메뉴 건너뛰기




Volumn 26, Issue 3, 2010, Pages 241-246

The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's disease

Author keywords

Alzheimer's disease; ApoE; Gab2; Signal transduction

Indexed keywords

CRK LIKE PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2 ASSOCIATED BINDER 2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GAB2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 77955972241     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-010-1109-7     Document Type: Short Survey
Times cited : (21)

References (34)
  • 1
    • 77955599451 scopus 로고    scopus 로고
    • Function, regulation and pathological roles of the Gab/DOS docking proteins
    • Wöhrle FU, Daly RJ, Brummer T. Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal 2009, 7: 22.
    • (2009) Cell Commun Signal , vol.7 , pp. 22
    • Wöhrle, F.U.1    Daly, R.J.2    Brummer, T.3
  • 2
    • 0037333264 scopus 로고    scopus 로고
    • The 'Gab' in signal transduction
    • Gu HH, Neel BG. The 'Gab' in signal transduction. TRENDS Cell Biol 2003, 13(3): 122-130.
    • (2003) TRENDS Cell Biol , vol.13 , Issue.3 , pp. 122-130
    • Gu, H.H.1    Neel, B.G.2
  • 3
    • 0347660479 scopus 로고    scopus 로고
    • The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
    • Nishida K, Hirano T. The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Sci 2003, 94(12): 1029-1033.
    • (2003) Cancer Sci , vol.94 , Issue.12 , pp. 1029-1033
    • Nishida, K.1    Hirano, T.2
  • 4
    • 26844514477 scopus 로고    scopus 로고
    • Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor
    • Meng SS, Chen ZM, Munoz-Antonia T, Wu J. Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. Biochem J 2005, 391(Pt1): 143-151.
    • (2005) Biochem J , vol.391 , Issue.PART1 , pp. 143-151
    • Meng, S.S.1    Chen, Z.M.2    Munoz-Antonia, T.3    Wu, J.4
  • 6
    • 53049091130 scopus 로고    scopus 로고
    • Interleukin-3(IL-3)-induced c-fos activation is modulated by Gab2-Calcineurin interaction
    • Pyarajan S, Matejovic G, C.Pratt G, Baksh S, Burakoff SJ. Interleukin-3(IL-3)-induced c-fos activation is modulated by Gab2-Calcineurin interaction. J Biol Chem. 2008, 283(35): 23505-23509.
    • (2008) J Biol Chem. , vol.283 , Issue.35 , pp. 23505-23509
    • Pyarajan, S.1    Matejovic, G.2    Pratt, G.C.3    Baksh, S.4    Burakoff, S.J.5
  • 7
    • 64649104786 scopus 로고    scopus 로고
    • Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: Role of JAK/STAT, PI3K, PKC and MAP kinases
    • Tripathi A, Sodhi A. Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: Role of JAK/STAT, PI3K, PKC and MAP kinases. Immunobiology 2009, 214(6): 430-440.
    • (2009) Immunobiology , vol.214 , Issue.6 , pp. 430-440
    • Tripathi, A.1    Sodhi, A.2
  • 10
    • 17844399784 scopus 로고    scopus 로고
    • The amyloid precursor protein and its network of interacting proteins: Physiological and pathological implications
    • Russo C, Venezia V, Repetto E, Nizzari M, Violani E, Carlo P, et al. The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications. Brain Res Rev 2005, 48(2): 257-264.
    • (2005) Brain Res Rev , vol.48 , Issue.2 , pp. 257-264
    • Russo, C.1    Venezia, V.2    Repetto, E.3    Nizzari, M.4    Violani, E.5    Carlo, P.6
  • 11
  • 12
  • 13
    • 33644694711 scopus 로고    scopus 로고
    • The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling
    • Sármay G, Angyal A, Kertész A, Maus M, Medgyesi D. The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol Lett 2006, 104(1-2): 76-82.
    • (2006) Immunol Lett , vol.104 , Issue.1-2 , pp. 76-82
    • Sármay, G.1    Angyal, A.2    Kertész, A.3    Maus, M.4    Medgyesi, D.5
  • 14
    • 14044272770 scopus 로고    scopus 로고
    • A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
    • Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P. A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J Biol Chem 2005, 280(7): 5350-5360.
    • (2005) J Biol Chem , vol.280 , Issue.7 , pp. 5350-5360
    • Montagner, A.1    Yart, A.2    Dance, M.3    Perret, B.4    Salles, J.P.5    Raynal, P.6
  • 15
    • 62749184858 scopus 로고    scopus 로고
    • Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells
    • Caron C, Spring K, Laramee M, Chabot C, Cloutier M, Gu HH, et al. Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. Cell Signal 2009, 21(6): 943-953.
    • (2009) Cell Signal , vol.21 , Issue.6 , pp. 943-953
    • Caron, C.1    Spring, K.2    Laramee, M.3    Chabot, C.4    Cloutier, M.5    Gu, H.H.6
  • 17
    • 62449265137 scopus 로고    scopus 로고
    • Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA
    • Huang F, Tong XY, Deng HM, Fu LQ, Zhang RH. Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA. Cell Mol Immunol 2008, 5(6): 433-438.
    • (2008) Cell Mol Immunol , vol.5 , Issue.6 , pp. 433-438
    • Huang, F.1    Tong, X.Y.2    Deng, H.M.3    Fu, L.Q.4    Zhang, R.H.5
  • 18
    • 55549092077 scopus 로고    scopus 로고
    • Gab2 is involved in differential Phosphoinositide 3-Kinase signaling by two splice forms of c-Kit
    • Sun JM, Pedersen M, Ronnstrand L. Gab2 is involved in differential Phosphoinositide 3-Kinase signaling by two splice forms of c-Kit. J Biol Chem 2007, 283(41): 27444-27451.
    • (2007) J Biol Chem , vol.283 , Issue.41 , pp. 27444-27451
    • Sun, J.M.1    Pedersen, M.2    Ronnstrand, L.3
  • 19
    • 0036675635 scopus 로고    scopus 로고
    • The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer
    • Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, et al. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. Oncogene 2002, 21(33): 5175-5181.
    • (2002) Oncogene , vol.21 , Issue.33 , pp. 5175-5181
    • Daly, R.J.1    Gu, H.2    Parmar, J.3    Malaney, S.4    Lyons, R.J.5    Kairouz, R.6
  • 21
    • 51049100827 scopus 로고    scopus 로고
    • Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    • Brummer T, Larance M, Herrera Abreu MT, Lyons M, Timpson P, Emmerich CH, et al. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J 2008, 27(17): 2305-2316.
    • (2008) EMBO J , vol.27 , Issue.17 , pp. 2305-2316
    • Brummer, T.1    Larance, M.2    Herrera Abreu, M.T.3    Lyons, M.4    Timpson, P.5    Ch, E.6
  • 22
    • 53949088425 scopus 로고    scopus 로고
    • Genetic predisposition to inflammation: A new risk factor of Alzheimer's Disease
    • Wan Y, Wang G, Chen SD. Genetic predisposition to inflammation: a new risk factor of Alzheimer's Disease. Neurosci Bull 2008, 24: 314-322.
    • (2008) Neurosci Bull , vol.24 , pp. 314-322
    • Wan, Y.1    Wang, G.2    Chen, S.D.3
  • 23
    • 55749106048 scopus 로고    scopus 로고
    • The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease
    • Hernández F, Avila J. The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease. FEBS Lett 2008, 582: 3848-3854.
    • (2008) FEBS Lett , vol.582 , pp. 3848-3854
    • Hernández, F.1    Avila, J.2
  • 26
    • 0141483389 scopus 로고    scopus 로고
    • GC-GAP, a Rho family GTPase-activating protein that in teracts with signaling adapters Gab1 and Gab2
    • Zhao CM, Ma H, Bossy-Wetzel E, Lipton SA, Zhang ZH, Feng GS. GC-GAP, a Rho family GTPase-activating protein that in teracts with signaling adapters Gab1 and Gab2. J Biol Chem 2003, 278(36): 34641-34653.
    • (2003) J Biol Chem , vol.278 , Issue.36 , pp. 34641-34653
    • Zhao, C.M.1    Ma, H.2    Bossy-Wetzel, E.3    Lipton, S.A.4    Zh, Z.5    Feng, G.S.6
  • 27
    • 64049116471 scopus 로고    scopus 로고
    • Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer Dementia
    • Sleegers K, Bettens K, Brouwers N, Engelborghs S, Miegroet H, De Deyn PP, et al. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer Dementia Hum Mutat.2008, 1036(29): 338-344.
    • (2008) Hum Mutat , vol.1036 , Issue.29 , pp. 338-344
    • Sleegers, K.1    Bettens, K.2    Brouwers, N.3    Engelborghs, S.4    Miegroet, H.5    De Deyn, P.P.6
  • 28
    • 60549101350 scopus 로고    scopus 로고
    • GAB2 as an Alzheimer Disease susceptibility gene: Follow- up of genomewide association results
    • Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, et al. GAB2 as an Alzheimer Disease susceptibility gene: follow- up of genomewide association results. Arch Neurol 2009, 66 (2): 250-254.
    • (2009) Arch Neurol , vol.66 , Issue.2 , pp. 250-254
    • Schjeide, B.M.1    Hooli, B.2    Parkinson, M.3    Hogan, M.F.4    Divito, J.5    Mullin, K.6
  • 29
    • 67349256894 scopus 로고    scopus 로고
    • The GAB2 gene and the risk of Alzheimer's disease: Replication and meta-analysis
    • Ikram MA, Liu F, Oostra BA, Hofman A, van Duijin CM, Breteler MM. The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis. Biol Psychiatry 2009, 65(11): 995-999.
    • (2009) Biol Psychiatry , vol.65 , Issue.11 , pp. 995-999
    • Ma, I.1    Liu, F.2    Oostra, B.A.3    Hofman, A.4    Van Duijin, C.M.5    Breteler, M.M.6
  • 31
    • 67349266214 scopus 로고    scopus 로고
    • GAB2 is not associated with late-onset Alzheimer's disease in Japanese
    • Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, et al. GAB2 is not associated with late-onset Alzheimer's disease in Japanese. Eur J Hum Genet 2009, 17(5): 682-686.
    • (2009) Eur J Hum Genet , vol.17 , Issue.5 , pp. 682-686
    • Miyashita, A.1    Arai, H.2    Asada, T.3    Imagawa, M.4    Shoji, M.5    Higuchi, S.6
  • 33
    • 40849102705 scopus 로고    scopus 로고
    • Association study of the GAB2 gene with the risk of developing Alzheimer's disease
    • Chapuis J, Hannequin D, Pasquier F, Bentham P, Brice A, Leber I, et al. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol Dis 2008, 30(1): 103-106.
    • (2008) Neurobiol Dis , vol.30 , Issue.1 , pp. 103-106
    • Chapuis, J.1    Hannequin, D.2    Pasquier, F.3    Bentham, P.4    Brice, A.5    Leber, I.6
  • 34
    • 77955946251 scopus 로고    scopus 로고
    • GAB2 is not associated with late on-set Alzheimer's disease in Chinese Han
    • Lin K, Tang M, Han H, Guo Y, Lin Y, Ma C. GAB2 is not associated with late on-set Alzheimer's disease in Chinese Han. Neurobiol Dis 2009, 30(1): 103-106.
    • (2009) Neurobiol Dis , vol.30 , Issue.1 , pp. 103-106
    • Lin, K.1    Tang, M.2    Han, H.3    Guo, Y.4    Lin, Y.5    Ma, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.