Inhibition of the antigen-induced activation of RBL-2H3 cells by Gab2 siRNA

Cellular and Molecular Immunology

Volumn 5, Issue 6, 2008, Pages 433-438

  Huang, Feng ^a   Tong, Xiaoyun ^b   Deng, Huaming ^a   Fu, Liangqing ^c   Zhang, Ronghua ^a  

^a JINAN UNIVERSITY   (China)

^b YUNNAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Beijing 307 Hospital   (China)

Author keywords

Gab2; RBL 2H3 cell; RNA interference

Indexed keywords

ANTIGEN; BETA N ACETYLHEXOSAMINIDASE; CALCIUM; CYTOKINE; GAB2 PROTEIN, RAT; IMMUNOGLOBULIN E RECEPTOR; PHOSPHOPROTEIN; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; CALCIUM SIGNALING; CELL LINE; DEGRANULATION; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HISTAMINE RELEASE; IMMUNOLOGY; MAST CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT;

ANIMALS; ANTIGENS; BETA-N-ACETYLHEXOSAMINIDASES; CALCIUM; CALCIUM SIGNALING; CELL DEGRANULATION; CELL LINE; CYTOKINES; GENE EXPRESSION REGULATION; HISTAMINE RELEASE; MAST CELLS; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RECEPTORS, IGE; RNA, SMALL INTERFERING;

EID: 62449265137     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2008.54     Document Type: Article

References (18)

1. McDermott RA, Porterfield HS, El Mezayen R, et al. Contribution of Ara h 2 to peanut-specific, immunoglobulin E-mediated, cell activation. Clin Exp Allergy. 2007;37:752-763. (Pubitemid 46643059)
2. Marchand F, Mecheri S, Guilloux L, Iannascoli B, Weyer A, Blank U. Human serum IgE-mediated mast cell degranulation shows poor correlation to allergen-specific IgE content. Allergy. 2003;58:1037-1043. (Pubitemid 37260348)
3. Maffucci T, Falasca M. Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositideprotein co-operative mechanism. FEBS Lett. 2001;506:173-179. (Pubitemid 32964808)
4. Gu H, Saito K, Klaman LD, et al. Essential role for Gab2 in the allergic response. Nature. 2001;412:186-190. (Pubitemid 32674715)
5. Nishida K, Yamasaki S, Ito Y, et al. FcεRI-mediated mast cell degranulation requires calcium-independent microtubuledependent translocation of granules to the plasma membrane. J Cell Biol. 2005;170:115-126. (Pubitemid 40994101)
6. Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A. 2002;99:6047-6052. (Pubitemid 34493262)
7. Matsuda H, Tewtrakul S, Morikawa T, Yoshikawa M. Antiallergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigeninduced degranulation and their effects on the release of TNF-α and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 2004;12:4871-4876. (Pubitemid 39164395)
8. Blank U, Rivera J. The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol. 2004;25:266-273. (Pubitemid 38501673)
9. Parravicini V, Gadina M, Kovarova M, et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol. 2002;3:741-748.
10. Yu M, Lowell CA, Neel BG, et al. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FceRI. J Immunol. 2006;176:2421-2429. (Pubitemid 43201692)
11. Fukao T, Terauchi Y, Kadowaki T, et al. Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies. J Mol Med. 2003;81:524-535. (Pubitemid 37214991)
12. Chang EY, Szallasi Z, Acs P, et al. Functional effects of overexpression of protein kinase C-α,-β,-δ,-ε, and-τ in the mast cell line RBL-2H3. J Immunol. 1997;159:2624-2632. (Pubitemid 127681280)
13. Frossi B, Rivera J, Hirsch E, Pucillo C. Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol. 2007;178:2549-2555. (Pubitemid 46233457)
14. Hirasawa N, Sato Y, Fujita Y, Ohuchi K. Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells. Biochim Biophys Acta. 2000;1456:45-55. (Pubitemid 30009737)
15. Koranteng RD, Swindle EJ, Davis BJ, et al. Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. Clin Exp Immunol. 2004;137:81-87. (Pubitemid 38869781)
16. Boudreau RT, Hoskin DW, Lin TJ. Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcεRI-mediated activation: involvement of p38 MAPK. J Leukoc Biol. 2004;76:1075-1081. (Pubitemid 39458719)
17. Sada K, Miah SM, Maeno K, Kyo S, Qu X, Yamamura H. Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood. 2002;100:2138-2144. (Pubitemid 35001249)
18. Ishizuka T, Chayama K, Takeda K, et al. Mitogen-activated protein kinase activation through Fc6 receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells. J Immunol. 1999;162:2087-2094. (Pubitemid 29288829)