Expression of Matrix Metalloproteinases in the Microenvironment of Spontaneous and Experimental Melanoma Metastases Reflects the Requirements for Tumor Formation

Cancer Research

Volumn 63, Issue 23, 2003, Pages 8221-8225

  Hofmann, Uta B ^a   Eggert, Andreas A O ^a   Blass, Katharina ^a   Bröcker, Eva B ^a   Becker, Jürgen C ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG METASTASIS; LYMPH NODE; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; FEMALE; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MELANOMA, EXPERIMENTAL; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 0346365374     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Stetler Stevenson, W. G., Liotta, L. A., and Kleiner, D. E., Jr. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J., 7: 1434-1441, 1993.
2. Nagase, H., and Woessner, J. F., Jr. Matrix metalloproteinases. J. Biol. Chem., 274: 21491-21494, 1999.
3. Woessner, J. F., Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J., 5: 2145-2154, 1991.
4. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (Lond.), 370: 61-65, 1994.
5. Kojima, S., Itoh, Y., Matsumoto, S., Masuho, Y., and Seiki, M. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. FEBS Lett., 480: 142-146, 2000.
6. Nagase, H. Activation mechanisms of matrix metalloproteinases. Biol. Chem., 378: 151-160, 1997.
7. Nakahara, H., Howard, L., Thompson, E. W., Sato, H., Seiki, M., Yeh, Y., and Chen, W. T. Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc. Natl. Acad. Sci. USA, 94: 7959-7964, 1997.
8. Gomez, D. E., Alonso, D. F., Yoshiji, H., and Thorgeirsson, U. P. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur. J. Cell Biol., 74: 111-122, 1997.
9. Kurschat, P., Zigrino, P., Nischt, R., Breitkopf, K., Steurer, P., Klein, C. E., Krieg, T., and Mauch, C. Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines. J. Biol. Chem., 274: 21056-21062, 1999.
10. Hofmann, U. B., Westphal, J. R., Zendman, A. J., Becker, J. C., Ruiter, D. J., and van Muijen, G. Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type matrix metalloproteinase 1 (MT1-MMP) correlate with melanoma progression. J. Pathol., 191: 245-256, 2000.
11. Saad, S., Gottlieb, D. J., Bradstock, K. F., Overall, C. M., and Bendall, L. J. Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from fibroblasts. Cancer Res., 62: 283-289, 2002.
12. Ruiter, D. J., Bogenrieder, T., Elder, D. E., and Herlyn, M. Melanoma-stroma interactions: structural and functional aspects. Lancet Oncol., 3: 35-43, 2002.
13. Stackpole, C. W., Valle, E. F., and Alterman, A. L. B16 melanoma metastasis to an "artificial organ" implant. Cancer Res., 51: 2444-2450, 1991.
14. Hofmann, U. B., Westphal, J. R., Waas, E. T., Zendman, A. J. W., Cornelissen, I. M. H. A., Ruiter, D. J., and van Muijen, G. N. P. Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression. Br. J. Cancer, 81: 774-782, 1999.
15. Ferrier, C. M., van Muijen, G. N. P., and Ruiter, D. J. Proteases in cutaneous melanoma. Ann. Med., 30: 431-442, 1998.
16. Hofmann, U. B., Westphal, J. R., van Muijen, G. N. P., and Ruiter, D. J. Matrix metalloproteinases in human melanoma. Review article. J. Investig. Dermatol., 337-344, 2000.
17. Kurschat, P., Wickenhauser, C., Groth, W., Krieg, T., and Mauch, C. Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography. J. Pathol., 197: 179-187, 2002.
18. Butler, G. S., Butler, M. J., Atkinson, S. J., Will, H., Tamura, T., van-Westrum, S. S., Crabbe, T., Clements, J., d'Ortho, M. P., and Murphy, G. The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study. J. Biol. Chem., 273: 871-880, 1998.
19. Khokha, R. Suppression of the tumorigenic and metastatic abilities of murine B16F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J. Natl. Cancer Inst., 86: 299-304, 1994.
20. Ahonen, M., Baker, A. H., and Kähäri, V. M. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res., 58: 2310-2315, 1998.
21. Valente, P., Fassina, G., Melchiori, A., Masiello, L., Cilli, M., Vacca, A., Onisto, M., Santi, L., Stetler Stevenson, W. G., and Albini, A. TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis. Int. J. Cancer, 75: 246-253, 1998.
22. Morrison, C. J., Butler, G. S., Bigg, H. F., Roberts, C. R., Soloway, P. D., and Overall, C. M. Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. J. Biol. Chem., 276: 47402-47410, 2001.
23. McCawley, L. J., and Matrisian, L. M. Tumor progression: defining the soil round the tumor seed. Curr. Biol., 11: R25-R27, 2001.
24. Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., and Itohara, S. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res., 58: 1048-1051, 1998.
25. Li, R., Huang, L., Guo, H., and Toole, B. P. Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts. J. Cell Physiol., 186: 371-379, 2001.
26. Sun, J., and Hemler, M. E. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res., 61: 2276-2281, 2001.
27. van den Oord, J. J., Paemen, L., Opdenakker, G., and de Wolf Peeters, C. Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin. Am. J. Pathol., 151: 665-670, 1997.
28. MacDougall, J. R., Bani, M. R., Lin, Y., Rak, J., and Kerbel, R. S. The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells. Cancer Res., 55: 4174-4181, 1995.
29. Itoh, T., Tanioka, M., Matsuda, H., Nishimoto, H., Yoshioka, T., Suzuki, R., and Uehira, M. Experimental metastasis is suppressed in MMP-9-deficient mice. Clin. Exp. Metastasis, 17: 177-181, 1999.
30. MacDougall, J. R., Bani, M. R., Lin, Y., Muschel, R. J., and Kerbel, R. S. 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression. Br. J. Cancer, 80: 504-512, 1999.