Role of midbrain periaqueductal gray P2X3 receptors in electroacupuncture- mediated endogenous pain modulatory systems

Brain Research

Volumn 1330, Issue , 2010, Pages 31-44

  Xiao, Zhi ^a,b   Ou, Shan ^a,c   He, Wen Juan ^a   Zhao, Yan Dong ^a   Liu, Xiao Hong ^b   Ruan, Huai Zhen ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b ZUNYI MEDICAL UNIVERSITY   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Electroacupuncture; Endogenous pain modulatory system; Midbrain periaqueductal gray; Neuropathic pain; P2x3 receptor

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; PURINERGIC P2X3 RECEPTOR; A-317491; ADENOSINE TRIPHOSPHATE; ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE; CENTRAL NERVOUS SYSTEM AGENTS; DRUG DERIVATIVE; PHENOL DERIVATIVE; POLYCYCLIC HYDROCARBON; PURINERGIC P2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; ELECTROACUPUNCTURE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MESENCEPHALON; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; THERAPY EFFECT; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; DRUG EFFECT; GENETICS; METABOLISM; METHODOLOGY; NEURALGIA; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; UPREGULATION;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; DISEASE MODELS, ANIMAL; ELECTROACUPUNCTURE; MALE; NEURALGIA; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY; PHENOLS; POLYCYCLIC COMPOUNDS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; UP-REGULATION;

EID: 77955861834     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.03.030     Document Type: Article

References (60)

1. Basbaum, A.I., Fields, H.L., 1978. Endogenous pain control mechanisms: review and hypothesis. Ann. Neurol. 4, 451-462.
2. Basbaum, A.I., Fields, H.L., 1984. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 7, 309-338.
3. Behbehani, M.M., 1995. Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 46, 575-605.
4. Beitz, A.J., 1982. The organization of afferent projections to the midbrain periaqueductal gray of the rat. Neuroscience 7, 133-159. (Pubitemid 12212217)
5. Bennett, G.J., Xie, Y.K., 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33, 87-107.
6. Brederson, J.D., Jarvis, M.F., 2008. Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons. Curr. Opin. Investig. Drugs 9, 716-725.
7. Burnstock, G., 2004. Cotransmission. Curr. Opin. Pharmacol. 4, 47-52.
8. Burnstock, G., 2006. Historical review: ATP as a neurotransmitter. Trends Pharmacol. Sci. 27, 166-176.
9. Burnstock, G., 2009. Acupuncture: a novel hypothesis for the involvement of purinergic signalling. Med. Hypotheses 73, 470-472.
10. Carstens, E., Yokota, T., Zimmermann, M., 1979. Inhibition of spinal neuronal responses to noxious skin heating by stimulation of mesencephalic periaqueductal gray in the cat. J. Neurophysiol. 42, 558-568. (Pubitemid 9128399)
11. Chen, C.C., Akopian, A.N., Sivilotti, L., Colquhoun, D., Burnstock, G., Wood, J.N., 1995a. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428-431.
12. Chen, Z.P., Levy, A., Lightman, S.L., 1995b. Nucleotides as extracellular signalling molecules. J. Neuroendocrinol. 7, 83-96.
13. Collo, G., North, R.A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A., Buell, G., 1996. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16, 2495-2507. (Pubitemid 26124346)
14. Diaz-Hemandez, M., Gomez-Villafuertes, R., Hernando, F., Pintor, J., Miras-Portugal, M.T., 2001. Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits. Neurosci. Lett. 301, 159-162.
15. Dong, Z.Q,, Ma, F., Xie, H., Wang, Y.Q., Wu, G.C., 2006. Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide attenuates electroacupuncture analgesia on heat hyperalgesia in a rat model of neuropathic pain. Brain Res. Bull. 69, 30-36.
16. Fields, H.L., 2000. Pain modulation: expectation, opioid analgesia and virtual pain. Prog. Brain Res. 122, 245-253.
17. Fredholm, B.B., 1995. Purinoceptors in the nervous system. Pharmacol. Toxicol. 76, 228-239.
18. Fukui, M., Nakagawa, T., Minami,; M., Satoh, M., Kaneko, S., 2006. Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats. Mol. Pain. 2, 19.
19. Gebhart, G.F., Sandkuhler, J., Thalhammer, J.G., Zimmermann, M., 1984. Inhibition in spinal cord of nociceptive information by electrical stimulation and morphine microinjection at identical sites in midbrain of the cat. J. Neurophysiol. 51, 75-89. (Pubitemid 14175643)
20. Gu, J.C, MacDermott, A.B., 1997. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389, 749-753.
21. Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J., 1988. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77-88.
22. He, L.F., Dong, W.Q., 1983. Activity of opioid peptidergic system in acupuncture analgesia. Acupunct. Electrother. Res. 8, 257-266.
23. Huang, C., Li, H.T., Shi, Y.S., Han, J.S., Wan, Y., 2004. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain. Neurosci. Lett. 368, 327-331.
24. Illes, P., Ribeiro, J.A., 2004. Neuronal P2 receptors of the entral nervous system. Curr. Top. Med. Chem. 4, 831-838.
25. Jensen, T.S., Yaksh, T.L., 1984. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res. 321, 287-297.
26. Kato, M., Taguchi, K., Hagiwara, Y., Kubo, T., 1996. Effects of electrical stimulation and morphine microinjection into periaqueductal gray on 5-hydroxyindole oxidation current in spinal cord of cats. Gen. Pharmacol. 27, 1195-1201.
27. Keltner, J.R., Furst, A., Fan, C., Redfem, R., Inglis, B., Fields, H.L., 2006. Isolating the modulatory effect of expectation on pain transmission: a functional magnetic resonance imaging study. J. Neurosci. 26, 4437-4443.
28. Kim, S.H., Chung, J.M., 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50, 355-363.
29. Kim, S.K., Lee, Y., Cho, H., Koo, S., Choi, S.M., Shin, M.K., Hong, M.C., Min, B.I., Bae, H., 2009. A Parametric study on the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice. Evid. Based Complement. Alternat. Med. ISSN: 1741-4288 (Electronic). doi:10.1093/ecam/nep166.
30. Koles, L., Furst, S., illes, P., 2007. Purine ionotropic (P2X) receptors. Curr. Pharm. Des. 13, 2368-2384.
31. Li, L., Liu, H., Li, Y.Z., Xu, J.Y., Shan, B.C., Gong, D., Li, K.C., Tang, X.W., 2008. The human brain response to acupuncture on same-meridian acupoints: evidence from an fMRI study. J. Altem. Complement. Med. 14, 673-678.
32. Liu, H.R., Wang, X.M., Zhou, E.H., Shi, Y., Li, N., Yuan, L.S., Wu, H.G., 2009. Acupuncture at both ST25 and ST37 improves the pain threshold of chronic visceral hypersensitivity rats. Neurochem. Res. 34, 1914-1918.
33. Maeda, T., Hamabe, W., Gao, Y., Fukazawa, Y., Kumamoto, K., Ozaki, M., Kishioka, S., 2005. Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice. Brain Res. 1056, 191-199. (Pubitemid 41557707)
34. Man, P.L., Chen, C.H., 1972. Mechanism of acupunctural anesthesia. The two-gate control theory. Dis. Nerv. Syst. 33, 730-735.
35. Martins, M.A., Carobrez, A.P., Tonussi, C.R., 2008. Activation of dorsal periaqueductal gray by glycine produces long lasting hyponociception in rats without overt defensive behaviors. Life Sci. 83, 118-121.
36. Mason, P., 1999. Central mechanisms of pain modulation. Curr. Opin. Neurobiol. 9, 436-441.
37. Millan, M.J., 2002. Descending control of pain. Prog. Neurobiol. 66, 355-174.
38. Niu, W.X., He, G.D., Liu, H., Qin, X.Y., 2007. Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits. J. Gastroenterol. Hepatol. 22, 1683-1689.
39. Oka, T., Yoshikawa, M., Kobayashi, T., Kitamura, K., Iwao, K., Kobayashi, H., 2001. Effects of antisense oligodeoxynucleotides against opioid receptors on the receptor mRNA contents. Life Sci. 68, 2221-2225. (Pubitemid 32452376)
40. Okada, K., Murase, K., Kawakita, K., 1999a. Effects of electrical stimulation of thalamic nucleus submedius and periaqueductal gray on the visceral nociceptive responses of spinal dorsal horn neurons in the rat. Brain Res. 834, 112-121. (Pubitemid 29332015)
41. Okada, M., Kawata, Y., Murakami, T., Wada, K., Mizuno, K., Kaneko, S., 1999b. Interaction between purinoceptor subtypes on hippocampal serotonergic transmission using in vivo microdialysis. Neuropharmacology 38, 707-715. (Pubitemid 29150325)
42. Oliveira, M.C., Pelegrini-da-Silva, A., Tambeli, C.H., Parada, C.A., 2009. Peripheral mechanisms underlying the essential role of P2X3, 2/3 receptors in the development of inflammatory hyperalgesia. Pain 141, 127-134.
43. Palla, S., 2001. Meeting review: Pain in Europe: Third Congress of the European Federation of IASP Chapters. Nice, September 26-29, 2000. J. Orofac. Pain 15, 174-176.
44. Paxinos, G.W.C., 2007. The Rat Brain in Stereotaxic Coordinates. Academic Press, Amsterdam.
45. Rivlin, A.S., Tator, C.H., 1977. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47, 577-581.
46. Sator-Katzenschlager, S.M., Scharbert, G., Kozek-Langenecker, S.A., Szeles, J.C., Finster, C., Schiesser, A. W., Heinze, C., Kress, H.G., 2004. The short- and long-term benefit in chronic low back pain through adjuvant electrical versus manual auricular acupuncture. Anesth. Analg. 98, 1359-1364 table of contents.
47. Sun, S.L., Han, J.S., 1989. High and low frequency electroacupuncture analgesia are mediated by different types of opioid receptors at spinal level: a cross tolerance study. Sheng Li Xue Bao 41, 416-120.
48. Sun, Y.G., Gao, Y.J., Zhao, Z.Q., Huang, B., Yin, J., Taylor, G.A., Chen, Z.F., 2008. Involvement of P311 in the affective, but not in the sensory component of pain. Mol. Pain 4, 23.
49. Tanck, E.N., Kroin, J.S., McCarthy, R.J., Penn, R.D., Ivankovich, A.D., 1992. Effects of age and size on development of allodynia in a chronic pain model produced by sciatic nerve ligation in rats. Pain 51, 313-316.
50. Tavares, I., Lima, D., 2007. From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system. J. Anat. 211, 261-268. (Pubitemid 47278557)
51. Tsuda, M., Ueno, S., Inoue, K., 1999. In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha, beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system. Br. J. Pharmacol. 127, 449-456.
52. Van Nassauw, L., Bogers, J., Van Marck, E., Timmermans, J.P., 2001. Role of reactive nitrogen species in neuronal cell damage during intestinal schistosomiasis. Cell Tissue Res. 303, 329-336. (Pubitemid 32250104)
53. Vulchanova, L., Riedl, M.S., Shuster, S.J., Stone, L.S., Hargreaves, K.M., Buell, G., Surprenant, A., North, R.A., Elde, R., 1998. P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur. J. NeuroSci. 10, 3470-3478.
54. White, P., 2006. A background to acupuncture and its use in chronic painful musculoskeletal conditions. J. R. Soc Promot. Health 126, 219-227.
55. Wismer, C.T., Faltynek, C.R., Jarvis, M.F., McGaraughty, S., 2003. Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat. Brain Res. 965, 187-193. (Pubitemid 36183702)
56. Worthington, R.A., Arumugam, T.V., Hansen, M.A., Balear, V.J., Barden, J.A., 1999. Identification and localisation of ATP P2X receptors in rat midbrain. Electrophoresis 20, 2077-2080.
57. Xing, G., Liu, F., Wan, Y., Yao, L., Han, J., 2003. Electroacupuncture of 2 Hz induces long-term depression of synaptic transmission in the spinal dorsal horn in rats with neuropathic pain. Beijing Da Xue Xue Bao 35, 453-157.
58. Xing, J., Lu, J., Li, J., 2008. Purinergic P2X receptors presynaptically increase glutamatergic synaptic transmission in dorsolateral periaqueductal gray. Brain Res. 1208, 46-55.
59. Zhao, Z.Q., 2008. Neural mechanism underlying acupuncture analgesia. Prog. Neurobiol. 85, 355-375.
60. Zimmermann, M., 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109-110.