메뉴 건너뛰기




Volumn 78, Issue 1, 2010, Pages 205-212

Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation

Author keywords

Ionizing radiation; Pancreatic cancer; RalA; RalB; RalBP1

Indexed keywords

APOPTOSIS; CANCER CELLS; CELL LINES; CELLULAR RESPONSE; CLONOGENIC SURVIVAL ASSAYS; COLONY FORMATION; DNA BREAKS; DNA REPAIR; EXOCYST COMPLEX; FORMING ABILITY; GTPASES; ISOFORMS; ONCOGENIC ACTIVATION; PANCREATIC CANCERS; POLY(ADP-RIBOSE) POLYMERASE; RADIATION RESPONSE; RADIORESISTANCE; RALA; RALB; RALBP1; SHORT HAIRPIN RNA; STABLE EXPRESSION; TUMOR GROWTH; WHOLE-BODY;

EID: 77955921327     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.03.023     Document Type: Article
Times cited : (20)

References (50)
  • 2
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • A.F. Hezel, A.C. Kimmelman, and B.Z. Stanger Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev 20 2006 1218 1249
    • (2006) Genes Dev , vol.20 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 3
    • 0032522849 scopus 로고    scopus 로고
    • Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
    • E.J. Bernhard, W.G. Mckenna, and A.D. Hamilton Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes Cancer Res 58 1998 1754
    • (1998) Cancer Res , vol.58 , pp. 1754
    • Bernhard, E.J.1    McKenna, W.G.2    Hamilton, A.D.3
  • 4
    • 0034548724 scopus 로고    scopus 로고
    • Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
    • E.J. Bernhard, E. Stanbridge, and S. Gupta Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines Cancer Res 60 2000 6597
    • (2000) Cancer Res , vol.60 , pp. 6597
    • Bernhard, E.J.1    Stanbridge, E.2    Gupta, S.3
  • 5
    • 3042857537 scopus 로고    scopus 로고
    • The influence of Ras pathway signaling on tumor radiosensitivity
    • I.A. Kim, A.T. Fernandes, and A.K. Gupta The influence of Ras pathway signaling on tumor radiosensitivity Cancer Metastasis Rev 23 2004 227 236
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 227-236
    • Kim, I.A.1    Fernandes, A.T.2    Gupta, A.K.3
  • 6
    • 0344586930 scopus 로고    scopus 로고
    • Targeting tumor cells by enhancing radiation sensitivity
    • W.G. McKenna, and R.J. Muschel Targeting tumor cells by enhancing radiation sensitivity Genes Chromosomes Cancer 38 2003 330 338
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 330-338
    • McKenna, W.G.1    Muschel, R.J.2
  • 7
    • 0141869078 scopus 로고    scopus 로고
    • The RAS signal transduction pathway and its role in radiation sensitivity
    • W.G. McKenna, R.J. Muschel, and A.K. Gupta The RAS signal transduction pathway and its role in radiation sensitivity Oncogene 22 2003 5866 5875
    • (2003) Oncogene , vol.22 , pp. 5866-5875
    • McKenna, W.G.1    Muschel, R.J.2    Gupta, A.K.3
  • 8
    • 0034989131 scopus 로고    scopus 로고
    • Ras regulation of radioresistance in cell culture
    • A.K. Gupta, V.J. Bakanauskas, and W.G. McKenna Ras regulation of radioresistance in cell culture Meth Enzymol 333 2001 284 290
    • (2001) Meth Enzymol , vol.333 , pp. 284-290
    • Gupta, A.K.1    Bakanauskas, V.J.2    McKenna, W.G.3
  • 9
    • 24944573845 scopus 로고    scopus 로고
    • Pancreatic cancer cell radiation survival and prenyltransferase inhibition: Te role of K-Ras
    • T.B. Brunner, K.A. Cengel, and S.M. Hahn Pancreatic cancer cell radiation survival and prenyltransferase inhibition: Te role of K-Ras Cancer Res 65 2005 8433 8441
    • (2005) Cancer Res , vol.65 , pp. 8433-8441
    • Brunner, T.B.1    Cengel, K.A.2    Hahn, S.M.3
  • 10
    • 0037099522 scopus 로고    scopus 로고
    • Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways
    • T.M. Grana, E.V. Rusyn, and H. Zhou Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways Cancer Res 62 2002 4142 4150
    • (2002) Cancer Res , vol.62 , pp. 4142-4150
    • Grana, T.M.1    Rusyn, E.V.2    Zhou, H.3
  • 11
    • 0345275865 scopus 로고    scopus 로고
    • Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance
    • T.M. Grana, C.I. Sartor, and A.D. Cox Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance Cancer Res 63 2003 7807 7814
    • (2003) Cancer Res , vol.63 , pp. 7807-7814
    • Grana, T.M.1    Sartor, C.I.2    Cox, A.D.3
  • 12
    • 34247245135 scopus 로고    scopus 로고
    • Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells
    • K.A. Cengel, K.R. Voong, and S. Chandrasekaran Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells Neoplasia 9 2007 341 348
    • (2007) Neoplasia , vol.9 , pp. 341-348
    • Cengel, K.A.1    Voong, K.R.2    Chandrasekaran, S.3
  • 13
    • 28444475478 scopus 로고    scopus 로고
    • Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    • M. Toulany, K. Dittmann, and M. Krüger Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway Radiother Oncol 76 2005 143 150
    • (2005) Radiother Oncol , vol.76 , pp. 143-150
    • Toulany, M.1    Dittmann, K.2    Krüger, M.3
  • 14
    • 0030022174 scopus 로고    scopus 로고
    • Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation
    • T. Urano, R. Emkey, and L.A. Feig Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation EMBO J 15 1996 810 816
    • (1996) EMBO J , vol.15 , pp. 810-816
    • Urano, T.1    Emkey, R.2    Feig, L.A.3
  • 15
    • 0029950722 scopus 로고    scopus 로고
    • A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
    • M.A. White, T. Vale, and J.H. Camonis A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation J Biol Chem 271 1996 16439 16442
    • (1996) J Biol Chem , vol.271 , pp. 16439-16442
    • White, M.A.1    Vale, T.2    Camonis, J.H.3
  • 17
    • 38849147752 scopus 로고    scopus 로고
    • Ral GTPases and cancer: Linchpin support of the tumorigenic platform
    • B.O. Bodemann, and M.A. White Ral GTPases and cancer: Linchpin support of the tumorigenic platform Nat Rev Cancer 8 2008 133 140
    • (2008) Nat Rev Cancer , vol.8 , pp. 133-140
    • Bodemann, B.O.1    White, M.A.2
  • 18
    • 0042353628 scopus 로고    scopus 로고
    • RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival
    • Y. Chien, and M.A. White RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival EMBO Rep 4 2003 800 806
    • (2003) EMBO Rep , vol.4 , pp. 800-806
    • Chien, Y.1    White, M.A.2
  • 19
    • 20444410041 scopus 로고    scopus 로고
    • Activation of RalA is critical for Ras-induced tumorigenesis of human cells
    • K.H. Lim, A.T. Baines, and J.J. Fiordalisi Activation of RalA is critical for Ras-induced tumorigenesis of human cells Cancer Cell 7 2005 533 545
    • (2005) Cancer Cell , vol.7 , pp. 533-545
    • Lim, K.H.1    Baines, A.T.2    Fiordalisi, J.J.3
  • 20
    • 33845448647 scopus 로고    scopus 로고
    • Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells
    • K.H. Lim, K. O'Hayer, and S.J. Adam Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells Curr Biol 16 2006 2385 2394
    • (2006) Curr Biol , vol.16 , pp. 2385-2394
    • Lim, K.H.1    O'Hayer, K.2    Adam, S.J.3
  • 21
    • 23844472876 scopus 로고    scopus 로고
    • RalA and RalB: Antagonistic relatives in cancer cell migration
    • G. Oxford, C.R. Owens, and B.J. Titus RalA and RalB: Antagonistic relatives in cancer cell migration Cancer Res 65 2005 7111 7120
    • (2005) Cancer Res , vol.65 , pp. 7111-7120
    • Oxford, G.1    Owens, C.R.2    Titus, B.J.3
  • 22
    • 0037102561 scopus 로고    scopus 로고
    • Distinct requirements for Ras oncogenesis in human versus mouse cells
    • N.M. Hamad, J.H. Elconin, and A.E. Karnoub Distinct requirements for Ras oncogenesis in human versus mouse cells Genes Dev 16 2002 2045 2057
    • (2002) Genes Dev , vol.16 , pp. 2045-2057
    • Hamad, N.M.1    Elconin, J.H.2    Karnoub, A.E.3
  • 23
    • 0029089074 scopus 로고
    • Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
    • V. Jullien-Flores, O. Dorseuil, and F. Romero Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity J Biol Chem 270 1995 22473 22477
    • (1995) J Biol Chem , vol.270 , pp. 22473-22477
    • Jullien-Flores, V.1    Dorseuil, O.2    Romero, F.3
  • 24
    • 21344454610 scopus 로고    scopus 로고
    • RLIP76 is a major determinant of radiation sensitivity
    • S. Awasthi, S.S. Singhal, and S. Yadav RLIP76 is a major determinant of radiation sensitivity Cancer Res 65 2005 6022 6028
    • (2005) Cancer Res , vol.65 , pp. 6022-6028
    • Awasthi, S.1    Singhal, S.S.2    Yadav, S.3
  • 25
    • 20444393402 scopus 로고    scopus 로고
    • Ral GTPases: Corrupting the exocyst in cancer cells
    • J.H. Camonis, and M.A. White Ral GTPases: Corrupting the exocyst in cancer cells Trends Cell Biol 15 2005 327 332
    • (2005) Trends Cell Biol , vol.15 , pp. 327-332
    • Camonis, J.H.1    White, M.A.2
  • 26
  • 27
    • 30644463689 scopus 로고    scopus 로고
    • RalB mobilizes the exocyst to drive cell migration
    • C. Rossé, A. Hatzoglou, and M.C. Parrini RalB mobilizes the exocyst to drive cell migration Mol Cell Biol 26 2006 727 734
    • (2006) Mol Cell Biol , vol.26 , pp. 727-734
    • Rossé, C.1    Hatzoglou, A.2    Parrini, M.C.3
  • 28
    • 26244439675 scopus 로고    scopus 로고
    • Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission
    • A. Gromley, C. Yeaman, and J. Rosa Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission Cell 123 2005 75 87
    • (2005) Cell , vol.123 , pp. 75-87
    • Gromley, A.1    Yeaman, C.2    Rosa, J.3
  • 29
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • W.P. Roos, and B. Kaina DNA damage-induced cell death by apoptosis Trends Mol Med 12 2006 440 450
    • (2006) Trends Mol Med , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 30
    • 31444445458 scopus 로고    scopus 로고
    • A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery
    • M.C. Keogh, J.A. Kim, and M. Downey A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery Nature 439 2006 497 501
    • (2006) Nature , vol.439 , pp. 497-501
    • Keogh, M.C.1    Kim, J.A.2    Downey, M.3
  • 31
    • 45549104749 scopus 로고    scopus 로고
    • Characterization of RalB-Sec5-TBK1 function in human oncogenesis
    • Y. Chien, and M.A. White Characterization of RalB-Sec5-TBK1 function in human oncogenesis Meth Enzymol 438 2008 321 329
    • (2008) Meth Enzymol , vol.438 , pp. 321-329
    • Chien, Y.1    White, M.A.2
  • 32
    • 22144492563 scopus 로고    scopus 로고
    • Molecular targets for altering radiosensitivity: Lessons from Ras as a pre-clinical and clinical model
    • K.A. Cengel, and W.G. McKenna Molecular targets for altering radiosensitivity: Lessons from Ras as a pre-clinical and clinical model Crit Rev Oncol Hematol 55 2005 103 116
    • (2005) Crit Rev Oncol Hematol , vol.55 , pp. 103-116
    • Cengel, K.A.1    McKenna, W.G.2
  • 33
    • 0030052074 scopus 로고    scopus 로고
    • Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: Influence of H-ras on the G2 delay
    • W.G. McKenna, E.J. Bernhard, and D.A. Markiewicz Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: influence of H-ras on the G2 delay Oncogene 12 1996 237 245
    • (1996) Oncogene , vol.12 , pp. 237-245
    • McKenna, W.G.1    Bernhard, E.J.2    Markiewicz, D.A.3
  • 34
    • 0026129706 scopus 로고
    • Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc
    • W.G. McKenna, G. Iliakis, and M.C. Weiss Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc Radiat Res 125 1991 283 287
    • (1991) Radiat Res , vol.125 , pp. 283-287
    • McKenna, W.G.1    Iliakis, G.2    Weiss, M.C.3
  • 35
    • 0037205398 scopus 로고    scopus 로고
    • Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species
    • H.J. Cho, H.G. Jeong, and J.S. Lee Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species J Biol Chem 277 2002 19358 19366
    • (2002) J Biol Chem , vol.277 , pp. 19358-19366
    • Cho, H.J.1    Jeong, H.G.2    Lee, J.S.3
  • 36
    • 23044508571 scopus 로고    scopus 로고
    • Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells
    • I. Chang, C. Youn, and H. Kim Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells Cancer Res 65 2005 6811 6819
    • (2005) Cancer Res , vol.65 , pp. 6811-6819
    • Chang, I.1    Youn, C.2    Kim, H.3
  • 37
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • K.K. Khanna, and S.P. Jackson DNA double-strand breaks: signaling, repair and the cancer connection Nat Genet 27 2001 247 254
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 38
    • 0033587015 scopus 로고    scopus 로고
    • P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints
    • L.S. Agapova, A.V. Ivanov, and A.A. Sablina P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints Oncogene 18 1999 3135 3142
    • (1999) Oncogene , vol.18 , pp. 3135-3142
    • Agapova, L.S.1    Ivanov, A.V.2    Sablina, A.A.3
  • 39
    • 4344692001 scopus 로고    scopus 로고
    • Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint
    • L.S. Agapova, J.L. Volodina, and P.M. Chumakov Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint J Biol Chem 279 2004 36382 36389
    • (2004) J Biol Chem , vol.279 , pp. 36382-36389
    • Agapova, L.S.1    Volodina, J.L.2    Chumakov, P.M.3
  • 40
    • 0033781565 scopus 로고    scopus 로고
    • Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB
    • D.O. Henry, S.A. Moskalenko, and K.J. Kaur Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB Mol Cell Biol 20 2000 8084 8092
    • (2000) Mol Cell Biol , vol.20 , pp. 8084-8092
    • Henry, D.O.1    Moskalenko, S.A.2    Kaur, K.J.3
  • 41
    • 2342635919 scopus 로고    scopus 로고
    • Cell death by mitotic catastrophe: A molecular definition
    • M. Castedo, J.-L. Perfettini, and T. Roumier Cell death by mitotic catastrophe: a molecular definition Oncogene 23 2004 2825 2837
    • (2004) Oncogene , vol.23 , pp. 2825-2837
    • Castedo, M.1    Perfettini, J.-L.2    Roumier, T.3
  • 42
    • 33749165933 scopus 로고    scopus 로고
    • RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival
    • Y. Chien, S. Kim, and R. Bumeister RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival Cell 127 2006 157 170
    • (2006) Cell , vol.127 , pp. 157-170
    • Chien, Y.1    Kim, S.2    Bumeister, R.3
  • 43
    • 0030296550 scopus 로고    scopus 로고
    • Evidence for a Ras/Ral signaling cascade
    • L.A. Feig, T. Urano, and S. Cantor Evidence for a Ras/Ral signaling cascade Trends Biochem Sci 21 1996 438 441
    • (1996) Trends Biochem Sci , vol.21 , pp. 438-441
    • Feig, L.A.1    Urano, T.2    Cantor, S.3
  • 44
    • 0029001797 scopus 로고
    • Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases
    • S.B. Cantor, T. Urano, and L.A. Feig Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases Mol Cell Biol 15 1995 4578 4584
    • (1995) Mol Cell Biol , vol.15 , pp. 4578-4584
    • Cantor, S.B.1    Urano, T.2    Feig, L.A.3
  • 45
    • 0347647745 scopus 로고    scopus 로고
    • Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76)
    • S. Awasthi, R. Sharma, and Y. Yang Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76) Acta Biochim Pol 49 2002 855 867
    • (2002) Acta Biochim Pol , vol.49 , pp. 855-867
    • Awasthi, S.1    Sharma, R.2    Yang, Y.3
  • 46
    • 53049101724 scopus 로고    scopus 로고
    • Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76
    • S.S. Singhal, S. Yadav, and J. Singhal Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76 FEBS Lett 582 2008 3408 3414
    • (2008) FEBS Lett , vol.582 , pp. 3408-3414
    • Singhal, S.S.1    Yadav, S.2    Singhal, J.3
  • 47
    • 0346154744 scopus 로고    scopus 로고
    • Ral GTPases regulate exocyst assembly through dual subunit interactions
    • S. Moskalenko, C. Tong, and C. Rosse Ral GTPases regulate exocyst assembly through dual subunit interactions J Biol Chem 278 2003 51743 51748
    • (2003) J Biol Chem , vol.278 , pp. 51743-51748
    • Moskalenko, S.1    Tong, C.2    Rosse, C.3
  • 48
    • 51949085937 scopus 로고    scopus 로고
    • Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs
    • I. Cascone, R. Selimoglu, and C. Ozdemir Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs EMBO J 2008
    • (2008) EMBO J
    • Cascone, I.1    Selimoglu, R.2    Ozdemir, C.3
  • 49
    • 0028818914 scopus 로고
    • Involvement of Ral GTPase in v-Src-induced phospholipase D activation
    • H. Jiang, J.Q. Luo, and T. Urano Involvement of Ral GTPase in v-Src-induced phospholipase D activation Nature 378 1995 409 412
    • (1995) Nature , vol.378 , pp. 409-412
    • Jiang, H.1    Luo, J.Q.2    Urano, T.3
  • 50
    • 13244260780 scopus 로고    scopus 로고
    • RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity
    • P. Frankel, A. Aronheim, and E. Kavanagh RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity EMBO J 24 2005 54 62
    • (2005) EMBO J , vol.24 , pp. 54-62
    • Frankel, P.1    Aronheim, A.2    Kavanagh, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.