Placental transfer and pharmacokinetics of a single dermal dose of [14C]methyl parathion in rats

Toxicological Sciences

Volumn 53, Issue 1, 2000, Pages 5-12

  Abu Qare, Aqel W ^a   Abdel Rahman, Ali A ^a   Kishk, Amal M ^a   Abou Donia, Mohamed B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetylcholinesterase inhibition organophosphorus insecticide; Cytochrome P450; Metabolic activation; Methyl parathion

Indexed keywords

4 NITROPHENOL; ACETYLCHOLINESTERASE; CARBON 14; CYTOCHROME P450; PARATHION METHYL;

ABSORPTION; ANIMAL TISSUE; ARTICLE; DERMIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NONHUMAN; PHARMACOKINETICS; PLACENTAL TRANSFER; RADIOACTIVITY; RAT; TISSUE DISTRIBUTION;

EID: 0033971362     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.1.5     Document Type: Article

References (53)

1. 14C]chlorpyrifos in Sprague-Dawley rats. Toxicologist 13, 176.
2. Abou-Donia, M. B. (1979). Pharmacokinetics and metabolism of a topically applied dose of 0-4-bromo-2-5-dichlorophenyl 0-methyl phenylphosphonothioate in hens. Toxicol. Appl. Pharmacol. 51, 311-328.
3. Abou-Donia, M. B. (1994). Organophosphorus Pesticides. In: Handbook of Neurotoxicology, (L. W. Chang and R. S. Dyer, Eds.), pp. 419-473. Marcel Dekker, New York.
4. Abou-Donia, M. B. (1995). Metabolism and toxicokinetics of xenobiotics. In Handbook of Toxicology (M. J., Derealnko and M. A., Hollinger, Eds.), pp. 539-589. CRC Press, Boca Raton.
5. Abou-Donia, M. B., Kinnes, C. G., Abdo, K. M., and Bjornson, T. D. (1983). Physiological disposition and metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate in male cats, following a single dermal administration. Drug. Metab. Dispos. 11, 31-36.
6. Aldridge, W. N. (1953). Serum esterases: An enzyme hydrolizing diethyl p-nitrophenyl phosphate (E600) and its identity with the A-esterase of mammalian sera. Biochem. J. 53, 117-124.
7. ATSDR ( )1997). Methyl parathion health threat. Hazardous Substances and Public Health 7, 4-5.
8. Baynes, R. E., and Bowen, J. M. (1995). Toxicokinetics of methyl parathion in lactating goats. J. Agri. Food Chem. 43, 1598-1604.
9. Benke, G. M., and Murphy, S. D. (1975). The influence of age on the toxicity and metabolism of methyl parathion in male and female rats. Toxicol. Appl. Pharmacol. 31, 254-269.
10. Brackman, R. A., Audenaent, F., Willems, J. L., Belpaire, F. M., and Bogaert, M. G. (1983). Toxicokinetics of methyl parathion and parathion in the dog after intravenous and oral administration. Arch. Toxicol. 54, 71-82.
11. Butler, A. M., and Murray, M. (1997). Biotransformation of parathion in human liver: Participation of CYP3A4 and its interaction during microsomal parathion oxidation. J. Pharmacol. Exper. Therap. 280, 966-973.
12. Carver, M. P., and Riviere, J. E. (1989). Percutaneous absorption and excretion of xenobiotics after topical and intravenous administration to pigs. Fundam. Appl. Toxicol. 13, 714-722.
13. Chambers, J. E., Chambers, H. W., and Snawder, J. E. (1991). Target site and activation of the neurotoxic organophosphorous insecticide parathion in partially hepatectomized rats. Life Sci. 48, 1023-1029.
14. Chang, S. K., and Riviere, J. E. (1991). Percutaneous absorption of parathion in vitro in porcine skin: Effects of dose, temperature, humidity, and perfusate composition on absorptive flux. Fundam. Appl. Toxicol. 17, 494-504.
15. Combes, B., and Stakelum, G. S. (1962). Maturation of the sulfobromophthalein sodium-glutathione conjugating system in rat liver. J. Clin. Invest. 41, 750-757.
16. de Lima, J. S., Bastos Neto, J. da D., da Cunha, J. C., Moraes, F. F. M., Ferreira, M. de F., Moreira, J. C., and Faria, M. V. C. (1996). Methyl parathion activation by a partially purified rat brain fraction. Toxicol. Lett. 87, 53-60.
17. De Schryver, E., Dereu, L., Belpaire, F., and Willems, J. (1987). Toxicokinetics of methyl paraoxon in the dog. Arch. Toxicol. 59, 319-322.
18. Draper, W. M., and Street, J. C. (1981). Drift from a commercial aerial application of methyl parathion and ethyl parathion: An estimation of potential human exposure. Bull. Environ. Contam. Toxicol. 26, 530-536.
19. Eigenberg, D. A., Pazdernik, T. L., and Doull, J. (1983). Hemoperfusion and pharmacokinetic studies with parathion and paraoxon in the rat and dog. Drug Metab. Dispos. 11, 366-370.
20. Feuer, G. (1979). Action of pregnancy and various progesterones on hepatic microsomal activities. Drug Metab. Rev. 9, 147-169.
21. Garcia-Repetto, Martinez, D., and Repetto, M. (1997). Biodisposition study of the organophosphorus pesticide, methyl-paration. Bull. Environ. Contain. Toxicol., 59, 901-908.
22. Hollingworth, R. M., Alston, R. L., and Litzenberg, R. D. (1973). Glutathion-S-aryl transferase in the metabolism of parathion and its analogs. Life Sci. 13, 191-199.
23. Hollingworth, R. M., Metcalf, R. L., and Fukuto, T. R. (1967). The selectivity of Sumithion compared with methyl parathion: Metabolism in the white mouse. J. Agri. Food Chem. 15, 242-249.
24. Howard, J. K., East, N. J., and Chaney, J. L. (1978). Plasma cholinesterase activity in early pregnancy. Arch. Environ., Health 277-279.
25. Huang, Y.S., and Sultatos, L.G. (1993). Glutathione-dependent biotransformation of methyl parathion by mouse liver in vitro. Toxicol. Lett. 68, 275-284.
26. Knaak, J. B., Yee, K., Ackerman, C. R., Zweig, G., Fry, D. M., and Wilson, B. W. (1984). Percutaneous absorption and dermal dose-cholinesterase response studies with parathion and carbaryl in the rat. Toxicol. Appl. Pharmacol. 76, 252-263.
27. Milne, M. D., Schribner, B. N., and Craford, M. A. (1958). Non-toxic diffusion and excretion of weak acids and bases. Amer. S. Med. 24, 709-729.
28. Neal, R. A. (1967). Studies on the metabolism of deithyl 4-nitrophenyl phosphorothionate (parathion) in vitro. Biochem. J. 103, 183-191.
29. Neale, M. G., and Parke, D. V. (1973). Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochem. Pharmacol. 22, 1451-1461.
30. Nielsen, P., Friis, C., Gyrd-Hansen, N., and Kraul, I. (1991). Disposition of parathion in neonatal and young pigs. Pharmacol. Toxicol. 68, 233-237.
31. Nolan, R. J., Rick, D. L., Freshour, N. L., and Saunders, J. H. (1984). Chrorpyrifos: Pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 73, 8-15.
32. Norman, B. J., and Neal, R. A. (1976). Examination of the metabolism in vitro of parathion (diethyl p-nitrophenyl phosphorothionate) by rat lung and brain. Biochem. Pharmacol. 25, 37-45.
33. Norman, B. J., Roth, J. A., and Neal, R. A. (1973). Effect of temperature on the mixed function oxidase-catalyzed metabolism of O,O-diethyl p-nitrophenyl phosphorothionate (parathion). Toxicol. Appl. Pharmacol. 26, 203-208.
34. Pulkkinen, M. O. (1966). Sulfate conjugation during pregnancy and under the influence of cortisone. Acta Physiol. Scand. 66, 120-123.
35. Qiao, G. L., Williams, P. L., and Riviere, J. E. (1994). Percutaneous absorption, biotransformation, and systemic disposition of parathion in vivo in swine: I. Comprehensive pharmacokinetics model. Drug Metab. and Dispos. 22, 459-471.
36. Radulovic, L. L., and Kulkarni, A. P. (1987). Biotransformation of methyl parathion by human fetal liver glutathione-S-transferases: An in vitro study. Xenobiotica 17, 105-114.
37. 14C-acetyl]acephate in Sprague-Dawley rats. J. Occup. Med. Toxicol. 1, 265-274.
38. 3S] methamidophos in Sprague-Dawley rats. J. Occup. Med. Toxicol. 1, 275-291.
39. Sartorelli, P., Aprea, C., Bussani, R., Novelli, M. T., Oris, D., and Sciarra, G. (1997). In vitro precutaneous penetration of methyl parathion from a commercial formulation through the human skin. J. Occup. Environ. Med. 54, 424-525.
40. Scheuplein, R. J. and Blank, I. H. (1971). Permeability of the skin. Physiol. Rev. 51, 702-747.
41. Shnider, S. M. (1965). Serum cholinesterase activity during pregnancy, labor and the puerperium. Anesthesiology 26, 335-339.
42. Stock, B., Dean, M., and Levy, G. (1980). Serum protein binding of drugs during and after pregnancy in rats. J. Pharmacol. Exp. Ther. 212, 264-268.
43. Sultatos, L. G. (1987). The role of the liver in mediating the acute toxicity of the pesticide methyl parathion in the mouse. Drug Metab. Dispos. 15, 613-617.
44. Sultatos, L.G., Kim, B., and Woods, L. (1990). Evaluation of estimations in vitro of tissue/blood distribution coefficients for organophosphate insecticides. Toxicol. Appl. Pharmacol. 103, 52-55.
45. Sultatos, L. G., and Murphy, S. D. (1983). Kinetic analyses of the microsomal biotransformation of the phosphorothioate insecticides chlorpyrifos and parathion. Fundam. Appl. Toxicol. 3, 16-21.
46. Tyndall, R. L., and Daniel, J. C. (1975). Alterations in uterine and serum esterases in pregnant mammals. Fertil. Steril. 26, 1098-1104.
47. 14C-parathion administered intravenously to sheep. Toxicol. Appl. Pharmacol. 21, 542-548.
48. Weitman, S. D., Vodicnik, M. J., and Lech, J. J. (1983). Influence of pregnancy on parathion toxicity and disposition. Toxicol. Appl. Pharmacol. 71, 215-224.
49. Wester, R. C., Sedik, L., Melendres, J., Logan, F., Haibach, H. I., and Russell, I. (1993). Precutaneous absorption of Diazinon in humans. Food Chem. Toxicol. 31, 469-572.
50. WHO (World Health Organization) (1993). Environmental Health Criteria (Report #164): Methyl parathion. IPCS, Geneva.
51. Wurster, D. E., and Kramer, S. F. (1961). Some factors influencing percutaneous absorption. J. Pharm. Sci. 50, 288-293.
52. Yamamoto, T., Egashira, T., Yoshida, T., and Kuroiwa, Y. (1983). Comparative metabolism of fenitrothion and methyl parathion in male rats. Acta Pharmacol Toxicol. 53, 96-102.
53. Zhang, H. X., and Sultatos, L. G. (1991). Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat liver perfused in situ. Drug Metab. Dispos. 19, 473-477.