Metabolic syndrome in childhood - Causes and effects

Endocrine Development

Volumn 19, Issue , 2010, Pages 62-72

  Weiss, Ram ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AFRICAN AMERICAN; ANTHROPOMETRIC PARAMETERS; ARTERIAL STIFFNESS; BIOCHEMISTRY; BODY MASS; CARDIOVASCULAR RISK; CAUCASIAN; CELL STRESS; CHILDHOOD DISEASE; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID ANALYSIS; LIPID STORAGE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SCORING SYSTEM; SIGNAL TRANSDUCTION; SMALL FOR DATE INFANT; SODIUM RETENTION; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; UNITED STATES; WAIST CIRCUMFERENCE; CHILD; HYPERINSULINISM; PHYSIOLOGY;

CHILD; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; METABOLIC SYNDROME X; RISK FACTORS;

EID: 77955917221     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000316898     Document Type: Review

References (60)

1. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM: Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49:403-414.
2. Pyorala M, Miettinen H, Halonen P, Laakso M, Pyorala K: Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol 2000;20:538-544.
3. Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH: The metabolic syndrome. Endocr Rev 2008;29:777-822.
4. Reaven GM: Role of insulin resistance in human disease. Diabetes 1988;37:1595-1607.
5. Goran MI, Gower BA: Longitudinal study on pubertal insulin resistance. Diabetes 2001;50: 2444-2450.
6. Lutsey PL, Steffen LM, Stevens J: Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities Study. Circulation 2008;117:754-761. (Pubitemid 351640676)
7. Sakkinen PA, Wahl P, Cushman M, Lewis MR, Tracy RP: Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome. Am J Epidemiol 2000;152:897-907.
8. Hanley AJ, Festa A, D'Agostino RB Jr, Wagenknecht LE, Savage PJ, Tracy RP, Saad MF, Haffner SM: Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity. Diabetes 2004;53:1773-1781.
9. Meigs JB, D'Agostino RB Sr, Wilson PW, Cupples LA, Nathan DM, Singer DE: Risk variable clustering in the insulin resistance syndrome: the Framingham Offspring Study. Diabetes 1997; 46:1594-1600
10. Li C, Ford ES: Is there a single underlying factor for the metabolic syndrome in adolescents? A confirmatory factor analysis. Diabetes Care 2007; 30:1556-1561.
11. Goodman E, Dolan LM, Morrison JA, Daniels SR: Factor analysis of clustered cardiovascular risks in adolescence: obesity is the predominant correlate of risk among youth. Circulation 2005; 111:1970-1977.
12. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S: Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362-2374.
13. Mertens I, Van Gaal LF: Obesity, haemostasis and the fibrinolytic system. Obes Rev 2002;3:85-101.
14. Yudkin JS: Inflammation, obesity, and the metabolic syndrome. Horm Metab Res 2007;39:707-709.
15. Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S: The 'obese insulin-sensitive' adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab 2005; 90:3731-3737.
16. Kwiterovich PO Jr: Recognition and management of dyslipidemia in children and adolescents. J Clin Endocrinol Metab 2008;93:4200-4209.
17. Matsuzawa Y, Funahashi T, Nakamura T: Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 2000;893: 146-154.
18. Wajchenberg BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697-738.
19. Cruz ML, Bergman RN, Goran MI: Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes. Diabetes Care 2002;25:1631-1636.
20. Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA: Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 2003;88: 2534-2540.
21. Taksali SE, Caprio S, Dziura J, Dufour S, CaliAM, Goodman TR, Papademetris X, Burgert TS, Pierpont BM, Savoye M, Shaw M, Seyal AA, Weiss R: High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 2008;57:367-371.
22. Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S: Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet 2003;362: 951-957.
23. Shulman GI: Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-176.
24. Stumvoll M, Tataranni PA, Stefan N, Vozarova B, Bogardus C: Glucose allostasis. Diabetes 2003;52: 903-909.
25. Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S: Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth. Diabetes Care 2007;30: 1845-1850.
26. Facchini F, Chen YD, Hollenbeck CB, Reaven GM: Relationship between resistance to insulinmediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 1991;266:3008-3011.
27. Dunaif A: Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997;18:774-800.
28. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 1991;87:2246-2252.
29. Van Gaal LF, Mertens IL, De Block CE: Mechanisms linking obesity with cardiovascular disease. Nature 2006;444:875-880.
30. Druet C, Dabbas M, Baltakse V, Payen C, Jouret B, Baud C, Chevenne D, Ricour C, Tauber M, Polak M, Alberti C, Levy-Marchal C: Insulin resistance and the metabolic syndrome in obese French children. Clin Endocrinol 2006;64:672-678.
31. De Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N: Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation 2004;110:2494-2497.
32. Lee S, Bacha F, Gungor N, Arslanian S: Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J Pediatr 2008;152:177-184.
33. Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S: The metabolic syndrome in children and adolescents. International Diabetes Federation Task Force on Epidemiology and Prevention of Diabetes. Lancet 2007;369:2059-2061.
34. Kahn R, Buse J, Ferrannini E, Stern M; American Diabetes Association; European Association for the Study of Diabetes: The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005;28:2289-2304.
35. Brambilla P, Lissau I, Flodmark CE, Moreno LA, Widhalm K, Wabitsch M, Pietrobelli A: Metabolic risk-factor clustering estimation in children: to draw a line across pediatric metabolic syndrome. Int J Obes (Lond) 2007;31:591-600.
36. Baker JL, Olsen LW, Søensen TI: Childhood body mass index and the risk of coronary heart disease in adulthood. N Engl J Med 2007;357: 2329-2337.
37. Freedman DS, Mei Z, Srinivasan SR, Berenson GS, Dietz WH: Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr 2007;150:12-17.
38. Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, Kochba I, Rudich A, Israeli Diabetes Research Group: Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 2005;353:1454-1462.
39. Tirosh A, Shai I, Bitzur R, Kochba I, Tekes- Manova D, Israeli E, Shochat T, Rudich A: Changes in triglyceride levels over time and risk of type 2 diabetes in young men. Diabetes Care 2008;31:2032-2037.
40. Tirosh A, Rudich A, Shochat T, Tekes-Manova D, Israeli E, Henkin Y, Kochba I, Shai I: Changes in triglyceride levels and risk for coronary heart disease in young men. Ann Intern Med 2007;147:377-385.
41. Dabelea D, Pettitt DJ, Jones KL, Arslanian SA: T2DM mellitus in minority children and adolescents: an emerging problem. Endocrinol Metab Clin North Am 1999;28:709-729.
42. Haines L, Wan KC, Lynn R, Barrett TG, Shield JP: Rising incidence of type 2 diabetes in children in the UK. Diabetes Care 2007;30:1097-1101.
43. Arslanian SA: Metabolic differences between Caucasian and African-American children and the relationship to T2DM mellitus. J Pediatr Endocrinol Metab 2002;15(suppl 1):509-517.
44. Arslanian SA, Saad R, Lewy V, Danadian K, Janosky J: Hyperinsulinemia in African-American children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes 2002;51:3014-3019.
45. Deurenberg-Yap M, Chew SK, Deurenberg P: Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians. Obes Rev 2002;3:209-215.
46. Liska D, Dufour S, Zern TL, Taksali S, CaliAM, Dziura J, Shulman GI, Pierpont BM, Caprio S: Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents. PLoS ONE 2007;2:e569.
47. Misra A, Wasir JS, Vikram NK: Waist circumference criteria for the diagnosis of abdominal obesity are not applicable uniformly to all populations and ethnic groups. Nutrition 2005;21:969-976.
48. Srinivasan SR, Frerichs RR, Webber LS, Berenson GS: Serum lipoprotein profile in children from a biracial community: the Bogalusa Heart Study. Circulation 1976;54:309-318.
49. Freedman DS, Bowman BA, Otvos JD, Srinivasan SR, Berenson GS: Differences in the relation of obesity to serum triacylglycerol and VLDL subclass concentrations between black and white children: the Bogalusa Heart Study. Am J Clin Nutr 2002;75:827-833.
50. Freedman DS, Bowman BA, Otvos JD, Srinivasan SR, Berenson GS: Levels and correlates of LDL and VLDL particle sizes among children: the Bogalusa Heart Study. Atherosclerosis 2000;152: 441-449.
51. Jago R, Harrell JS, McMurray RG, Edelstein S, El Ghormli L, Bassin S: Prevalence of abnormal lipid and blood pressure values among an ethnically diverse population of eighth-grade adolescents and screening implications. Pediatrics 2006;117: 2065-2073.
52. Iannuzzi A, Licenziati MR, Acampora C, Renis M, Agrusta M, Romano L, Valerio G, Panico S, Trevisan M: Carotid artery stiffness in obese children with the metabolic syndrome. Am J Cardiol 2006;97:528-531.
53. Lee S, Gungor N, Bacha F, Arslanian S: Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth. Diabetes Care 2007;30: 2091-2097.
54. Mimoun E, Aggoun Y, Pousset M, Dubern B, BougĺD, Girardet JP, Basdevant A, Bonnet D, Tounian PJ: Association of arterial stiffness and endothelial dysfunction with metabolic syndrome in obese children. Pediatrics 2008;153:65-70.
55. Berenson GS, Srinivasan SR, Bao W, Newman WP III, Tracy RE, Wattigney WA: Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults: the Bogalusa Heart Study. N Engl J Med 1998;338: 1650-1656
56. Mahoney LT, Burns TL, Stanford W, Thompson BH, Witt JD, Rost CA, Lauer RM: Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol 1996;27:277-284
57. Goodman E, Daniels SR, Meigs JB, Dolan LM: Instability in the diagnosis of metabolic syndrome in adolescents. Circulation 2007;115:2316-2322.
58. Weiss R, Savoye M, Shaw M, Caprio S: Obesity dynamics and cardiovascular risk factor stability in obese adolescents. Pediatr Diabetes 2009;10: 360-367.
59. Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S: Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA 2007;297:2697-2704.
60. Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM: Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics 2009;123: 214-222.