Biased Igλ expression in hypermutated IgD multiple myelomas does not result from receptor revision

Leukemia

Volumn 16, Issue 7, 2002, Pages 1358-1361

  Van der Burg, M ^a   Bende, R J ^b   Aarts, W M ^b   Langerak, A W ^a   Van Dongen, J J M ^a   Van Noesel, C J M ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

IgD; Multiple myeloma; Receptor revision; Stomatic mutations

Indexed keywords

IMMUNOGLOBULIN D; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; CD38 ANTIGEN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR;

ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MULTIPLE MYELOMA; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; ALLELE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GERMINAL CENTER; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

B-LYMPHOCYTES; BASE SEQUENCE; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; HUMANS; IMMUNOGLOBULIN D; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; MUTATION; RECEPTORS, ANTIGEN, B-CELL;

EID: 0035983646     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402513     Document Type: Article

References (22)

1. Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts
2. The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cm-Cd switch, and lambda light chain expression
3. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
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14. Immunoglobulin D multiple myeloma: Presenting features, response to therapy, and survival in a series of 53 cases
15. Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus
16. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
17. Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes
18. Immunoglobulin lambda isotype rearrangements in B cell malignancies
19. VH gene analysis of primary cutaneous B-cell lymphomas: Evidence for ongoing somatic hypermutation and isotype switching
20. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
21. Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells
22. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement