Human peripheral B cell development. sIgM-IgD+CD38+ hypermutated germinal center centroblasts preferentially express Igλ light chain and have undergone μ-to-δ switch

Annals of the New York Academy of Sciences

Volumn 815, Issue , 1997, Pages 193-196

  Arpin, Christophe ^a   De Bouteiller, Odette ^a   Razanajaona, Diane ^a   Brière, Francine ^a   Banchereau, Jacques ^a   Lebecque, Serge ^a   Liu, Yong Jun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

ANTIBODY PRODUCTION; B LYMPHOCYTE; CONFERENCE PAPER; GERMINAL CENTER; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION;

EID: 0030854911     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52060.x     Document Type: Conference Paper

References (6)

1. - germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 4: 603-613.
2. GILLIAM, A. C., A. SHEN, J. E. RICHARDS, F. R. BLATTNER, J. F. MUSHINSKI & P. W. TUCKER. 1984. Illegitimate recombination generates a class switch from Cμ to Cδ in an IgD-secreting plasmacytoma. Proc. Natl. Acad. Sci. U.S.A. 81: 4164-4168.
3. YASUI, H., Y. AKAHORI, M. HIRANO, K. YAMADA & Y. KUROSAWA. 1989. Class switch from μ to δ is mediated by homologous recombination between σμ and ∑μ sequences in human immunoglobulin gene loci. Eur. J. Immunol. 19: 1399-1403.
4. KLUIN, P. M., H. KAYANO, V. J. ZANI, H. C. KLUIN-NELEMANS, P. W. TUCKER, E. SATTERWHITE & M. J. S. DYER. 1995. IgD class switching; identification of a novel recombination site in neoplastic and normal B cells. Eur. J. Immunol. 25: 3504-3508.
5. VAN NIEUWKOOP, J. A. & J. RADL. 1985. Light chain types of IgD in human bone marrow and serum. Clin. Exp. Immunol. 60: 654.
6. MALISAN, F., F. BRIÈRE, J-M. BRIDON, N. HARINDRANATH, F. C. MILLS, E. E. MAX, J. BANCHEREAU & H. MARTINEZ-VALDEZ. 1996. Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes. J. Exp. Med. 183: 937-947.