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Volumn 10, Issue SUPPL.1, 2009, Pages

Extending outcomes: Epidermal growth factor receptor-targeted monoclonal antibodies in non-small-cell lung cancer

Author keywords

Cetuximab; Immunotherapy; Panitumumab; Predictive markers; Targeted therapy; Tyrosine kinase inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; MATUZUMAB; MONOCLONAL ANTIBODY; PANITUMUMAB; RADIOSENSITIZING AGENT;

EID: 67449102197     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.3816/CLC.2009.s.004     Document Type: Article
Times cited : (6)

References (67)
  • 1
    • 53749097825 scopus 로고    scopus 로고
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials
    • NSCLC Meta-Analyses Collaborative Group
    • NSCLC Meta-Analyses Collaborative Group. Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol 2008; 26:4617-25.
    • (2008) J Clin Oncol , vol.26 , pp. 4617-4625
  • 3
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin®) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • DOI 10.1634/theoncologist.12-6-713
    • Cohen MH, Gootenberg J, Keegan P, et al. FDA drug approval summary: bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist 2007; 12:713-8. (Pubitemid 47036205)
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 4
    • 35548962413 scopus 로고    scopus 로고
    • Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-sqamous nonsmall cell lung cancer (NSCLC): BO17704
    • (Abstract LBA7514)
    • Manegold C, von Pawel J, Zatloukal P, et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-sqamous nonsmall cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007; 25(18 suppl):388s (Abstract LBA7514).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 8
    • 34447264101 scopus 로고    scopus 로고
    • Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): The CRYSTAL trial
    • (Abstract 4000)
    • Van Cutsem EN, Nowacki M, Lang I, et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC):the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Van Cutsem, E.N.1    Nowacki, M.2    Lang, I.3
  • 12
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005; 23:5892-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 15
    • 11244258222 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition strategies in oncology
    • DOI 10.1677/erc.1.00600
    • Harari PM. Epidermal growth factor receptor inhibition strategies in oncology. Endocr Relat Cancer 2004; 11:689-708. (Pubitemid 40065545)
    • (2004) Endocrine-Related Cancer , vol.11 , Issue.4 , pp. 689-708
    • Harari, P.M.1
  • 16
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • DOI 10.1053/j.seminoncol.2006.04.003, PII S0093775406001771
    • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006; 33:369-85. (Pubitemid 44142736)
    • (2006) Seminars in Oncology , vol.33 , Issue.4 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 17
    • 46349097694 scopus 로고    scopus 로고
    • EGFR-targeting drugs in combination with cytotoxic agents: From bench to bedside, a contrasted reality
    • DOI 10.1038/sj.bjc.6604373, PII 6604373
    • Milano G, Spano JP, Leyland-Jones B. EGFR-targeting drugs in combination with cytotoxic agents: from bench to bedside, a contrasted reality. Br J Cancer 2008; 99:1-5. (Pubitemid 351920216)
    • (2008) British Journal of Cancer , vol.99 , Issue.1 , pp. 1-5
    • Milano, G.1    Spano, J.-P.2    Leyland-Jones, B.3
  • 18
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • DOI 10.1158/0008-5472.CAN-06-1684
    • Morgillo F, Woo JK, Kim ES, et al. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res 2006; 66:10100-11. (Pubitemid 44672064)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.-Y.5
  • 19
    • 0345098554 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway and its inhibition as anticancer therapy
    • DOI 10.1358/dot.2003.39.1.799432
    • Janmaat ML, Giaccone G. The epidermal growth factor receptor pathway and its inhibition as anticancer therapy. Drugs Today (Barc) 2003; 39(suppl C):61-80. (Pubitemid 37509402)
    • (2003) Drugs of Today , vol.39 , Issue.SUPPL. C , pp. 61-80
    • Janmaat, M.L.1    Giaccone, G.2
  • 20
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-25.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 21
    • 0035027576 scopus 로고    scopus 로고
    • The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma
    • DOI 10.1046/j.1525-1438.2001.011002119.x
    • Skirnisdottir I, Sorbe B, Seidal T. The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma. Int J Gynecol Cancer 2001; 11:119-29. (Pubitemid 32381660)
    • (2001) International Journal of Gynecological Cancer , vol.11 , Issue.2 , pp. 119-129
    • Skirnisdottir, I.1    Sorbe, B.2    Seidal, T.3
  • 22
    • 34250756492 scopus 로고    scopus 로고
    • Her signaling in pancreatic cancer
    • DOI 10.1517/14712598.7.6.823
    • Burtness B. Her signaling in pancreatic cancer. Expert Opin Biol Ther 2007; 7:823-9. (Pubitemid 46954429)
    • (2007) Expert Opinion on Biological Therapy , vol.7 , Issue.6 , pp. 823-829
    • Burtness, B.1
  • 26
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • DOI 10.1016/S0163-7258(98)00045-X, PII S016372589800045X
    • Woodburn JR. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999; 82:241-50. (Pubitemid 29255919)
    • (1999) Pharmacology and Therapeutics , vol.82 , Issue.2-3 , pp. 241-250
    • Woodburn, J.R.1
  • 27
    • 0027170357 scopus 로고
    • Evidence for a role of EGF receptor in the progression of human lung carcinoma
    • Pavelic K, Banjac Z, Pavelic J, et al. Evidence for a role of EGF receptor in the progression of human lung carcinoma. Anticancer Res 1993; 13:1133-7. (Pubitemid 23247476)
    • (1993) Anticancer Research , vol.13 , Issue.4 , pp. 1133-1137
    • Pavelic, K.1    Banjac, Z.2    Pavelic, J.3    Spaventi, S.4
  • 28
    • 0030297662 scopus 로고    scopus 로고
    • A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer
    • DOI 10.1016/S0959-8049(96)00243-2, PII S0959804996002432
    • Fujino S, Enokibori T, Tezuka N, et al. A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. Eur J Cancer 1996; 32A:2070-4. (Pubitemid 26419455)
    • (1996) European Journal of Cancer Part A , vol.32 , Issue.12 , pp. 2070-2074
    • Fujino, S.1    Enokibori, T.2    Tezuka, N.3    Asada, Y.4    Inoue, S.5    Kato, H.6    Mori, A.7
  • 29
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002; 7(suppl 4):2-8. (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 30
    • 3843128786 scopus 로고    scopus 로고
    • Technology evaluation: Matuzumab, merck kgaa
    • Kim T. Technology evaluation: Matuzumab, Merck KGaA. Curr Opin Mol Ther 2004; 6:96-103.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 96-103
    • Kim, T.1
  • 31
    • 84860557028 scopus 로고    scopus 로고
    • A phase i study of epidermal growth factor receptor (egfr) antibody matuzumab (emd 72000) in combination with paclitaxel in subjects with egfr-positive advanced non-small cell lung cancer
    • October 5
    • Bokemeyer C, Kollmannsberger C, Schittenhelm M, et al. A phase I study of epidermal growth factor receptor (EGFR) antibody Matuzumab (EMD 72000) in combination with paclitaxel in subjects with EGFR-positive advanced non-small cell lung cancer. Paper presented at: Deutsche Gesellschaft fur Hamatologie und Onkologie; October 5, 2004.
    • (2004) Deutsche Gesellschaft fur Hamatologie und Onkologie
    • Bokemeyer, C.1    Kollmannsberger, C.2    Schittenhelm, M.3
  • 32
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • DOI 10.1016/S1040-8428(00)00134-7, PII S1040842800001347
    • Yang XD, Jia XC, Corvalan JR, et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001; 38:17-23. (Pubitemid 32194591)
    • (2001) Critical Reviews in Oncology/Hematology , vol.38 , Issue.1 , pp. 17-23
    • Yang, X.-D.1    Jia, X.-C.2    Corvalan, J.R.F.3    Wang, P.4    Davis, C.G.5
  • 33
    • 40949091368 scopus 로고    scopus 로고
    • U.S. food and drug administration approval: Panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens
    • DOI 10.1158/1078-0432.CCR-07-1354
    • Giusti RM, Shastri K, Pilaro AM, et al. U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin Cancer Res 2008; 14:1296-302. (Pubitemid 351413907)
    • (2008) Clinical Cancer Research , vol.14 , Issue.5 , pp. 1296-1302
    • Giusti, R.M.1    Shastri, K.2    Pilaro, A.M.3    Fuchs, C.4    Cordoba-Rodriguez, R.5    Koti, K.6    Rothmann, M.7    Men, A.Y.8    Zhao, H.9    Hughes, M.10    Keegan, P.11    Weiss, K.D.12    Pazdur, R.13
  • 34
    • 45349097237 scopus 로고    scopus 로고
    • Panitumumab: Human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer
    • DOI 10.1016/j.clinthera.2008.01.014, PII S0149291808000623
    • Wu M, Rivkin A, Pham T. Panitumumab: human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer. Clin Ther 2008; 30:14-30. (Pubitemid 351843429)
    • (2008) Clinical Therapeutics , vol.30 , Issue.1 , pp. 14-30
    • Wu, M.1    Rivkin, A.2    Pham, T.3
  • 35
    • 16844375378 scopus 로고    scopus 로고
    • Clinical experience with monoclonal antibodies to epidermal growth factor receptor
    • Calvo E, Rowinsky EK. Clinical experience with monoclonal antibodies to epidermal growth factor receptor. Curr Oncol Rep 2005; 7:96-103. (Pubitemid 40485464)
    • (2005) Current Oncology Reports , vol.7 , Issue.2 , pp. 96-103
    • Calvo, E.1    Rowinsky, E.K.2
  • 36
    • 51449117743 scopus 로고    scopus 로고
    • Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer
    • Kruser TJ, Armstrong EA, Ghia AJ, et al. Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer. Int J Radiat Oncol Biol Phys 2008; 72:534-42.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 534-542
    • Kruser, T.J.1    Armstrong, E.A.2    Ghia, A.J.3
  • 37
    • 4444368283 scopus 로고    scopus 로고
    • ABX-EGF in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7083)
    • Crawford J Sandler AB, Hammond LA, et al. ABX-EGF in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; 23:634 (Abstract 7083).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 634
    • Crawford, J.1    Sandler, A.B.2    Hammond, L.A.3
  • 38
    • 33644975044 scopus 로고    scopus 로고
    • Panitumumab, a fully human monoclonal antibody, combined with paclitaxel and carboplatin versus paclitaxel and carboplatin alone for first line advanced non-small cell lung cancer (NSCLC): A primary analysis
    • (Abstract 1123)
    • Crawford J, Swanson P, Prager D, et al. Panitumumab, a fully human monoclonal antibody, combined with paclitaxel and carboplatin versus paclitaxel and carboplatin alone for first line advanced non-small cell lung cancer (NSCLC): a primary analysis. Eur J Cancer 2005; 3(suppl 2):324 (Abstract 1123).
    • (2005) Eur J Cancer , vol.3 , Issue.SUPPL. 2 , pp. 324
    • Crawford, J.1    Swanson, P.2    Prager, D.3
  • 39
    • 33750940321 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7119)
    • Blumenschein GR Jr, Sandler A, O'Rourke T, et al. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(18 suppl):393s (Abstract 7119).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Blumenschein Jr., G.R.1    Sandler, A.2    Orrourke, T.3
  • 40
    • 55849108694 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer
    • (Abstract 14057)
    • Crawford JB, Burris H, Stephenson J, et al. Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer. J Clin Oncol 2007; 25(18 suppl):616s (Abstract 14057).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Crawford, J.B.1    Burris, H.2    Stephenson, J.3
  • 42
    • 33751580192 scopus 로고    scopus 로고
    • A phase II of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer
    • (Abstract 2581)
    • Kim ES, Tran H, Mauer AM, et al. A phase II of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer. Proc Am Soc Clin Oncol 2003; 22:642 (Abstract 2581).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 642
    • Kim, E.S.1    Tran, H.2    Mauer, A.M.3
  • 44
    • 33144481184 scopus 로고    scopus 로고
    • Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced nonsmall-cell lung cancer
    • Robert F, Blumenschein G, Herbst RS, et al. Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced nonsmall-cell lung cancer. J Clin Oncol 2005; 23:9089-96.
    • (2005) J Clin Oncol , vol.23 , pp. 9089-9096
    • Robert, F.1    Blumenschein, G.2    Herbst, R.S.3
  • 45
    • 37649016023 scopus 로고    scopus 로고
    • A phase II randomized selection trial evaluating concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in patients with advanced non-small cell lung cancer (NSCLC): Final report of SWOG 0342
    • (Abstract 7545)
    • Herbst RS, Chansky K, Kelly K, et al. A phase II randomized selection trial evaluating concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in patients with advanced non-small cell lung cancer (NSCLC): final report of SWOG 0342. J Clin Oncol 2007; 25(18 suppl):395s (Abstract 7545).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Herbst, R.S.1    Chansky, K.2    Kelly, K.3
  • 47
    • 37649022615 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer
    • Butts CA, Bodkin D, Middleman EL, et al. Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, as first-line therapy for patients with advanced or metastatic non small-cell lung cancer. J Clin Oncol 2007; 25:5777-84.
    • (2007) J Clin Oncol , vol.25 , pp. 5777-5784
    • Butts, C.A.1    Bodkin, D.2    Middleman, E.L.3
  • 48
    • 51349109631 scopus 로고    scopus 로고
    • FLEX: A randomized, multicenter, phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC)
    • (Abstract 3)
    • Piker RS, Szczesna A, von Pawel J, et al. FLEX: a randomized, multicenter, phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008; 26(15 suppl):6s (Abstract 3).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Piker, R.S.1    Szczesna, A.2    Von Pawel, J.3
  • 49
    • 39849111354 scopus 로고    scopus 로고
    • A randomized multicenter phase iii study of cetuximab (erbitux) in combination with taxane/carboplatin versus taxane/ carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (nsclc)
    • (Abstract B3-03)
    • Lynch TJ, Patel T, Dreisbach L, et al. A randomized multicenter phase III study of cetuximab (Erbitux) in combination with Taxane/Carboplatin versus Taxane/ Carboplatin alone as first-line treatment for patients with advanced/metastatic Non-small cell lung cancer (NSCLC). J Thorac Oncol 2007; 2(suppl 4):S340-1 (Abstract B3-03).
    • (2007) J Thorac Oncol , vol.2 , Issue.SUPPL. 4
    • Lynch, T.J.1    Patel, T.2    Dreisbach, L.3
  • 50
    • 84860598339 scopus 로고    scopus 로고
    • Accessed: February 24, 2009
    • ImClone [Press Release]. Available at: http://phx.corporate-ir.net/ phoenix.zhtml?c=97689&p=irol-newsArticle&ID=1192099&highlight=. Accessed: February 24, 2009.
    • ImClone [Press Release]
  • 53
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000; 6:2166-74. (Pubitemid 30399181)
    • (2000) Clinical Cancer Research , vol.6 , Issue.6 , pp. 2166-2174
    • Huang, S.-M.1    Harari, P.M.2
  • 55
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
    • DOI 10.1016/j.radonc.2005.06.022, PII S0167814005002513
    • Dittmann K, Mayer C, Rodemann HP. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol 2005; 76:157-61. (Pubitemid 41725442)
    • (2005) Radiotherapy and Oncology , vol.76 , Issue.2 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.-P.3
  • 56
    • 39449125850 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status
    • DOI 10.1038/sj.bjc.6604222, PII 6604222
    • Akashi Y, Okamoto I, Iwasa T, et al. Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status. Br J Cancer 2008; 98:749-55. (Pubitemid 351272610)
    • (2008) British Journal of Cancer , vol.98 , Issue.4 , pp. 749-755
    • Akashi, Y.1    Okamoto, I.2    Iwasa, T.3    Yoshida, T.4    Suzuki, M.5    Hatashita, E.6    Yamada, Y.7    Satoh, T.8    Fukuoka, M.9    Ono, K.10    Nakagawa, K.11
  • 59
    • 45149102984 scopus 로고    scopus 로고
    • Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023
    • Kelly K, Chansky K, Gaspar LE, et al. Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023. J Clin Oncol 2008; 26:2450-6.
    • (2008) J Clin Oncol , vol.26 , pp. 2450-2456
    • Kelly, K.1    Chansky, K.2    Gaspar, L.E.3
  • 60
    • 51649120733 scopus 로고    scopus 로고
    • KRAS status and efficacy in first line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience
    • (Abstract 2)
    • Van Cutsem E, Lang I, D'haens G, et al. KRAS status and efficacy in first line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience. J Clin Oncol 2008; 26(15 suppl):5s (Abstract 2).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Van Cutsem, E.1    Lang, I.2    D'Haens, G.3
  • 61
    • 34250843259 scopus 로고    scopus 로고
    • Weighing tumor biology in treatment decisions for patients with non-small cell lung cancer
    • Shepherd FA, Rosell R. Weighing tumor biology in treatment decisions for patients with non-small cell lung cancer. J Thorac Oncol 2007; 2(suppl 2):S68-76.
    • (2007) J Thorac Oncol , vol.2 , Issue.SUPPL. 2
    • Shepherd, F.A.1    Rosell, R.2
  • 63
    • 33947412800 scopus 로고    scopus 로고
    • Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor
    • DOI 10.1158/1078-0432.CCR-06-1887
    • Steiner P, Joynes C, Bassi R, et al. Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor. Clin Cancer Res 2007; 13:1540-51. (Pubitemid 46450446)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1540-1551
    • Steiner, P.1    Joynes, C.2    Bassi, R.3    Wang, S.4    Tonra, J.R.5    Hadari, Y.R.6    Hicklin, D.J.7
  • 64
    • 33845973029 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations
    • DOI 10.1074/jbc.M607958200
    • Perez-Torres M, Guix M, Gonzalez A, et al. Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations. J Biol Chem 2006; 281:40183-92. (Pubitemid 46041823)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.52 , pp. 40183-40192
    • Perez-Torres, M.1    Guix, M.2    Gonzalez, A.3    Arteaga, C.L.4
  • 65
    • 49149127726 scopus 로고    scopus 로고
    • Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy
    • Hirsch FR, Herbst RS, Olsen C, et al. Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 2008; 26:3351-7.
    • (2008) J Clin Oncol , vol.26 , pp. 3351-3357
    • Hirsch, F.R.1    Herbst, R.S.2    Olsen, C.3
  • 66
    • 43049122132 scopus 로고    scopus 로고
    • Predicting response of molecular targeted therapies: A still possible challenge?
    • DOI 10.1093/annonc/mdn016
    • Labianca R, Garassino M, Torri V. Predicting response of molecular targeted therapies: a still possible challenge? Ann Oncol 2008; 19:829-30. (Pubitemid 351627296)
    • (2008) Annals of Oncology , vol.19 , Issue.5 , pp. 829-830
    • Labianca, R.1    Garassino, M.2    Torri, V.3
  • 67
    • 43249110958 scopus 로고    scopus 로고
    • Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): A phase I study
    • DOI 10.1097/JTO.0b013e3181653d1b, PII 0124389420080300000010
    • Ramalingam S, Forster J, Naret C, et al. Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study. J Thorac Oncol 2008; 3:258-64. (Pubitemid 351654325)
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.3 , pp. 258-264
    • Ramalingam, S.1    Forster, J.2    Naret, C.3    Evans, T.4    Sulecki, M.5    Lu, H.6    Teegarden, P.7    Weber, M.R.8    Belani, C.P.9


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