메뉴 건너뛰기




Volumn 188, Issue 1, 2010, Pages 86-93

Cytotoxic role of methylglyoxal in rat retinal pericytes: Involvement of a nuclear factor-kappaB and inducible nitric oxide synthase pathway

Author keywords

Apoptosis; Inducible nitric oxide synthase; Methylglyoxal; Nuclear factor kappaB; Rat retinal pericytes

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; METHYLGLYOXAL; N6 (1 IMINOETHYL)LYSINE; PYRROLIDINE DITHIOCARBAMATE;

EID: 77956174800     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.07.002     Document Type: Article
Times cited : (26)

References (60)
  • 1
    • 13744249120 scopus 로고    scopus 로고
    • Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes
    • Cunha-Vaz J., Bernardes R. Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes. Prog. Retin. Eye Res. 2005, 24:355-377.
    • (2005) Prog. Retin. Eye Res. , vol.24 , pp. 355-377
    • Cunha-Vaz, J.1    Bernardes, R.2
  • 2
    • 0037407314 scopus 로고    scopus 로고
    • Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats
    • Roy S., Sato T., Paryani G., Kao R. Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats. Diabetes 2003, 52:1229-1234.
    • (2003) Diabetes , vol.52 , pp. 1229-1234
    • Roy, S.1    Sato, T.2    Paryani, G.3    Kao, R.4
  • 3
    • 0027396022 scopus 로고
    • The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal
    • Phillips S.A., Thornalley P.J. The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal. Eur. J. Biochem. 1993, 212:101-105.
    • (1993) Eur. J. Biochem. , vol.212 , pp. 101-105
    • Phillips, S.A.1    Thornalley, P.J.2
  • 4
    • 0033571012 scopus 로고    scopus 로고
    • Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    • Thornalley P.J., Langborg A., Minhas H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 1999, 344(Pt 1):109-116.
    • (1999) Biochem. J. , vol.344 , Issue.PART 1 , pp. 109-116
    • Thornalley, P.J.1    Langborg, A.2    Minhas, H.S.3
  • 5
    • 0028453652 scopus 로고
    • Lilly Lecture 1993. Glycation and diabetic complications
    • Brownlee M. Lilly Lecture 1993. Glycation and diabetic complications. Diabetes 1994, 43:836-841.
    • (1994) Diabetes , vol.43 , pp. 836-841
    • Brownlee, M.1
  • 6
    • 0028292698 scopus 로고
    • Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications
    • McLellan A.C., Thornalley P.J., Benn J., Sonksen P.H. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin. Sci. 1994, 87:21-29.
    • (1994) Clin. Sci. , vol.87 , pp. 21-29
    • McLellan, A.C.1    Thornalley, P.J.2    Benn, J.3    Sonksen, P.H.4
  • 9
    • 17644387768 scopus 로고    scopus 로고
    • Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography
    • Randell E.W., Vasdev S., Gill V. Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography. J. Pharmacol. Toxicol. Methods 2005, 51:153-157.
    • (2005) J. Pharmacol. Toxicol. Methods , vol.51 , pp. 153-157
    • Randell, E.W.1    Vasdev, S.2    Gill, V.3
  • 10
    • 23844502010 scopus 로고    scopus 로고
    • Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins
    • Zeng J., Davies M.J. Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins. Chem. Res. Toxicol. 2005, 18:1232-1241.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1232-1241
    • Zeng, J.1    Davies, M.J.2
  • 13
  • 14
    • 1542333426 scopus 로고    scopus 로고
    • Methylglyoxal induces apoptosis mediated by reactive oxygen species in bovine retinal pericytes
    • Kim J., Son J.W., Lee J.A., Oh Y.S., Shinn S.H. Methylglyoxal induces apoptosis mediated by reactive oxygen species in bovine retinal pericytes. J. Korean Med. Sci. 2004, 19:95-100.
    • (2004) J. Korean Med. Sci. , vol.19 , pp. 95-100
    • Kim, J.1    Son, J.W.2    Lee, J.A.3    Oh, Y.S.4    Shinn, S.H.5
  • 15
    • 0035882511 scopus 로고    scopus 로고
    • Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process
    • Du J., Suzuki H., Nagase F., Akhand A.A., Ma X.Y., Yokoyama T., Miyata T., Nakashima I. Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic. Biol. Med. 2001, 31:469-478.
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 469-478
    • Du, J.1    Suzuki, H.2    Nagase, F.3    Akhand, A.A.4    Ma, X.Y.5    Yokoyama, T.6    Miyata, T.7    Nakashima, I.8
  • 18
    • 33847078455 scopus 로고    scopus 로고
    • Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2
    • Chan W.H., Wu H.J., Shiao N.H. Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2. J. Cell. Biochem. 2007, 100:1056-1069.
    • (2007) J. Cell. Biochem. , vol.100 , pp. 1056-1069
    • Chan, W.H.1    Wu, H.J.2    Shiao, N.H.3
  • 19
    • 35248871238 scopus 로고    scopus 로고
    • Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis
    • Cantero A.V., Portero-Otin M., Ayala V., Auge N., Sanson M., Elbaz M., Thiers J.C., Pamplona R., Salvayre R., Negre-Salvayre A. Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis. FASEB J. 2007, 21:3096-3106.
    • (2007) FASEB J. , vol.21 , pp. 3096-3106
    • Cantero, A.V.1    Portero-Otin, M.2    Ayala, V.3    Auge, N.4    Sanson, M.5    Elbaz, M.6    Thiers, J.C.7    Pamplona, R.8    Salvayre, R.9    Negre-Salvayre, A.10
  • 20
    • 0025883342 scopus 로고
    • Nitric oxide: physiology, pathophysiology, and pharmacology
    • Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991, 43:109-142.
    • (1991) Pharmacol. Rev. , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 21
    • 0030881495 scopus 로고    scopus 로고
    • Nitric oxide in health and disease of the nervous system
    • Yun H.Y., Dawson V.L., Dawson T.M. Nitric oxide in health and disease of the nervous system. Mol. Psychiatry 1997, 2:300-310.
    • (1997) Mol. Psychiatry , vol.2 , pp. 300-310
    • Yun, H.Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 22
    • 0028092958 scopus 로고
    • Nitric oxide synthases: roles, tolls, and controls
    • Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994, 78:915-918.
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 23
    • 0034810383 scopus 로고    scopus 로고
    • Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus
    • Abu El-Asrar A.M, Desmet S., Meersschaert A., Dralands L., Missotten L., Geboes K. Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus. Am. J. Ophthalmol. 2001, 132:551-556.
    • (2001) Am. J. Ophthalmol. , vol.132 , pp. 551-556
    • Abu El-Asrar, A.M.1    Desmet, S.2    Meersschaert, A.3    Dralands, L.4    Missotten, L.5    Geboes, K.6
  • 24
    • 0034524671 scopus 로고    scopus 로고
    • Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability
    • Carmo A., Cunha-Vaz J.G., Carvalho A.P., Lopes M.C. Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability. Nitric Oxide 2000, 4:590-596.
    • (2000) Nitric Oxide , vol.4 , pp. 590-596
    • Carmo, A.1    Cunha-Vaz, J.G.2    Carvalho, A.P.3    Lopes, M.C.4
  • 25
    • 0036319333 scopus 로고    scopus 로고
    • Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine
    • Du Y., Smith M.A., Miller C.M., Kern T.S. Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. J. Neurochem. 2002, 80:771-779.
    • (2002) J. Neurochem. , vol.80 , pp. 771-779
    • Du, Y.1    Smith, M.A.2    Miller, C.M.3    Kern, T.S.4
  • 26
    • 0036334679 scopus 로고    scopus 로고
    • Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat
    • Ellis E.A., Guberski D.L., Hutson B., Grant M.B. Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat. Nitric Oxide 2002, 6:295-304.
    • (2002) Nitric Oxide , vol.6 , pp. 295-304
    • Ellis, E.A.1    Guberski, D.L.2    Hutson, B.3    Grant, M.B.4
  • 27
    • 34547674399 scopus 로고    scopus 로고
    • Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    • Zheng L, Du Y., Miller C., Gubitosi-Klug R.A., Ball S., Berkowitz B.A., Kern T.S. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia 2007, 50:1987-1996.
    • (2007) Diabetologia , vol.50 , pp. 1987-1996
    • Zheng, L.1    Du, Y.2    Miller, C.3    Gubitosi-Klug, R.A.4    Ball, S.5    Berkowitz, B.A.6    Kern, T.S.7
  • 28
    • 0036306098 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    • Romeo G., Liu W.H., Asnaghi V., Kern T.S., Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 2002, 51:2241-2248.
    • (2002) Diabetes , vol.51 , pp. 2241-2248
    • Romeo, G.1    Liu, W.H.2    Asnaghi, V.3    Kern, T.S.4    Lorenzi, M.5
  • 29
    • 0142180047 scopus 로고    scopus 로고
    • Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants
    • Kowluru R.A., Koppolu P., Chakrabarti S., Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic. Res. 2003, 37:1169-1180.
    • (2003) Free Radic. Res. , vol.37 , pp. 1169-1180
    • Kowluru, R.A.1    Koppolu, P.2    Chakrabarti, S.3    Chen, S.4
  • 30
    • 0032100679 scopus 로고    scopus 로고
    • Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells
    • Zhang H., Chen X., Teng X., Snead C., Catravas J.D. Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells. Biochem. Pharmacol. 1998, 55:1873-1880.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1873-1880
    • Zhang, H.1    Chen, X.2    Teng, X.3    Snead, C.4    Catravas, J.D.5
  • 32
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 1994, 269:4705-4708.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705-4708
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 33
    • 0030573989 scopus 로고    scopus 로고
    • Cloning and sequencing of the proximal promoter of the rat iNOS gene: activation of NFkappaB is not sufficient for transcription of the iNOS gene in rat mesangial cells
    • Beck K.F., Sterzel R.B. Cloning and sequencing of the proximal promoter of the rat iNOS gene: activation of NFkappaB is not sufficient for transcription of the iNOS gene in rat mesangial cells. FEBS Lett. 1996, 394:263-267.
    • (1996) FEBS Lett. , vol.394 , pp. 263-267
    • Beck, K.F.1    Sterzel, R.B.2
  • 35
    • 44649189401 scopus 로고    scopus 로고
    • The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy
    • Cai J., Kehoe O., Smith G.M., Hykin P., Boulton M.E. The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2008, 49:2163-2171.
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49 , pp. 2163-2171
    • Cai, J.1    Kehoe, O.2    Smith, G.M.3    Hykin, P.4    Boulton, M.E.5
  • 36
    • 0025002208 scopus 로고
    • Simplified methods for consistent and selective culture of bovine retinal endothelial cells and pericytes
    • Capetandes A., Gerritsen M.E. Simplified methods for consistent and selective culture of bovine retinal endothelial cells and pericytes. Invest. Ophthalmol. Vis. Sci. 1990, 31:1738-1744.
    • (1990) Invest. Ophthalmol. Vis. Sci. , vol.31 , pp. 1738-1744
    • Capetandes, A.1    Gerritsen, M.E.2
  • 37
    • 10744222460 scopus 로고    scopus 로고
    • Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2)
    • Kondo T., Hosoya K., Hori S., Tomi M., Ohtsuki S., Takanaga H., Nakashima E., Iizasa H., Asashima T., Ueda M., Obinata M., Terasaki T. Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2). Cell Struct. Funct. 2003, 28:145-153.
    • (2003) Cell Struct. Funct. , vol.28 , pp. 145-153
    • Kondo, T.1    Hosoya, K.2    Hori, S.3    Tomi, M.4    Ohtsuki, S.5    Takanaga, H.6    Nakashima, E.7    Iizasa, H.8    Asashima, T.9    Ueda, M.10    Obinata, M.11    Terasaki, T.12
  • 38
    • 37749019976 scopus 로고    scopus 로고
    • Strengthening tight junctions of retinal microvascular endothelial cells by pericytes under normoxia and hypoxia involving angiopoietin-1 signal way
    • Wang Y.L., Hui Y.N., Guo B., Ma J.X. Strengthening tight junctions of retinal microvascular endothelial cells by pericytes under normoxia and hypoxia involving angiopoietin-1 signal way. Eye 2007, 21:1501-1510.
    • (2007) Eye , vol.21 , pp. 1501-1510
    • Wang, Y.L.1    Hui, Y.N.2    Guo, B.3    Ma, J.X.4
  • 39
    • 20044386906 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide
    • Cacicedo J.M., Benjachareowong S., Chou E., Ruderman N.B., Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes 2005, 54:1838-1845.
    • (2005) Diabetes , vol.54 , pp. 1838-1845
    • Cacicedo, J.M.1    Benjachareowong, S.2    Chou, E.3    Ruderman, N.B.4    Ido, Y.5
  • 40
    • 0031915402 scopus 로고    scopus 로고
    • Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity
    • Berkowitz B.A., Lukaszew R.A., Mullins C.M., Penn J.S. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998, 39:391-396.
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 391-396
    • Berkowitz, B.A.1    Lukaszew, R.A.2    Mullins, C.M.3    Penn, J.S.4
  • 41
    • 77953330776 scopus 로고    scopus 로고
    • KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo
    • Kim O.S., Kim J., Kim C.S., Kim N.H., Kim J.S. KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo. J. Ethnopharmacol. 2010, 129:285-292.
    • (2010) J. Ethnopharmacol. , vol.129 , pp. 285-292
    • Kim, O.S.1    Kim, J.2    Kim, C.S.3    Kim, N.H.4    Kim, J.S.5
  • 43
    • 0036394373 scopus 로고    scopus 로고
    • Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction
    • Koga K., Yamagishi S., Okamoto T., Inagaki Y., Amano S., Takeuchi M., Makita Z. Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction. Int. J. Clin. Pharmacol. Res. 2002, 22:13-17.
    • (2002) Int. J. Clin. Pharmacol. Res. , vol.22 , pp. 13-17
    • Koga, K.1    Yamagishi, S.2    Okamoto, T.3    Inagaki, Y.4    Amano, S.5    Takeuchi, M.6    Makita, Z.7
  • 44
    • 12244266481 scopus 로고    scopus 로고
    • Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes
    • Miura J., Yamagishi S., Uchigata Y., Takeuchi M., Yamamoto H., Makita Z., Iwamoto Y. Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes. J. Diabetes Complications 2003, 17:16-21.
    • (2003) J. Diabetes Complications , vol.17 , pp. 16-21
    • Miura, J.1    Yamagishi, S.2    Uchigata, Y.3    Takeuchi, M.4    Yamamoto, H.5    Makita, Z.6    Iwamoto, Y.7
  • 45
    • 33744959529 scopus 로고    scopus 로고
    • Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions
    • Miller A.G., Smith D.G., Bhat M., Nagaraj R.H. Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions. J. Biol. Chem. 2006, 281:11864-11871.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11864-11871
    • Miller, A.G.1    Smith, D.G.2    Bhat, M.3    Nagaraj, R.H.4
  • 46
    • 22444449069 scopus 로고    scopus 로고
    • Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress
    • Lapolla A., Reitano R., Seraglia R., Sartore G., Ragazzi E., Traldi P. Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress. Mol. Nutr. Food Res. 2005, 49:685-690.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 685-690
    • Lapolla, A.1    Reitano, R.2    Seraglia, R.3    Sartore, G.4    Ragazzi, E.5    Traldi, P.6
  • 47
    • 77952092094 scopus 로고    scopus 로고
    • Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    • Brouwers O., Niessen P.M., Haenen G., Miyata T., Brownlee M., Stehouwer C.D., De Mey J.G., Schalkwijk C.G. Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Diabetologia 2010, 53:989-1000.
    • (2010) Diabetologia , vol.53 , pp. 989-1000
    • Brouwers, O.1    Niessen, P.M.2    Haenen, G.3    Miyata, T.4    Brownlee, M.5    Stehouwer, C.D.6    De Mey, J.G.7    Schalkwijk, C.G.8
  • 48
    • 0032510747 scopus 로고    scopus 로고
    • Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells
    • Chaplen F.W., Fahl W.E., Cameron D.C. Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:5533-5538.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 5533-5538
    • Chaplen, F.W.1    Fahl, W.E.2    Cameron, D.C.3
  • 49
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • Ghosh S., May M.J., Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 1998, 16:225-260.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 50
    • 0026590541 scopus 로고
    • Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
    • Schreck R., Meier B., Mannel D.N., Droge W., Baeuerle P.A. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 1992, 175:1181-1194.
    • (1992) J. Exp. Med. , vol.175 , pp. 1181-1194
    • Schreck, R.1    Meier, B.2    Mannel, D.N.3    Droge, W.4    Baeuerle, P.A.5
  • 51
    • 0028072422 scopus 로고
    • Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes
    • Bessho R., Matsubara K., Kubota M., Kuwakado K., Hirota H., Wakazono Y., Lin Y.W., Okuda A., Kawai M., Nishikomori R., et al. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem. Pharmacol. 1994, 48:1883-1889.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1883-1889
    • Bessho, R.1    Matsubara, K.2    Kubota, M.3    Kuwakado, K.4    Hirota, H.5    Wakazono, Y.6    Lin, Y.W.7    Okuda, A.8    Kawai, M.9    Nishikomori, R.10
  • 52
    • 0032908620 scopus 로고    scopus 로고
    • Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation
    • Kim C.H, Kim J.H., Hsu C.Y., Ahn Y.S. Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation. FEBS Lett. 1999, 449:28-32.
    • (1999) FEBS Lett. , vol.449 , pp. 28-32
    • Kim, C.H.1    Kim, J.H.2    Hsu, C.Y.3    Ahn, Y.S.4
  • 53
    • 0030861099 scopus 로고    scopus 로고
    • Nitric oxide in the eye: multifaceted roles and diverse outcomes
    • Becquet F., Courtois Y., Goureau O. Nitric oxide in the eye: multifaceted roles and diverse outcomes. Surv. Ophthalmol. 1997, 42:71-82.
    • (1997) Surv. Ophthalmol. , vol.42 , pp. 71-82
    • Becquet, F.1    Courtois, Y.2    Goureau, O.3
  • 54
    • 0036182106 scopus 로고    scopus 로고
    • Involvement of inducible nitric oxide synthase in cataract formation in Shumiya cataract rat (SCR)
    • Inomata M., Hayashi M., Shumiya S., Kawashima S., Ito Y. Involvement of inducible nitric oxide synthase in cataract formation in Shumiya cataract rat (SCR). Curr. Eye Res. 2001, 23:307-311.
    • (2001) Curr. Eye Res. , vol.23 , pp. 307-311
    • Inomata, M.1    Hayashi, M.2    Shumiya, S.3    Kawashima, S.4    Ito, Y.5
  • 56
    • 0035045226 scopus 로고    scopus 로고
    • Review: effects of nitric oxide on eye diseases and their treatment
    • Chiou G.C. Review: effects of nitric oxide on eye diseases and their treatment. J. Ocul. Pharmacol. Ther. 2001, 17:189-198.
    • (2001) J. Ocul. Pharmacol. Ther. , vol.17 , pp. 189-198
    • Chiou, G.C.1
  • 58
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
    • Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:1620-1624.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 59
    • 0029039754 scopus 로고
    • Peroxynitrite-mediated oxidative protein modifications
    • Ischiropoulos H., Al-Mehdi A.B. Peroxynitrite-mediated oxidative protein modifications. FEBS Lett. 1995, 364:279-282.
    • (1995) FEBS Lett. , vol.364 , pp. 279-282
    • Ischiropoulos, H.1    Al-Mehdi, A.B.2
  • 60
    • 0141671740 scopus 로고    scopus 로고
    • Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes
    • Li J., Su J., Li W., Liu W., Altura B.T., Altura B.M. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neurosci. Lett. 2003, 350:173-177.
    • (2003) Neurosci. Lett. , vol.350 , pp. 173-177
    • Li, J.1    Su, J.2    Li, W.3    Liu, W.4    Altura, B.T.5    Altura, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.