Direct measurement of the contributions of type I and type II 5'- deiodinases to whole body steady state 3,5,3'-triiodothyronine production from thyroxine in the rat

Endocrinology

Volumn 139, Issue 11, 1998, Pages 4626-4633

  Nguyen, Thuvan T ^a   Chapa, Francisco ^a   Distefano III, Joseph J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 125; IODINE 131; LIOTHYRONINE; PLACEBO; PROPYLTHIOURACIL; THYROXINE; THYROXINE DEIODINASE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; THYROID HORMONE RELEASE; THYROID HORMONE SYNTHESIS; THYROIDECTOMY;

EID: 0031736678     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.11.6323     Document Type: Article

References (31)

1. St Germain DL 1994 Iodothyronine deiodinases. Trends Endocrinol Metab 5:36-42
2. Sharifi J, St Germain DL 1992 The cDNA for type 1 iodothyronine 5′-deiodinase encodes an enzyme manifesting both high Km and low Km activity J Biol Chem 267:12539-12544
3. St Germain DL, Galton, VA 1997 The deiodinase family of selenoproteins. Thyroid 7:655-668
4. Tu HM, Kim S-W, Salvatore D, Bartha T, Legradi G, Larsen PR, Lechan RM 1997 Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 138:3359-3368
5. Visser TJ, Kaplan MM, Leonard JL, Larsen PR 1983 Evidence for two pathways of iodothvronine 5′-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest 71:992-1002
6. Silva JE, Larsen PR 1985 Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest 76:2296-2305
7. Campos-Barros A, Hoell T, Musa A, Sampaolo S, Stoltenburg G, Pinna G, Eravci M, Meinhold H, Baumgartner A 1996 Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system. J Clin Endocrinol Metab 81:2179-2185
8. Salvatore D, Tibor B, Harney JW, Larsen PR 1996 Molecular biology and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 137:3308-3315
9. Salvatore D, Tu H, Harney JW, Larsen PR 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 98:962-968
10. Croteau W, Davey JC, Galton VA, St Germain DL 1996 Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in the human brain and other tissues. J Clin Invest 98:405-417
11. Kaplan MM 1986 Regulatory influences on iodothyronine deiodination in animal tissues. In: Hennemann G (eds) Thyroid Hormone Metabolism. Marcel Dekker, New York, pp 231-253
12. Meinhold H, Campos-Barros A, Walzog B, Kohler R, Muller F, Behne D 1993 Effects of selenium and iodine deficiency on type I, type II and type III iodothyronine deiodinases and circulating thyroid hormones in the rat. Exp Clin Endocrinol 101:87-93
13. Leonard JL, Kaplan MM, Visser TJ, Silva JE, Larsen PR 1981 Cerebral cortex reponds rapidly to thyroid hormones. Science 214:571-573
14. Escobar-Morreale HF, Obregon MJ, Hernadez A, Escobar del Rey F, Morreale de Escobar 1997 Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine. Endocrinology 138:2559-2568
15. Oppenheimer JH, Schartz HL, Surks MI 1972 Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone. J Clin Invest 51:2493-2497
16. 3) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. Metabolism 24:547-554
17. Larsen PR, Frumess RD 1977 Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology 100:980-988
18. 3 production in the rat. Endocrinology 137:2580-2585
19. Van Doom J, Roelfsema F, van der Heide D 1983 The effect of propylthiouracil and methimazole on the peripheral conversion of thyroxine to 3,5,3′-triiodothyronine in athyreotic thyroxine-maintained rats. Acta Endocrinol (Copenh) 103:509-520
20. 3 pools in fed and fasted rats: hormone regulation implications. Endocrinology 134:1700-1709
21. 3 ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology 137:2490
22. 3) in intestines, liver, kidneys, blood and residual carcass of the rat in vivo. Endocrinology 133:2973-2983
23. 3-hyperthyroid rats. Endocrinology 137:5624-5633
24. Williams AD, Freeman DE, Florsheim WH 1969 Sephadex LH-20 column separation of thyroidal iodoamino acids. J Chromatogr 45:371-380
25. Goswami A, Rosenberg IN 1986 Iodothyronine 5′-deiodinase in brown adipose tissue: thiol activation and propylthiouracil inhibition. Endocrinology 119:916-923
26. Escobar FDR, Morreale de Escobar G 1961 The effect of propylthiouracil, methylthiouracil and thiouracil on the peripheral metabolism of L-thyroxine in thyroidectomized, L-thyroxine maintained rats. Endocrinology 69:456-465
27. Saberi M, Sterling FH, Utiger RD 1975 Reduction in extrathyroidal triiodothyronine production by propylthiouracil in man. J Clin Invest 55:218-223
28. 35S]propylthiouracil by the rat thyroid. Endocrinology 96:1324-1328
29. DiStefano III JJ 1989 Hormone kinetic analysis. In: DeGroot LJ (ed) Endocrinology, ed 2, chapt 160. Grune and Stratton, , pp 2726-2740
30. Rutgers M, Bonthuis F, de Herder WW, Visser TJ 1987 Accumulation of plasma triiodothyronine sulfate in rats treated with propylthiouracil. J Clin Invest 80:758-762
31. Visser TJ 1994 Role of sulfation in thyroid hormone metabolism. Chem Biol Interact 92:293-303