Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process

Free Radical Biology and Medicine

Volumn 31, Issue 4, 2001, Pages 469-478

  Du, Jun ^a,b   Suzuki, Haruhiko ^a   Nagase, Fumihiko ^b   Akhand, Anwarul A ^a   Ma, Xiu Yang ^a,b   Yokoyama, Toshihiro ^c   Miyata, Toshio ^d   Nakashima, Izumi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

^d TOKAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; ASK1; Free radicals; Methylglyoxal; Reactive oxygen species; Signal transduction; Superoxide

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; APOPTOSIS SIGNAL REGULATED KINASE 1; BENZOIC ACID DERIVATIVE; DIETHYLDITHIOCARBAMIC ACID; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; METHYLGLYOXAL; MITOGEN ACTIVATED PROTEIN KINASE; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 2; APOPTOSIS; CATALASE; CELL CYCLE; CHELATING AGENTS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DITIOCARB; ENZYME ACTIVATION; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GLUTATHIONE TRANSFERASE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATION-REDUCTION; PLASMIDS; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0035882511     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00611-6     Document Type: Article

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