Factor analysis of clustered cardiovascular risks in adolescence: Obesity is the predominant correlate of risk among youth

Circulation

Volumn 111, Issue 15, 2005, Pages 1970-1977

  Goodman, Elizabeth ^a   Dolan, Lawrence M ^b   Morrison, John A ^b   Daniels, Stephen R ^b  

^a BRANDEIS UNIVERSITY   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Metabolic syndrome X; Obesity; Pediatrics; Risk factors

Indexed keywords

CARBOHYDRATE; CHOLESTEROL; FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ANALYTIC METHOD; ARTICLE; BLOOD PRESSURE; BODY MASS; CARBOHYDRATE METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; FACTORIAL ANALYSIS; FEMALE; HIGH RISK POPULATION; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; MALE; MEASUREMENT; NORMAL HUMAN; OBESITY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCHOOL; SCORING SYSTEM; SYSTOLIC BLOOD PRESSURE; UNITED STATES; WAIST CIRCUMFERENCE;

ADOLESCENT; BODY WEIGHTS AND MEASURES; CARDIOVASCULAR DISEASES; CLUSTER ANALYSIS; FACTOR ANALYSIS, STATISTICAL; FEMALE; HUMANS; LIPIDS; MALE; METABOLIC SYNDROME X; OBESITY; RISK FACTORS;

EID: 17644387796     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000161957.34198.2B     Document Type: Article

References (36)

1. Berenson GS, Wattigney WA, Bao W, Srinivasan SR, Radhakrishnamurthy B. Rationale to study the early natural history of heart disease: the Bogalusa Heart Study. Am J Med Sci. 1995;310(suppl 1):S22-S28.
2. Chen W, Bao W, Begum S, Elkasabany A, Srinivasan SR, Berenson GS. Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study. Diabetes. 2000;49:1042-1048.
3. Berenson GS, Srinivasan SR, Bao W, Newman WP III, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults: the Bogalusa Heart Study. N Engl J Med. 1998;338:1650-1656.
4. Mahoney LT, Burns TL, Stanford W, Thompson BH, Witt JD, Rost CA, Lauer RM. Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol. 1996;27:277-284.
5. Clarke WR, Woolson RF, Lauer RM. Changes in ponderosity and blood pressure in childhood: the Muscatine Study. Am J Epidemiol. 1986;124:195-206.
6. Frontini MG, Srinivasan SR, Berenson GS. Longitudinal changes in risk variables underlying metabolic syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. Int J Obes Relat Metab Disord. 2003;27: 1398-1404.
7. Chen W, Srinivasan SR, Elkasabany A, Berenson GS. Cardiovascular risk factors clustering features of insulin resistance syndrome (syndrome X) in a biracial (black-white) population of children, adolescents, and young adults: the Bogalusa Heart Study. Am J Epidemiol. 1999;150:667-674.
8. Gray RS, Fabsitz RR, Cowan LD, Lee ET, Howard BV, Savage PJ. Risk factor clustering in the insulin resistance syndrome: the Strong Heart Study. Am J Epidemiol. 1998;148:869-878.
9. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607.
10. Steinberger J. Diagnosis of the metabolic syndrome in children. Curr Opin Lipidol. 2003;14:555-559.
11. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med. 2003;157:821-827.
12. Goodman E, Daniels SR, Morrison JA, Huang B, Dolan LM. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr. 2004;145:445-451.
13. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 2002;51:204-209.
14. Srinivasan SR, Myers L, Berenson GS. Rate of change in adiposity and its relationship to concomitant changes in cardiovascular risk variables among biracial (black-white) children and young adults: the Bogalusa Heart Study. Metabolism. 2001;50:299-305.
15. Srinivasan SR, Bao W, Wattigney WA, Berenson GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism. 1996;45:235-240.
16. Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics. 2001;108:712-718.
17. Meigs JB, D'Agostino RB Sr, Wilson PW, Cupples LA, Nathan DM, Singer DE. Risk variable clustering in the insulin resistance syndrome: the Framingham Offspring Study. Diabetes. 1997;46:1594-600.
18. Leyva F, Godsland IF, Worthington M, Walton C, Stevenson JC. Factors of the metabolic syndrome: baseline interrelationships in the first follow-up cohort of the HDDRISC Study (HDDRISC-1): Heart Disease and Diabetes Risk Indicators in a Screened Cohort. Arterioscler Thromb Vasc Biol. 1998;18:208-214.
19. Edwards KL, Burchfiel CM, Sharp DS, Curb JD, Rodriguez BL, Fujimoto WY, LaCroix AZ, Vitiello MV, Austin MA. Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men. Am J Epidemiol. 1998;147:441-447.
20. Lempiainen P, Mykkanen L, Pyorala K, Laakso M, Kuusisto J. Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation. 1999;100:123-128.
21. Sakkinen PA, Wahl P, Cushman M, Lewis MR, Tracy RP. Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome. Am J Epidemiol. 2000;152:897-907.
22. Pyorala M, Miettinen H, Halonen P, Laakso M, Pyorala K. Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol. 2000;20:538-544.
23. Sudi K, Gallistl S, Payerl D, Aigner R, Moller R, Tafeit E, Borkenstein MH. Interrelationship between estimates of adiposity and body fat distribution with metabolic and hemostatic parameters in obese children. Metabolism. 2001;50:681-687.
24. Anderson PJ, Critchley JA, Chan JC, Cockram CS, Lee ZS, Thomas GN, Tomlinson B. Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality. Int J Obes Relat Metab Disord. 2001;25:1782-1788.
25. Lindblad U, Langer RD, Wingard DL, Thomas RG, Barrett-Connor EL. Metabolic syndrome and ischemic heart disease in elderly men and women. Am J Epidemiol. 2001;153:481-489.
26. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709-2716.
27. Hanson RL, Imperatore G, Bennett PH, Knowler WC. Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes. 2002;51:3120-3127.
28. Hanley AJ, Karter AJ, Festa A, D'Agostino R Jr, Wagenknecht LE, Savage P, Tracy RP, Saad MF, Haffner S. Factor analysis of metabolic syndrome using directly measured insulin sensitivity: the Insulin Resistance Atherosclerosis Study. Diabetes. 2002;51:2642-2647.
29. Shen B-J, Todaro JF, Niaura R, McCaffery JM, Zhang J, Spiro A, Ward KD. Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. Am J Epidemiol. 2003;157:701-711.
30. Lambert M, Paradis G, O'Loughlin J, Delvin EE, Hanley JA, Levy E. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada. Int J Obes Relat Metab Disord. 2004;28:833-841.
31. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499-511.
32. Dolan LM, Bean J, D'Alessio D, Cohen RM, Morrison JA, Goodman E, Daniels SR. The frequency of abnormal carbohydrate metabolism and diabetes in a population based screening of adolescents. J Pediatr. In press.
33. Balkau B, Charles MA, for the European Group for the Study of Insulin Resistance (EGIR). Comment on the provisional report from the WHO consultation. Diabet Med. 1999;16:442-443.
34. SPSS. SPSS Base 10.0 User's Guide. Chicago, Ill: SPSS Inc; 1999.
35. Nunnally JM, Bernstein IH. Psychometric Theory. 3rd ed. New York, NY: McGraw Hill Inc; 1994.
36. Meigs JB. Insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am J Epidemiol. 2000;152:908-911.