Induction of G2/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells

Biochemical Pharmacology

Volumn 62, Issue 11, 2001, Pages 1439-1447

  Piao, Wenhua ^a   Yoo, Jeman ^b   Keun Lee, Dug ^b   Jin Hwang, Hyun ^a   Hee Kim, Jeong ^a  

^a Kyung Hee University   (South Korea)

^b DongWha Pharm Ind Co   (South Korea)

Author keywords

Apoptosis; Caspase 3; Cdc 2; DW2282; G2 M phase arrest; HL 60 cells

Indexed keywords

4 PHENYL 1 [N (4 AMINOBENZOYL) INDOLINE 5 SULFONYL 4,5 DIHYDRO 2 IMIDAZLONE]; ANTINEOPLASTIC AGENT; CASPASE 3; CELL CYCLE PROTEIN; DNA FRAGMENT; DW 2282; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL SHAPE; CELL STRAIN HL 60; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIPLOIDY; DNA CONTENT; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DEGRADATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CDC2 PROTEIN KINASE; CELL DIVISION; DOWN-REGULATION; ENZYME ACTIVATION; G2 PHASE; HL-60 CELLS; HUMANS; IMIDAZOLES; LEUKEMIA, PROMYELOCYTIC, ACUTE; MITOSIS; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFONES;

EID: 0035584148     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00796-1     Document Type: Article

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