Imaging genetics in ADHD

NeuroImage

Volumn 53, Issue 3, 2010, Pages 832-838

  Durston, Sarah ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE;

ATTENTION DEFICIT DISORDER; DOPAMINERGIC SYSTEM; ELECTROENCEPHALOGRAPHY; EVENT RELATED POTENTIAL; GENE EXPRESSION; GENE FUNCTION; GENE MAPPING; GENETIC RISK; GENETIC VARIABILITY; HUMAN; IMAGING GENETICS; MOLECULAR GENETICS; MOLECULAR IMAGING; NEUROIMAGING; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; DIAGNOSTIC IMAGING; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; PHENOTYPE; RECEPTORS, DOPAMINE D4;

EID: 77956201591     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2010.02.071     Document Type: Review

References (57)

1. Almasy L., Blangero J. Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am. J. Med. Genet. 2001, 105:42-44.
2. Baehne, C.G., Ehlis, A.C., Plichta, M.M., Conzelmann, A., Pauli, P., Jacob, C., Gutknecht, L., Lesch, K.P., Fallgatter, A.J., 2009. Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals. Mol. Psychiatry 14 (11), 1032-1039.
3. Becker K., El-Faddagh M., Schmidt M.H., Esser G., Laucht M. Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms. J. Pediatr. 2008, 152:263-269.
4. Bédard AC, Schulz KP, Cook EH Jr, Fan J, Clerkin SM, Ivanov I, Halperin JM, Newcorn JH. Dopamine transporter gene variation modulates activation of striatum in youth with ADHD. Neuroimage, in press [Electronic publication ahead of print].
5. Beekman F., van der Have F. The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. Eur. J. Nucl. Med. Mol. Imaging 2007, 34(2):151-161.
6. Bellgrove M.A., O'Connell R.G., Vance A. Genetics of cognitive deficits in ADHD: clues for novel treatment methods. Exp. Rev. Neurother. 2008, 8(4):553-561.
7. Bigos K.L., Weinberger D.R. Imaging genetics-days of future past. Neuroimage 2010, 53(3):804-809.
8. Bobb A.J., Addington A.M., Sidransky E., Gornick M.C., Lerch J.P., Greenstein D.K., et al. Support for association between ADHD and two candidate genes: NET1 and DRD1. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 134(1):67-72.
9. Brookes K.J., Mill J., Guindalini C., Curran S., Xu X., Knight J., Chen C.-K., Huang Y.-S., Sethna V., Taylor E., Chen W., Breen G., Asherson P. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch. Gen. Psychiatry 2006, 63:74-81.
10. Brown A.B., Biederman J., Valera E.M., Doyle A.E., Bush G., Spencer T., Monuteaux M.C., Mick E., Whitfield-Gabrieli S., Makris N., Laviolette P.S., Oscar-Berman M., Faraone S.V., Seidman L.J. Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 153B(2):365-375.
11. Cardno A.G., Gottesman I.I. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am. J. Med. Genet. 2000, 97(1):12-17.
12. Castellanos F.X., Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat. Rev. Neurosci. 2002, 3:617-628.
13. Castellanos F.X., Lau E., Tayebi N., Lee P., Long R.E., Giedd J.N., et al. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses. Mol. Psychiatry 1998, 3(5):431-434.
14. Cheon K.A., Ryu Y.H., Kim J.W., Cho D.Y. The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. Eur. Neuropsychopharmacol. 2005, 15(1):95-101.
15. Durston S., Hulshoff Pol H.E., Schnack H.G., Buitelaar J.K., Steenhuis M.P., Minderaa R.B., Kahn R.S., van Engeland H. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J. Am. Acad. Child Adolesc. Psychiatry 2004, 43(3):332-340. http://www.ncbi.nlm.nih.gov/pubmed/15076267.
16. Durston S., Fossella J.A., Casey B.J., Hulshoff Pol H.E., Galvan A., Schnack H.G., et al. Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. Mol. Psychiatry 2005, 10(7):678-685.
17. Durston S., Mulder M., Casey B.J., Ziermans T., van Engeland H. Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder. Biol. Psychiatry 2006, 60(10):1062-1070. http://www.ncbi.nlm.nih.gov/pubmed/16712804.
18. Durston S., Fossella J.A., Mulder M.J., Casey B.J., Ziermans T.B., Vessaz M.N., et al. Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation. J. Am. Acad. Child Adolesc. Psychiatry 2008, 47(1):61-67.
19. Durston S., De Zeeuw P., Staal W.G. Imaging genetics in ADHD: a focus on cognitive control. Neurosci. Biobehav. Rev. 2009, 33(5):674-689.
20. Faraone S.V., Perlis R.H., Doyle A.E., Smoller J.W., Goralnick J.J., Holmgren M.A., Sklar P. Molecular genetics of attention-deficit/hyperactivity disorder. Biol. Psychiatry 2005, 57:1313-1323.
21. Franke B., Hoogman M., Arias Vasquez A., Heister J.G., Savelkoul P.J., Naber M., Scheffer H., Kiemeney L.A., Kan C.C., Kooij J.J., Buitelaar J.K. Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B(8):1576-1579.
22. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160(4):636-645.
23. Hamarman Fossella J., Ulger C., Brimacombe M., Dermody J. Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: a pharmacogenetic study. J. Child Adolesc. Psychopharmacol. 2004, 14(4):564-574.
24. Heiser P., Friedel S., Dempfle A., Konrad K., Smidt J., Grabarkiewicz J., Herpetz-Dahlnabb B., Remschmidt H., Hebebrand J. Molecular genetic aspects of attention-deficit/hyperactivity disorder. Neurosci. Biobehav. Rev. 2004, 28:625-641.
25. Johnson K.A., Kelly S.P., Robertson I.H., Barry E., Mulligan A., Daly M., Lambert D., McDonnell C., Connor T.J., Hawi Z., Gill M., Bellgrove M.A. Absence of the 7-repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B(6):927-937.
26. Kahn R.S., Khoury J., Nichols W.C., Lanphear B.P. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J. Pediatrics 2003, 143(1):104-110.
27. Kebir O., Tabbane K., Sengupta S., Joober R. Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies. J. Psychiatry Neurosci. 2009, 34(2):88-101.
28. Kjeldsen M.J., Corey L.A., Christensen K., Friis M.L. Epileptic seizures and syndromes in twins: the importance of genetic factors. Epilepsy Res. 2003, 55(1-2):137-146.
29. Krause J. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev. Neurother. 2008, 8(4):611-625.
30. Krause J., Dresel S.H., Krause K.H., La Fougère C., Zill P., Ackenheil M. Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. World J. Biol. Psychiatry 2006, 7(3):152-157.
31. Lenroot R.K., Giedd J.N. The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twins. Dev Psychopathol. 2008, 20(4):1161-1175. http://www.ncbi.nlm.nih.gov/pubmed/18838036.
32. Li D., Sham P.C., Owen M.J., He L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum. Mol. Genet. 2006, 15:2276-2284.
33. Loo S.K., Specter E., Smolen A., Hopfer C., Teale P.D., Reite M.L. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. J. Am. Acad. Child. Adolesc. Psychiatry 2003, 42(8):986-993.
34. Maher B.S., Marazita M.L., Ferrell R.E., Vanyukov M.M. Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis. Psychiat. Genet. 2002, 12:207-215.
35. Manor I., Tyano S., Eisenberg J., Bachner-Melman R., Kotler M., Ebstein R.P. The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA). Mol. Psychiatry 2002, 7(7):790-794.
36. Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 2006, 7(10):818-827. http://www.ncbi.nlm.nih.gov/pubmed/16988657.
37. Monuteaux M.C., Seidman L.J., Faraone S.V., Makris N., Spencer T., Valera E., Brown A., Bush G., Doyle A.E., Hughes S., Helliesen M., Mick E., Biederman J. A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B(8):1436-1441.
38. Mulder M.J., Baeyens D., Davidson M.C., Casey B.J., van den Ban E., van Engeland H., Durston S. Familial vulnerability to ADHD affects activity in the cerebellum in addition to the prefrontal systems. J. Am. Acad. Child. Adolesc. Psychiatry 2008, 47(1):68-75.
39. Neuman R.J., Lobos E., Reich W., Henderson C.A., Sun L.-W., Todd R.D. Prenatal exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol. Psychiatry 2007, 61:1320-1328.
40. Nigg J.T. Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: the state of the field and salient challenges for the coming decade. Biol. Psychiatry 2005, 57(11):1424-1435.
41. Plomp, E., van Engeland, H., Durston, S., 2009. Understanding genes, environment and their interaction in ADHD: is there a role for neuroimaging? Neurosci. 164 (1), 230-240.
42. Purper-Ouakil D., Wohl M., Mouren M.C., Verpillat P., Ades J., Gorwood P. Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder. Psychiatr. Genet. 2005, 15:53-59.
43. Rohde L.A., Roman T., Szobot C., Cunha R.D., Hutz M.H., Biederman J. Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study. Synapse 2003, 48(2):87-89.
44. Rommelse N.N., Altink M.E., Arias-Vásquez A., Buschgens C.J., Fliers E., Faraone S.V., Buitelaar J.K., Sergeant J.A., Franke B., Oosterlaan J. A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B(8):1536-1546.
45. Shaw P., Gornick M., Lerch J., Addington A., Seal J., Greenstein D., et al. Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Arch. Gen. Psychiatry 2007, 64(8):921-931.
46. Soliman F., Glatt C.E., Bath K.G., Levita L., Jones R.M., Pattwell S.S., Jing D., Tottenham N., Amso D., Somerville L.H., Voss H.U., Glover G., Ballon D.J., Liston C., Teslovich T., Van Kempen T., Lee F.S., Casey B.J. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 2010, 327(5967):863-866.
47. Spencer T.J., Biederman J., Madras B.K., Faraone S.V., Dougherty D.D., Bonab A.A., Fischman A.J. In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter. Biol. Psychiatry 2005, 1293-1300.
48. Spencer T.J., Biederman J., Madras B.K., Dougherty D.D., Bonab A.A., Livni E., Meltzer P.C., Martin J., Rauch S., Fischman A.J. Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane. Biol. Psychiatry 2007, 62:1059-1061.
49. Swanson J., Oosterlaan J., Murias M., Schuck S., Flodman P., Spence M.A., Wasdell M., Ding Y., Chi H.C., Smith M., Mann M., Carlson C., Kennedy J.L., Sergeant J.A., Leung P., Zhang Y.P., Sadeh A., Chen C., Whalen C.K., Babb K.A., Moyzis R., Posner M.I. Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(9):4754-4759.
50. Szobot C., Roman T., Cunha R., Acton P., Hutz M., Rohde L.A. Brain perfusion and dopaminergic genes in boys with attention deficit/hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 132B(1):53-58.
51. Thapar A., O'Donovan M., Owen M.J. The genetics of attention deficit hyperactivity disorder. Hum. Mol. Genet. 2005, 14:R275-R282.
52. Volkow N.D., Wang G.J., Newcorn J., Fowler J.S., Telang F., Solanto M.V., Logan J., Wong C., Ma Y., Swanson J.M., Schulz K., Pradhan K. Brain dopamine transporter levels in treatment and drug naïve adults with ADHD. Neuroimage 2007, 34(3):1182-1190.
53. Waldman I.D., Gizer I.R. The genetics of attention deficit hyperactivity disorder. Clin. Psychol. Rev. 2006, 26:396-432.
54. Waldman I.D., Rowe D.C., Abramowitz A., Kozel S.T., Mohr J.H., Sherman S.L., Cleveland H.H., Sanders M.L., Gard J.M.C., Stever C. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am. J. Hum. Genet. 1998, 63:1767-1776.
55. Wang E., Ding Y.C., Flodman P., Kidd J.R., Kidd K.K., Grady D.L. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am. J. Hum. Genet. 2004, 74:931-944.
56. Webb A.G. Introduction to Biomedical Imaging 2003, Wiley-IEEE Press, Hoboken.
57. Yang B., Chan R.C.K., Jing J., Li T., Sham P., Chen R.Y.L. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3' UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am. J. Med. Gen. B Neuropsychiatr. Genet. 2007, 144B:541-550.