Intranasal delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin-resistant C57BLK/6-m db/db mice

Diabetes, Obesity and Metabolism

Volumn 12, Issue 10, 2010, Pages 871-875

  Waldrop, M A ^a   Leinung, M C ^a   Lee, D W ^a   Grasso, P ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Bone turnover; Energy balance; Insulin sensitivity; Intranasal delivery; Leptin related peptides; Osteocalcin

Indexed keywords

GLUCOSE; INSULIN; INTRAVAIL; LEPTIN; OSTEOCALCIN; PENETRATION ENHANCING AGENT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; [DEXTRO LEUCINE 4] OB3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG UPTAKE; ENERGY BALANCE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HORMONE ACTION; HORMONE RESISTANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; MALE; MOUSE; NONHUMAN; OSSIFICATION; PROTEIN BLOOD LEVEL; WEIGHT REDUCTION;

EID: 77956156957     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2010.01243.x     Document Type: Article

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