; BINDING ASSAY; BRAIN BLOOD VESSEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENSITOMETRY; DOT BLOT ANALYSIS; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; GELATIN ZYMOGRAPHY; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROVASCULATURE; MULTIPLEX ANTIBODY ARRAY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FIBRILLAR ASSEMBLY; PROTEIN VARIANT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; ZYMOGRAPHY;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HUMANS; INTRACRANIAL HEMORRHAGES; MATRIX METALLOPROTEINASE 2; MUTATION, MISSENSE; PEPTIDES;

EID: 77956232864     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.135228     Document Type: Article

References (81)

1. Yamada, M. (2000) Neuropathology 20, 8-22
2. Kalaria, R. N. (1992) Brain Metab. Rev. 4, 226-260
3. Castaño, E. M., Prelli, F., Soto, C., Beavis, R., Matsubara, E., Shoji, M., and Frangione, B. (1996) J. Biol. Chem. 271, 32185-32191
4. Rensink, A. A., de Waal, R. M., Kremer, B., and Verbeek, M. M. (2003) Brain Res. Rev. 43, 207-223
5. Vonsattel, J. P., Myers, R. H., Hedley-Whyte, E. T., Ropper, A. H., Bird, E. D., and Richardson, E. P., Jr. (1991) Ann. Neurol. 30, 637-649
6. Mandybur, T. I. (1986) J. Neuropathol. Exp. Neurol. 45, 79-90
7. O'Donnell, H. C., Rosand, J., Knudsen, K. A., Furie, K. L., Segal, A. Z., Chiu, R. I., Ikeda, D., and Greenberg, S. M. (2000) N. Engl. J. Med. 342, 240-245
8. Maia, L. F., Vasconcelos, C., Seixas, S., Magalhães, R., and Correia, M. (2006) Cerebrovasc. Dis. 22, 155-161
9. Greenberg, S. M., Gurol, M. E., Rosand, J., and Smith, E. E. (2004) Stroke 35, 2616-2619
10. Brayne, C., Matthews, F. E., Xuereb, J. H., Broome, J. C., McKenzie, J., Rossi, M., Ince, P. G., McKeith, I. G., Lowe, J., Esiri, M. M., and Morris, J. H. (2001) Lancet 357, 169-175
11. Rostagno, A., and Ghiso, J. (2008) Neurodegener. Dis. 5, 173-175
12. Kumar-Singh, S. (2009) Int. J. Mol. Sci. 10, 1872-1895
13. Revesz, T., Holton, J. L., Lashley, T., Plant, G., Frangione, B., Rostagno, A., and Ghiso, J. (2009) Acta Neuropathol. 118, 115-130
14. Rostagno, A., Holton, J. L., Lashley, T., Revesz, T., and Ghiso, J. (2010) Cell. Mol. Life Sci. 67, 581-600
15. Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I., van Duinen, S. G., Bots, G. T., Luyendijk, W., and Frangione, B. (1990) Science 248, 1124-1126
16. Van Broeckhoven, C., Haan, J., Bakker, E., Hardy, J. A., Van Hul, W., Wehnert, A., Vegter-Van der Vlis, M., and Roos, R. A. (1990) Science 248, 1120-1122
17. Bornebroek, M., Haan, J., Van Duinen, S. G., Maat-Schieman, M. L., Van Buchem, M. A., Bakker, E., Van Broeckhoven, C., and Roos, R. A. (1997) Ann. Neurol. 41, 695-698
18. Maat-Schieman, M., Roos, R., and van Duinen, S. (2005) Neuropathology 25, 288-297
19. van Duinen, S. G., Castaño, E. M., Prelli, F., Bots, G. T., Luyendijk, W., and Frangione, B. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5991-5994
20. Obici, L., Demarchi, A., de Rosa, G., Bellotti, V., Marciano, S., Donadei, S., Arbustini, E., Palladini, G., Diegoli, M., Genovese, E., Ferrari, G., Coverlizza, S., and Merlini, G. (2005) Ann. Neurol. 58, 639-644
21. Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., and Shirasawa, T. (2003) J. Biol. Chem. 278, 46179-46187
22. Davis, J., and Van Nostrand, W. E. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 2996-3000
23. Muñoz, F. J., Opazo, C., Gil-Gómez, G., Tapia, G., Fernández, V., Valverde, M. A., and Inestrosa, N. C. (2002) J. Neurosci. 22, 3081-3089
24. Eisenhauer, P. B., Johnson, R. J., Wells, J. M., Davies, T. A., and Fine, R. E. (2000) J. Neurosci. Res. 60, 804-810
25. Viana, R. J., Nunes, A. F., Castro, R. E., Ramalho, R. M., Meyerson, J., Fossati, S., Ghiso, J., Rostagno, A., and Rodrigues, C. M. (2009) Cell. Mol. Life Sci. 66, 1094-1104
26. Miravalle, L., Tokuda, T., Chiarle, R., Giaccone, G., Bugiani, O., Tagliavini, F., Frangione, B., and Ghiso, J. (2000) J. Biol. Chem. 275, 27110-27116
27. Wisniewski, T., Ghiso, J., and Frangione, B. (1991) Biochem. Biophys. Res. Commun. 179, 1247-1254
28. Van Nostrand, W. E., Melchor, J. P., and Ruffini, L. (1998) J. Neurochem. 70, 216-223
29. Fossati, S., Cam, J., Meyerson, J., Mezhericher, E., Romero, I. A., Couraud, P. O., Weksler, B. B., Ghiso, J., and Rostagno, A. (2010) FASEB J. 24, 229-241
30. Montaner, J., Molina, C. A., Monasterio, J., Abilleira, S., Arenillas, J. F., Ribó, M., Quintana, M., and Alvarez-Sabín, J. (2003) Circulation 107, 598-603
31. Alvarez-Sabín, J., Delgado, P., Abilleira, S., Molina, C. A., Arenillas, J., Ribó, M., Santamarina, E., Quintana, M., Monasterio, J., and Montaner, J. (2004) Stroke 35, 1316-1322
32. Abilleira, S., Montaner, J., Molina, C. A., Monasterio, J., Castillo, J., and Alvarez-Sabín, J. (2003) J. Neurosurg. 99, 65-70
33. Backstrom, J. R., Lim, G. P., Cullen, M. J., and Tökés, Z. A. (1996) J. Neurosci. 16, 7910-7919
34. Yan, P., Hu, X., Song, H., Yin, K., Bateman, R. J., Cirrito, J. R., Xiao, Q., Hsu, F. F., Turk, J. W., Xu, J., Hsu, C. Y., Holtzman, D. M., and Lee, J. M. (2006) J. Biol. Chem. 281, 24566-24574
35. Roher, A. E., Kasunic, T. C., Woods, A. S., Cotter, R. J., Ball, M. J., and Fridman, R. (1994) Biochem. Biophys. Res. Commun. 205, 1755-1761
36. Crouch, P. J., Tew, D. J., Du, T., Nguyen, D. N., Caragounis, A., Filiz, G., Blake, R. E., Trounce, I. A., Soon, C. P., Laughton, K., Perez, K. A., Li, Q. X., Cherny, R. A., Masters, C. L., Barnham, K. J., and White, A. R. (2009) J. Neurochem. 108, 1198-1207
37. Miners, J. S., Baig, S., Palmer, J., Palmer, L. E., Kehoe, P. G., and Love, S. (2008) Brain Pathol. 18, 240-252
38. Weksler, B. B., Subileau, E. A., Perrière, N., Charneau, P., Holloway, K., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., Male, D. K., Roux, F., Greenwood, J., Romero, I. A., and Couraud, P. O. (2005) FASEB J. 19, 1872-1874
39. Rostagno, A., and Ghiso, J. (2009) Curr. Protoc. Cell Biol. Chapter 3, 3.33.31-33.33.33
40. Tomidokoro, Y., Lashley, T., Rostagno, A., Neubert, T. A., Bojsen-Møller, M., Braendgaard, H., Plant, G., Holton, J., Frangione, B., Révész, T., and Ghiso, J. (2005) J. Biol. Chem. 280, 36883-36894
41. Tomidokoro, Y., Rostagno, A., Neubert, T. A., Lu, Y., Rebeck, G. W., Frangione, B., Greenberg, S. M., and Ghiso, J. (2010) Am. J. Pathol. 176, 1841-1854
42. Solito, R., Corti, F., Fossati, S., Mezhericher, E., Donnini, S., Ghiso, J., Giachetti, A., Rostagno, A., and Ziche, M. (2009) Exp. Cell Res. 315, 385-395
43. Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Selkoe, D. J., and Teplow, D. B. (1999) J. Biol. Chem. 274, 25945-25952
44. Harper, J. D., Wong, S. S., Lieber, C. M., and Lansbury, P. T., Jr. (1999) Biochemistry 38, 8972-8980
45. Portelius, E., Zetterberg, H., Andreasson, U., Brinkmalm, G., Andreasen, N., Wallin, A., Westman-Brinkmalm, A., and Blennow, K. (2006) Neurosci. Lett. 409, 215-219
46. Gelfanova, V., Higgs, R. E., Dean, R. A., Holtzman, D. M., Farlow, M. R., Siemers, E. R., Boodhoo, A., Qian, Y. W., He, X., Jin, Z., Fisher, D. L., Cox, K. L., and Hale, J. E. (2007) Brief Funct. Genomic Proteomic 6, 149-158
47. Morelli, L., Llovera, R., Ibendahl, S., and Castaño, E. M. (2002) Neurochem. Res. 27, 1387-1399
48. Chen, K. L., Wang, S. S., Yang, Y. Y., Yuan, R. Y., Chen, R. M., and Hu, C. J. (2009) Biochem. Biophys. Res. Comm. 378, 57-61
49. Graf, K., Koehne, P., Gräfe, M., Zhang, M., Auch-Schwelk, W., and Fleck, E. (1995) Hypertension 26, 230-235
50. McCarty, J. H. (2005) Assay Drug Dev. Technol. 3, 89-95
51. Farkas, E., and Luiten, P. G. M. (2001) Prog. Neurobiol. 64, 575-611
52. Bailey, T. L., Rivara, C. B., Rocher, A. B., and Hof, P. R. (2004) Neurol. Res. 26, 573-578
53. de la Torre, J. C. (2004) Neurol. Res. 26, 517-524
54. Gorelick, P. B. (2004) Stroke 35, 2620-2622
55. Petty, M. A., and Wettstein, J. G. (2001) Brain Res. Rev. 36, 23-34
56. Rosenberg, G. A. (2009) Lancet Neurol. 8, 205-216
57. Yong, V. W., Power, C., Forsyth, P., and Edwards, D. R. (2001) Nat. Rev. Neurosci 2, 502-511
58. Rosenberg, G. A., Mun-Bryce, S., Wesley, M., and Kornfeld, M. (1990) Stroke 21, 801-807
59. Rosenberg, G. A., Estrada, E., Kelley, R. O., and Kornfeld, M. (1993) Neurosci. Lett. 160, 117-119
60. Rosenberg, G. A., Estrada, E. Y., Dencoff, J. E., and Stetler-Stevenson, W. G. (1995) Brain Res. 703, 151-155
61. Rosenberg, G. A., Kornfeld, M., Estrada, E., Kelley, R. O., Liotta, L. A., and Stetler-Stevenson, W. G. (1992) Brain Res. 576, 203-207
62. Jung, S. S., Zhang, W., and Van Nostrand, W. E. (2003) J. Neurochem. 85, 1208-1215
63. Lee, J. M., Yin, K. J., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y., and Xu, J. (2003) Ann. Neurol. 54, 379-382
64. Lee, J. M., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y., and Xu, J. (2005) J. Neurol. Sci. 229-230, 249-254
65. Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., and Rosenberg, G. A. (2007) J. Cereb. Blood Flow Metab. 27, 697-709
66. Lapchak, P. A., Chapman, D. F., and Zivin, J. A. (2000) Stroke 31, 3034-3040
67. Sumii, T., and Lo, E. H. (2002) Stroke 33, 831-836
68. Garcia-Alloza, M., Prada, C., Lattarulo, C., Fine, S., Borrelli, L. A., Betensky, R., Greenberg, S. M., Frosch, M. P., and Bacskai, B. J. (2009) J. Neurochem. 109, 1636-1647
69. Du, R., Petritsch, C., Lu, K., Liu, P., Haller, A., Ganss, R., Song, H., Vandenberg, S., and Bergers, G. (2008) Neuro Oncol. 10, 254-264
70. Frisch, S. M., Vuori, K., Ruoslahti, E., and Chan-Hui, P. Y. (1996) J. Cell Biol. 134, 793-799
71. Ethell, D. W., Kinloch, R., and Green, D. R. (2002) Curr. Biol. 12, 1595-1600
72. Eckman, E. A., Reed, D. K., and Eckman, C. B. (2001) J. Biol. Chem. 276, 24540-24548
73. Tucker, H. M., Kihiko, M., Caldwell, J. N., Wright, S., Kawarabayashi, T., Price, D., Walker, D., Scheff, S., McGillis, J. P., Rydel, R. E., and Estus, S. (2000) J. Neurosci. 20, 3937-3946
74. Liao, M. Q., Tzeng, Y. J., Chang, L. Y., Huang, H. B., Lin, T. H., Chyan, C. L., and Chen, Y. C. (2007) FEBS Lett. 581, 1161-1165
75. Morelli, L., Llovera, R., Gonzalez, S. A., Affranchino, J. L., Prelli, F., Frangione, B., Ghiso, J., and Castano, E. M. (2003) J. Biol. Chem. 278, 23221-23226
76. Tsubuki, S., Takaki, Y., and Saido, T. C. (2003) Lancet 361, 1957-1958
77. Betts, V., Leissring, M. A., Dolios, G., Wang, R., Selkoe, D. J., and Walsh, D. M. (2008) Neurobiol. Dis. 31, 442-450
78. Walsh, D. M., and Selkoe, D. J. (2007) J. Neurochem. 101, 1172-1184
79. Caughey, B., and Lansbury, P. T. J. (2003) Annu. Rev. Neurosci. 26, 267-298
80. Feng, Y., Yang, S. G., Du, X. T., Zhang, X., Sun, X. X., Zhao, M., Sun, G. Y., and Liu, R. T. (2009) Biochem. Biophys. Res. Commun. 390, 1250-1254
81. Necula, M., Breydo, L., Milton, S., Kayed, R., van der Veer, W. E., Tone, P., and Glabe, C. G. (2007) Biochemistry 46, 8850-8860