Epithelial to mesenchymal transition: The doorway to metastasis in human lung cancers

Journal of Thoracic and Cardiovascular Surgery

Volumn 140, Issue 3, 2010, Pages 505-513

  Denlinger, Chadrick E ^a   Ikonomidis, John S ^a   Reed, Carolyn E ^a   Spinale, Francis G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYTOKERATIN; ERLOTINIB; FIBRONECTIN; GELATINASE A; GLYCOGEN SYNTHASE KINASE 3BETA; MATRILYSIN; MATRIX METALLOPROTEINASE 14; NERVE CELL ADHESION MOLECULE; PROTEIN C JUN; SMAD PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR ALPHA RECEPTOR; UVOMORULIN; VIMENTIN; WNT PROTEIN; TUMOR MARKER;

ADULT; BLADDER CANCER; CANCER CELL; CANCER GROWTH; CANCER INVASION; CANCER MORTALITY; CANCER RECURRENCE; CANCER THERAPY; CELL CYCLE ARREST; CELL JUNCTION; CELL POPULATION; CELL STRUCTURE; COLORECTAL CANCER; DNA METHYLATION; DORSAL RUFFLE; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GROWTH DISORDER; HUMAN; INFLAMMATION; INVADOPODIA; LUNG CARCINOMA; LUNG METASTASIS; LUNG NON SMALL CELL CANCER; MESENCHYME CELL; NEURAL CREST CELL; PODOSOME; PRIMARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SIGNAL TRANSDUCTION; STOMACH CANCER; CELL TRANSDIFFERENTIATION; EPITHELIUM CELL; LUNG TUMOR; MESODERM; METABOLISM; PATHOLOGY; PHENOTYPE; SECONDARY; TUMOR EMBOLISM; TUMOR INVASION;

CELL TRANSDIFFERENTIATION; EPITHELIAL CELLS; HUMANS; LUNG NEOPLASMS; MESODERM; NEOPLASM INVASIVENESS; NEOPLASTIC CELLS, CIRCULATING; PHENOTYPE; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 77955951109     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2010.02.061     Document Type: Editorial

References (49)

1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and T. Murray Cancer statistics, 2008 CA Cancer J Clin 58 2008 71 96
2. A. Sandler, R. Gray, M.C. Perry, J. Brahmer, J.H. Schiller, and A. Dowlati Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer N Engl J Med 355 2006 2542 2550 Erratum in: N Engl J Med. 2007;356:318.
3. A.A. Joy, and C.A. Butts Extending outcomes: epidermal growth factor receptor-targeted monoclonal antibodies in non-small cell lung cancer Clin Lung Cancer 1010 Suppl. 1 2009 S24 S29
4. T. Brabletz, A. Jung, S. Spaderna, F. Hlubek, and T. Kirchner Opinion: migrating cancer stem cells - an integrated concept of malignant tumor progression Nat Rev Cancer 5 2005 744 749
5. A. Voulgari, and A. Pintzas Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic Biochim Biophys Acta 1796 2009 75 90
6. J. Thiery Epithelial-mesenchymal transition in development and pathogenesis Curr Opin Cell Biol 15 2003 740 746
7. H. Ueno, J. Murphy, J.R. Jass, H. Mochizuki, and I.C. Talbot Tumor 'budding' as an index to estimate the potential of aggressiveness in rectal cancer Histopathology 40 2002 127 132
8. Bruyere F, Namdarian B, Corcoran NM, Pedersen J, Ockrim J, Voelzke BB, et al. Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers. Urol Oncol. Epub 2009 Jan 20.
9. A. Soltermann, V. Tischler, S. Arbogast, J. Braun, N. Probst-Hensch, and W. Weder Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer Clin Cancer Res 14 2008 7430 7437
10. J. Shih Transcription repressor slug promotes carcinoma and predicts outcome of patients with lung adenocarcinoma Clin Cancer Res 11 2005 8070 8078
11. M.A. Kim, H.S. Lee, H.E. Lee, J.H. Kim, H.K. Yang, and W.H. Kim Prognostic importance of epithelial-mesenchymal-related protein expression in gastric carcinoma Histopathology 54 2009 442 451
12. T. Arumugam, V. Ramachandran, K.F. Fournier, H. Wang, L. Marquis, and J.L. Abbruzzese Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer Cancer Res 69 2009 5820 5828
13. Y. Haddad, W. Choi, and D.J. McConkey Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epithelial growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines Clin Cancer Res 15 2009 532 542
14. F. Prall, H. Nizze, and M. Barten Tumor budding as prognostic factor in stage I/II colorectal carcinoma Histopathology 47 2005 17 24
15. H. Oka, H. Shiozaki, K. Kobayashi, M. Inoue, H. Tahara, and T. Kobayashi Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis Cancer Res 53 1993 1696 1701
16. M. Guarino, B. Rubino, and G. Ballabia The role of epithelial-mesenchymal transition in cancer pathology Pathology 39 2007 305 318
17. S. Hirohashi Inactivation of the E-cadherin-mediated cell adhesion system in human cancers Am J Pathol 153 1998 333 339
18. W.J. Nelson, and R. Nusse Convergence of Wnt, β-catenin, and cadherin pathways Science 303 2004 1483 1487
19. M. Connacci-Sorrell, I. Simcha, T. Ben-Yedidia, J. Blechman, P. Savagner, and A. Ben-Ze'ev Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK J Cell Biol 163 2003 847 857
20. K. Tomita, A. van Bokhoven, G.J. van Leenders, E.T. Ruijter, C.F. Jansen, and M.J. Bussemakers Cadherin switching in human prostate cancer progression Cancer Res 60 2000 3650 3654
21. K. Suyama, I. Shapiro, M. Guttman, and R.B. Hazan A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor Cancer Cell 2 2002 301 313
22. R. Schmidmaier, and P. Baumann Anti-adhesion evolves to a promising therapeutic concept in oncology Curr Med Chem 15 2008 978 990
23. G. Moreno-Bueno, E. Cubillo, D. Sarrió, H. Peinado, and S.M. Rodríguez-Pinilla Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition Cancer Res 66 2006 9543 9556
24. V. Goede, L. Brogelli, M. Ziche, and H.G. Augustin Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 Int J Cancer 82 1999 765 770
25. Y. Hasegawa, S. Takanashi, Y. Kanehira, T. Tsushima, T. Imai, and K. Okumura Transforming growth factor-β1 level correlates with angiogenesis tumor progression, and prognosis in patients with nonsmall cell lung carcinoma Cancer 91 2001 964 971
26. A. Nawshad, D. Lagamba, A. Polad, and E.D. Hay Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis Cells Tissues Organs 179 2005 11 23
27. M.D. Lacher, M.I. Tiirikainen, E.F. Saunier, C. Christian, M. Anders, and M. Oft Transforming growth factor-β receptor inhibition enhances adenoviral infectability of carcinoma cells via upregulation of Coxsackie and adenovirus receptor in conjunction with reversal of epithelial-mesenchymal transition Cancer Res 66 2006 1648 1657
28. L. Yu, M.D. Hebert, and Y.E. Zhang TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses EMBO J 21 2002 3749 3759
29. N.A. Bhowmick, M. Ghiassi, A. Bakin, M. Aakre, C.A. Lundquist, and M.E. Engel Transforming factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependant mechanism Mol Biol Cell 12 2001 27 36
30. N.J. Sullivan, A.K. Sasser, A.E. Axel, F. Vesuna, V. Raman, and N. Ramirez Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells Oncogene 28 33 2009 2940 2947
31. R. Salgado, S. Junius, I. Benoy, P. Van Dam, P. Vermeulen, and E. Van Marck Circulating interleukin-6 predicts survival in patients with metastatic breast cancer Int J Cancer 103 2003 642 646
32. L. Enewold, L.E. Mechanic, E.D. Bowman, Y.L. Zheng, Z. Yu, and G. Trivers Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians Cancer Epidemiol Biomarkers Prev 18 2009 215 222
33. M. Seike, N. Yanaihara, E.D. Bowman, K.A. Zanetti, A. Budhu, and K. Kumamoto Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier J Natl Cancer Inst 99 2007 1257 1269
34. E.I. Duryuginia, and J.P. Quigley Matrix metalloproteinase and tumor metastasis Cancer Metastasis 25 2006 9 34
35. R. Buccione, J.D. Orth, and M.A. McNiven Foot and mouth: podosomes, invadopodia and circular dorsal ruffles Nature Rev Mol Cell Biol 5 2004 647 657
36. S. Mandal, K.R. Johnson, and M.J. Wheelock TGF-β induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways Exp Cell Res 314 2008 3478 3493
37. C.B. Basbaum, and Z. Werb Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface Curr Opin Cell Biol 8 1996 731 738
38. W.T. Chen Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells J Exp Zool 251 1989 167 185
39. M. Seiki Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion Cancer Letter 194 2003 1 11
40. J. Ueda, M. Kajita, N. Suenaga, K. Jugii, and M. Seika Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors Oncogene 22 2003 8716 8722
41. H. Sato, Y. Takino, J. Okada, J. Cao, A. Shinagawa, and E. Yamamoto A matrix metalloproteinase expressed on the surface of invasive tumor cells Nature 370 1994 61 65
42. U.B. Hofmann, A.A. Eggert, K. Blass, E.B. Brocker, and J.C. Becker Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation Cancer Res 63 2003 8221 8225
43. Takkunen M, Hukkanen M, Liljeström M, Grenman R, Virtanen I. Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med. Epub 2009 Jul 28.
44. A. Jung, M. Schrauder, U. Oswald, C. Knoll, P. Sellberg, and R. Palmqvist The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4A and is a region of low proliferation Am J Pathol 159 2001 1613 1617
45. C.T. Hu, J.R. Wu, C.C. Cheng, C.C. Cheng, and W.S. Wu The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2 J Biomed Sci 15 2008 343 355
46. N. Barker, and H. Clevers Tumor environment: a potent driving force in colorectal cancer? Trends Mol Med 7 2001 535 537
47. T. Brabletz, A. Jung, S. Reu, M. Porzner, F. Hlubek, and A.L. Kunz-Schughart Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment Proc Natl Acad Sci 98 2001 10356 10361
48. F.C. Bidard, A. Vincent-Salomon, B. Sigal-Zafrani, M. Rodrigues, V. Diéras, and L. Mignot Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapse Clin Exp Metastasis 25 2008 871 875
49. M. Wrage, S. Rousaari, P.P. Eijk, J.T. Kaifi, J. Hollmén, and E.F. Yekebas Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion Clin Cancer Res 15 2009 1566 1574