The influence of vitamin E on immune function and response to vaccination in older horses

Journal of Animal Science

Volumn 88, Issue 9, 2010, Pages 2950-2958

  Petersson, K H ^a   Burr, D B ^a,c   Gomez Chiarri, M ^a   Petersson Wolfe, C S ^b  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Aging; Horse; Immune response; Lysozyme activity; Vaccination; Vitamin E

Indexed keywords

IMMUNOGLOBULIN G; TOCOPHEROL; VIRUS ANTIBODY; VIRUS VACCINE;

AGING; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HORSE; HORSE DISEASE; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; WEST NILE FEVER;

ADMINISTRATION, ORAL; AGING; ANIMALS; ANTIBODIES, VIRAL; HORSE DISEASES; HORSES; IMMUNOGLOBULIN G; TOCOPHEROLS; VIRAL VACCINES; WEST NILE FEVER;

BACTERIA (MICROORGANISMS); EQUIDAE; WEST NILE VIRUS;

EID: 77956004539     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2008-1724     Document Type: Article

References (47)

1. Austin, S. M., J. H. Foreman, and L. L. Hungerford. 1995. Case-control study of risk factors for development of pleuropneumonia in horses. J. Am. Vet. Med. Assoc. 207:325-328.
2. Aw, D., A. B. Silva, and D. B. Palmer. 2007. Immunosenescence: Emerging challenges for an ageing population. Immunology 120:435-446.
3. Baalsrud, K. J., and G. Overnes. 1986. Influence of vitamin E and selenium supplement on antibody production in horses. Equine Vet. J. 18:472-474.
4. Babinszky, L., D. J. Langhout, M. W. Verstegen, L. A. den Hartog, P. Joling, and M. Nieuwland. 1991. Effect of vitamin E and fat source in sows' diets on immune response of suckling and weaned piglets. J. Anim. Sci. 69:1833-1842.
5. Butcher, S. K., H. Chahal, L. Nayak, A. Sinclair, N. V. Henriquez, E. Sapey, D. O'Mahony, and J. M. Lord. 2001. Senescence in innate immune responses: Reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J. Leukoc. Biol. 70:881-886.
6. Carroll, C. L., and P. J. Huntington. 1988. Body condition scoring and weight estimation of horses. Equine Vet. J. 20:41-45.
7. Craig, A. M., L. L. Blythe, K. E. Rowe, E. D. Lassen, R. Barrington, and K. C. Walker. 1992. Variability of alpha-tocopherol values associated with procurement, storage, and freezing of equine serum and plasma samples. Am. J. Vet. Res. 53:2228-2234.
8. Davidson, A. H., J. L. Traub-Dargatz, R. M. Rodeheaver, E. N. Ostlund, D. D. Pedersen, R. G. Moorhead, J. B. Stricklin, R. D. Dewell, S. D. Roach, R. E. Long, S. J. Albers, R. J. Callan, and M. D. Salman. 2005. Immunologic responses to West Nile virus in vaccinated and clinically affected horses. J. Am. Vet. Med. Assoc. 226:240-245.
9. Eicher, S. D., J. L. Morrill, F. Blecha, C. G. Chitko-McKown, N. V. Anderson, and J. J. Higgins. 1994. Leukocyte functions of young dairy calves fed milk replacers supplemented with vitamins A and E. J. Dairy Sci. 77:1399-1407.
10. Fermaglich, D. H., and D. W. Horohov. 2002. The effect of aging on immune responses. Vet. Clin. North Am. Equine Pract. 18:621-630.
11. Firth, M. A., P. E. Shewen, and D. C. Hodgins. 2005. Passive and active components of neonatal innate immune defenses. Anim. Health Res. Rev. 6:143-158.
12. Franceschi, C., M. Bonafe, and S. Valensin. 2000. Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18:1717-1720.
13. Gay, R. T., S. Belisle, M. A. Beck, and S. N. Meydani. 2006. An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain. Proc. Natl. Acad. Sci. USA 103:13825-13830.
14. Gebremichael, A., E. M. Levy, and L. M. Corwin. 1984. Adherent cell requirement for the effect of vitamin E on in vitro antibody synthesis. J. Nutr. 114:1297-1305.
15. Goto, H., Y. Yamamoto, C. Ohta, T. Shirahata, T. Higuchi, and H. Ohishi. 1993. Antibody responses of Japanese horses to influenza viruses in the past few years. J. Vet. Med. Sci. 55:33-37.
16. Hall, L. W. 1971. Wrights Veterinary Anaesthesia and Analgesia. 7th ed. Bailliere Tindall, London, UK.
17. Hayek, M. G., S. F. Taylor, B. S. Bender, S. N. Han, M. Meydani, D. E. Smith, S. Eghtesada, and S. N. Meydani. 1997. Vitamin E supplementation decreases lung virus titers in mice infected with influenza. J. Infect. Dis. 176:273-276.
18. Hidiroglou, M., T. R. Batra, L. F. Laflamme, and F. Markham. 1992. Possible roles of vitamin E in immune response of calves. Int. J. Vitam. Nutr. Res. 62:308-311.
19. Higgins, J. K., B. Puschner, P. H. Kass, and N. Pusterla. 2008. Assessment of vitamin E concentrations in serum and cerebrospinal fluid of horses following oral administration of vitamin E. Am. J. Vet. Res. 69:785-790.
20. Hogan, J. S., K. L. Smith, W. P. Weiss, D. A. Todhunter, and W. L. Schockey. 1990. Relationships among vitamin E, selenium, and bovine blood neutrophils. J. Dairy Sci. 73:2372-2378.
21. Hogan, J. S., W. P. Weiss, and K. L. Smith. 1993a. Role of vitamin E and selenium in host defense against mastitis. J. Dairy Sci. 76:2795-2803.
22. Hogan, J. S., W. P. Weiss, K. L. Smith, D. A. Todhunter, P. S. Schoenberger, and S. N. Williams. 1993b. Vitamin E as an adjuvant in an Escherichia coli J5 vaccine. J. Dairy Sci. 76:401-407.
23. Horohov, D. W., A. Dimock, P. Guirnalda, R. W. Folsom, K. H. McKeever, and K. Malinowski. 1999. Effect of exercise on the immune response of young and old horses. Am. J. Vet. Res. 60:643-647.
24. Horohov, D. W., J. H. Kydd, and D. Hannant. 2002. The effect of aging on T cell responses in the horse. Dev. Comp. Immunol. 26:121-128.
25. Jakubowski, K., M. Jedlinska-Krakowska, and A. K. Siwicki. 2004. The level of some acute phase proteins, total protein, gammaglobulins and activity of lysozyme in blood plasma of rats supplemented with vitamin E and exposed to ozone. Pol. J. Vet. Sci. 7:283-287.
26. Kandil, O. M., and H. A. Abou-Zeina. 2005. Effect of parenteral vitamin E and selenium supplementation on immune status of dogs vaccinated with subunit and somatic antigens against Taenia hydatigena. J. Egypt. Soc. Parasitol. 35:537-550.
27. Lesourd, B. M., L. Mazari, and M. Ferry. 1998. The role of nutrition in immunity in the aged. Nutr. Rev. 56:S113-S125.
28. Lord, J. M., S. Butcher, V. Killampali, D. Lascelles, and M. Salmon. 2001. Neutrophil ageing and immunesenescence. Mech. Ageing Dev. 122:1521-1535.
29. Lunn, D. P., M. A. Holmes, B. Schram, and W. P. Duffus. 1995. Monoclonal antibodies specific for equine IgG sub-isotypes including an antibody which recognizes B lymphocytes. Vet. Immunol. Immunopathol. 47:239-251.
30. Malinowski, K., R. A. Christensen, A. Konopka, C. G. Scanes, and H. D. Hafs. 1997. Feed intake, body weight, body condition score, musculation, and immunocompetence in aged mares given equine somatotropin. J. Anim. Sci. 75:755-760.
31. Malinowski, K., E. J. Shock, P. Rochelle, C. F. Kearns, P. D. Guirnalda, and K. H. McKeever. 2006. Plasma β-endorphin, cortisol and immune responses to acute exercise are altered by age and exercise training in horses. Equine Vet. J. Suppl. 36:267-273.
32. Meydani, S. N., and A. A. Beharka. 1996. Recent developments in vitamin E and immune response. Nutr. Rev. 56:S49-S58.
33. Meydani, S. N., M. Meydani, J. B. Blumberg, L. S. Leka, G. Siber, R. Loszewski, C. Thompson, M. C. Pedrosa, R. D. Diamond, and B. D. Stollar. 1997. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. J. Am. Med. Assoc. 277:1380-1386.
34. Minke, J. M., L. Siger, K. Karaca, L. Austgen, P. Gordy, R. Bowen, R. W. Renshaw, S. Loosmore, J. C. Audonnet, and B. Nordgren. 2004. Recombinant canarypoxvirus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challenge. Arch. Virol. Suppl. 18:221-230.
35. Moriguchi, S., and M. Muraga. 2000. Vitamin E and immunity. Vitam. Horm. 59:305-336.
36. Muirhead, T. L., J. T. McClure, J. J. Wichtel, H. Stryhn, R. J. Frederick Markham, D. McFarlane, and D. P. Lunn. 2008. The effect of age on serum antibody titers after rabies and influenza vaccination in healthy horses. J. Vet. Intern. Med. 22:654-661.
37. NRC. 2007. Nutrient Requirements of Horses. 6th rev. ed. Natl. Acad. Press, Washington, DC.
38. Petersson, K. H., H. F. Hintz, H. F. Schryver, and G. F. Combs Jr 1991. The effect of vitamin E on membrane integrity during submaximal exercise. Pages 315-322 in Equine Exercise Physiology 3. Proc. 3rd Int. Conf. Equine Exerc. Physiol. S. G. B. Persson, A. Lindholm, and L. Jefcott, ed. Int. Conf. Equine Exerc. Physiol. Publication, Davis, CA.
39. Ralston, S. L., C. F. Nockels, and E. L. Squires. 1988. Differences in diagnostic test results and hematologic data between aged and young horses. Am. J. Vet. Res. 49:1387-1392.
40. Rivera, J. D., G. C. Duff, M. L. Galyean, D. A. Walker, and G. A. Nunnery. 2002. Effects of supplemental vitamin E on performance, health, and humoral immune response of beef cattle. J. Anim. Sci. 80:933-941.
41. Ronéus, B. O., R. V. Hakkarainen, C. A. Lindholm, and J. T. Työppönen. 1986. Vitamin E requirements of adult Standardbred horses evaluated by tissue depletion and repletion. Equine Vet. J. 18:50-58.
42. Rosendal, S., J. H. Lumsden, L. Viel, and P. W. Physick-Sheard. 1987. Phagocytic function of equine neutrophils exposed to Mycoplasma felis in vitro and in vivo. Am. J. Vet. Res. 48:758-762.
43. Serafini, M. 2000. Dietary vitamin E and T cell-mediated function in the elderly: Effectiveness and mechanism of action. Int. J. Dev. Neurosci. 18:401-410.
44. Siciliano, P. D. 2002. Nutrition and feeding of the geriatric horse. Vet. Clin. North Am. Equine Pract. 18:491-508.
45. Stellflug, J. N. 2006. Comparison of cortisol, luteinizing hormone, and testosterone responses to a defined stressor in sexually inactive rams and sexually active female-oriented and maleoriented rams. J. Anim. Sci. 84:1520-1525.
46. Tizzard, I. R. 2004. Veterinary Immunology: An Introduction. 7th ed. Saunders, Philadelphia, PA.
47. Williams, C. A., M. E. Gordon, C. L. Betros, and K. H. McKeever. 2008. Apoptosis and antioxidant status are influenced by age and exercise training in horses. J. Anim. Sci. 86:576-583.