Oral delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice: A study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration

Regulatory Peptides

Volumn 160, Issue 1-3, 2010, Pages 129-132

  Lee, Daniel W ^a   Leinung, Matthew C ^a   Grasso, Patricia ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Leptin; Obesity; Oral delivery; Peptides; Pharmacokinetics

Indexed keywords

OB3 PEPTIDE[4 DEXTRO LEUCINE]; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG UPTAKE; GASTROINTESTINAL ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PLASMA CLEARANCE; PLASMA HALF LIFE; PRIORITY JOURNAL; SWISS WEBSTER MOUSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; LEPTIN; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED STRAINS; PEPTIDE FRAGMENTS;

MUS;

EID: 74749108546     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.12.008     Document Type: Article

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