Molecular mechanisms of the immunosuppressive action of cyclosporin a

International Journal of Immunopharmacology

Volumn 19, Issue 9-10, 1997, Pages 579-585

  Resch, Klaus ^a   Szamel, Marta ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cyclosporin A; Immunosuppression; Signal transduction; T cell activation; T lymphocyte

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; METHOTREXATE; PROTEIN KINASE C; RAPAMYCIN; TACROLIMUS;

CELL VIABILITY; CONFERENCE PAPER; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; IMMUNE DEFICIENCY; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE ACTIVATION; TARGET CELL;

CYCLOSPORINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PEPTIDYLPROLYL ISOMERASE; PROTEIN KINASE C; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TACROLIMUS; TRANSCRIPTION FACTORS;

EID: 0031224940     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(98)00004-6     Document Type: Conference Paper

References (57)

1. Athreya, B. H. and Cassidy, J. T. (1991) Current status of the medical treatment of children with juvenile rheumatoid arthritis. Rheum. Dis. Clin. North. Am. 17, 871-889.
2. Baeuerle, P. A. and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
3. Baumann, G., Zenke, G., Wenger, R., Hiestand, P., Quesniaux, V., Andersen, E. and Schreier, M. H. (1992) Molecular mechanisms of immunosuppression. J. Autoimmun. 5, 67-72.
4. Berry, N. and Nishizuka, Y. (1990) Protein kinase C and T cell activation. Eur. J. Biochem. 189, 205-214.
5. Bierer, B. E. (1994) Biology of cyclosporin A and FK506. Prog. Clin. Biol. Res. 390, 203-223.
6. Bierer, B. E. (1994) Cyclosporin A FK506, and rapamycin :binding to immunophilins and biological action. Chem. Immunol. 59, 128-155.
7. Bierer, B. E. (1995) Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. Proc. Assoc. Am. Physicians. 107, 28-40.
8. Bierer, B. E., Hollander, G., Fruman, D. and Burakoff, S. J. (1993) Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr. Opin. Immunol. 5, 763-773.
9. Bram, R. J. and Crabtree, G. R. (1994) Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Nature. 371, 355-358.
10. Bram, R. J., Hung, D. T., Martin, P. K., Schreiber, S. L. and Crabtree, G. R. (1993) Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol. Cell. Biol. 13, 4760-4769.
11. Cantrell, D. A. (1994) G proteins involved in lymphocyte signalling. Curr. Opin. Immunol. 6, 380-385.
12. Cantrell, D. A. (1996) T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14, 259-274.
13. Chang, J. Y., Sehgal, S. N. and Bansbach, C. C. (1991) FK506 and rapamycin : novel pharmacological probes of the immune response. TIPS. 12, 218-223.
14. Clipstone, N. A. and Crabtree, G. R. (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
15. Clipstone, N. A. and Crabtree, G. R. (1993) Calcineurin is a key signalling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann. N.Y. Acad. Sci. 696, 20-30.
16. Crabtree, G. R. (1994) NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-502.
17. Crabtree, G. R. and Clipstone, N. A. (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63, 1045-1083.
18. Erlanger, B. F. (1992) Do we know the site of action of cyclosporin? Immunol. Today 13, 487-490.
19. Frantz, B., Nordby, E. C., Bren, G., Steffan, N., Paya, C. V., Kincaid, R. L., Tocci, M. J., O'Keefe, S. J. and O'Neill, E. A. (1994) Calcineurin acts in synergy with PMA to activate IκB/MAD3, an inhibitor of NFκB. EMBO J. 13, 861-870.
20. Fraser, J. D., Straus, D. and Weiss, A. (1993) Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 14, 357-362.
21. Fruman, D. A., Burakoff, S. J. and Bierer, B. E. (1994) Immunophilins in protein folding and immunosuppression. FASEB J. 8, 391-400.
22. Granelli-Piperno, A., Nolan, P., Inaba, K. and Steinmann, R. M. (1990) The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin-2 promoter. J. Exp. Med. 172, 1869-1872.
23. Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B. and Davis, R. J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770.
24. Hug, H. and Sarre, T. F. (1993) Protein kinase C isoenzymes, divergence in signal transduction? Biochem. J. 291, 329-343.
25. Jain, J., Loh, C. and Rao, A. (1995) Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7, 333-342.
26. Jain, J., McCaffrey, P. G., Miner, Z., Kerppola, T. K., Lambert, J., Verdine, G., Curran, T. and Rao, A. (1993) The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365, 352-355.
27. Jain, J., Nalefski, E. A., McCaffrey, P. G., Johnson, R. S., Spiegelman, B. M., Papioannou, V. and Rao, A. (1994) Normal peripheral T-cell function in c-Fos-deficient mice. Mol. Cell. Biol. 14, 1566-1574.
28. Kahan, B. D. (1989) Cyclosporine. N. Engl. J. Med. 321, 1725-1737.
29. Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J. and Crabtree, G. R. (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358, 70-73.
30. Loh, C., Carew, J. A., Kim, J., Hogan, P. G. and Rao, A. (1996) T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol. Cell. Biol. 16, 3945-3954.
31. Lyakh, L., Ghosh, P. and rice, N. R. (1997) Expression of NFAT-family proteins in normal human T cells. Mol. Cel. Biol. 17, 2475-2482.
32. Mollinedo, F., Gajate, C. and Flores, I. (1994) Involvement of phospholipase D in the activation of transcription factor AP-1 in human lymphoid Jurkat cells. J. Immunol. 153, 2457-2555.
33. Morris, P. J. (1991) Cyclosporine, FK-506 and other drugs in organ transplantation. Curr. Opin. Immunol. 3, 748-751.
34. Nel, A. E., Taylor, L. K., Kumar, G. P., Gupta, S., Wang, S. C. T., Williams, K., Liao, O, Swanson, K, and Landreth, G. E. (1994) Activation of a novel serine/threonine kinase that phosphorylates c-Fos upon stimulation of T- and B-lymphocytes via antigen and cytokine receptors. J. Immunol. 152, 4347-4357.
35. Noble, S. and Markham, A. (1995) Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation. Drugs 50, 924-941.
36. O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J. and O'Neill, E. A. (1992) FK-506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357, 692-694.
37. Ochi, Y., Koizumi, T., Kobayashi, S., Pluchareon, J., Hatano, M., Takada, M., Tomita, Y. and Tokushisa, T. (1994) Analysis of II-2 gene regulation in c-Fos transgenic mice. J. Immunol. 153, 3485-3490.
38. Rao, A. (1994) NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 15, 274-281.
39. Rayat, G., Yatscoff, R., Silverman, R. and McKenna, R. (1993) A comparison of the immunosuppressive effects of cyclosporine A and cyclosporine G in vivo and in vitro. Transplantation, 55, 623-626.
40. Rooney, J. W., Hoey, T. and Glimcher, L. H. (1995) Coordinate and cooperative roles of NF-AT and AP-I in the regulation of the murine IL-4 gene. Immunity 2, 473-483.
41. Ryffel, J. B. (1989) Pharmacology of cyclosporine. VI. Cellular activation : regulation of intracellular events by cyclosporine. Phys. Rev. 41, 407-422.
42. Schreiber, S. L. (1991) Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251, 283-287.
43. Schreiber, S. L. and Crabtree, G. R. (1992) The mechanism of action of cyclosporin A and FK 506. Immunol. Today 13, 136-142.
44. Serfling, E., Avots, A. and Neumann, M. (1995) The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta. 1263, 181-200.
45. Sharma, V. K., Li, B., Khanna, A., Sehajpal, P. and Suthanthiran, M. (1994) Which way for drug-mediated immunosuppression? Curr. Opin. Immunol. 6, 784-790.
46. Sigal, N. H. and Dumont, F. J. (1992) Cyclosporin A, FK-506, and rapamycin : pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10, 519-560.
47. Stricker, K., Serfling, E., Krammer, P. H. and Falk, W. (1993) An NF-κB-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter. Eur. Immunol. 23, 1475-1480.
48. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriach-Y (1994) JNK is involved in signal integration during costimulation of T-lymphocytes. Cell 77, 727-736.
49. Su, B. and Karin, M. (1996) Mitogen activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8, 401-412.
50. Szamel, M., Rehermann, B., Krebs, B., Kurrle, B. and Resch, K. (1989) Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. J. Immunol. 143, 2806-2813.
51. Szamel, M., Bartels, F. and Resch, K. (1993) Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-β. Eur. J. Immunol. 23, 3072-3081.
52. Szamel, M. and Resch, K. (1995) T-cell antigen receptor-induced signal-transduction pathways. Activation and function of protein kinases C in T lymphocytes. Eur. J. Biochem. 228, 1-15.
53. Szamel, M., Ebel, U., Uciechowski, P., Kaever, V. and Resch, K. (1997) T cell receptor dependent signalling in human lymphocytes: cholera toxin inhibits interleukin-2 receptor expression but not interleukin-2 synthesis by preventing activation of a protein kinase C isotype, PKC-α. Biochim. Biophys. Acta. 1356, 237-248.
54. 2+ signals and immunosuppression. Nature 383, 837-840.
55. Walsh, C. T., Zydowsky, L. D. and McKeon, F. D. (1992) Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J. Biol. Chem. 267, 13115-13118.
56. Weiss, A. and Littman, D. R. (1994) Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
57. Xanthoudakis, S., Viola, J. P., Shaw, K. T., Luo, C., Wallace, J. D., Bozza, P. T., Curran, T. and Rao, A. (1996) An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272, 892-895.