Type 2 deiodinase and brown fat: The heat is on - Or off

Endocrinology

Volumn 151, Issue 9, 2010, Pages 4087-4089

  Fliers, Eric ^a   Boelen, Anita ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; THYROID HORMONE;

ACCLIMATIZATION; ADIPOGENESIS; ANIMAL; ANIMAL EMBRYO; BLOOD; BROWN ADIPOSE TISSUE; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE; THERMOGENESIS;

ACCLIMATIZATION; ADIPOGENESIS; ADIPOSE TISSUE, BROWN; ANIMALS; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IODIDE PEROXIDASE; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TEMPERATURE; THERMOGENESIS; THYROID HORMONES;

EID: 77956045452     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0712     Document Type: Short Survey

References (31)

1. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR 2009 Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509-1517
2. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ 2009 Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500-1508
3. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P 2009 Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518-1525
4. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP 1997 Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94 (Pubitemid 27202655)
5. Enerbäck S 2010 Human brown adipose tissue. Cell Metab 11:248-252
6. Silva JE 2006 Thermogenic mechanisms and their hormonal regulation. Physiol Rev 86:435-464
7. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC 2010 Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinlogy 151:4573-4582
8. Leonard JL, Mellen SA, Larsen PR 1983 Thyroxine 5′-deiodinase activity in brown adipose tissue. Endocrinology 112:1153-1155
9. Silva JE, Larsen PR 1983 Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305:712-713
10. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC 2001 The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 108:1379-1385
11. 4. Mol Endocrinol 15:2137-2148
12. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng Sy, Bianco AC, Brent GA 2010 Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-β isoform specific and required for adaptive thermogenesis. Endocrinology 151:432-440
13. Sjögren M, Alkemade A, Mittag J, Nordström K, Katz A, Rozell B, Westerblad H, Arner A, Vennström B 2007 Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1. EMBO J 26:4535-4545
14. Cavallo-Perin P, Bruno A, Boine L, Cassader M, Lenti G, Pagano G 1988 Insulin resistance in Graves' disease: a quantitative in vivo evaluation. Eur J Clin Invest 18:607-613
15. Dimitriadis GD, Raptis SA 2001 Thyroid hormone excess and glucose intolerance. Exp Clin Endocrinol Diabetes 109:S225-S239
16. Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E 2008 Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol Endocrinol Metab 294:E513-E520 (Pubitemid 351355221)
17. Vujovic M, Nordström K, Gauthier K, Flamant F, Visser TJ, Vennström B, Mittag J 2009 Interference of a mutant thyroid hormone receptor α1 with hepatic glucose metabolism. Endocrinology 150:2940-2947
18. Nguyen TT, Chapa F, DiStefano 3rd JJ 1998 Direct measurement of the contributions of type I and type II 5′-deiodinases to whole body steady state 3,5,3′-triiodothyronine production from thyroxine in the rat. Endocrinology 139:4626-4633
19. Silva JE, Bianco SDC 2008 Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid 18:157-165
20. Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ 1998 Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol Regul Integr Comp Physiol 275(1 Pt 2):R291-R299
21. Bamshad M, Song CK, Bartness TJ 1999 CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276(6 Pt 2):R1569-R1578 (Pubitemid 29323518)
22. la Fleur SE, Kalsbeek A, Wortel J, Buijs RM 2000 Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res 871:50-56
23. Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A, Van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs RM 2002 Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications. J Clin Invest 110:1243-1250
24. Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, Boelen A, Ackermans MT, Sauerwein HP, Fliers E, Kalsbeek A 2009 Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc Natl Acad Sci USA 106:5966-5971
25. Fliers E, Klieverik LP, Kalsbeek A 2010 Novel neural pathways for metabolic effects of thyroid hormone. Trends Endocrinol Metab 21:230-236
26. Frontini A, Cinti S 2010 Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11:253-256
27. Skarulis MC, Celi FS, Mueller E, Zemskova M, Malek R, Hugendubler L, Cochran C, Solomon J, Chen C, Gorden P 2010 Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. J Clin Endocrinol Metab 95:256-262
28. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J 2006 Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439: 484-489
29. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J 2009 UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9:203-209
30. Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St. Germain DL, Forrest D 2009 A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology 150:1952-1960
31. Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St. Germain DL, Hernandez A, Pugh Jr EN, Forrest D 2010 Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci 30: 3347-3357