Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells

Archives of Pharmacal Research

Volumn 24, Issue 4, 2001, Pages 349-354

  Kim, Mi Sung ^a   Kang, Hye Jung ^a   Moon, Aree ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Apoptosis; Bax; Bcl 2; Curcumin; Invasion; ROS

Indexed keywords

ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CURCUMIN; DNA FRAGMENT; REACTIVE OXYGEN METABOLITE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

APOPTOSIS; ARTICLE; BREAST; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; ONCOGENE RAS; OXIDATION REDUCTION REACTION; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST; CASPASE 3; CASPASES; CURCUMIN; DNA FRAGMENTATION; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENES, BCL-2; GENES, RAS; HUMANS; IMMUNOBLOTTING; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0035434001     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975105     Document Type: Article

References (32)

1. Alnemri, E. S., Mammalian cell death protease: a family of highly conserved aspartate specific cytosine proteases. J. Cell Biochem., 64, 33-42 (1997).
2. Anjum, R. and Khar, A., Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2: presence of Bcl-2 dependent and independent pathways. FEBS Lett., 499, 166-70 (2001).
3. Bass, D. A., Parce, J. W., Dechatelet, L. R., Szejda, p., Seeds, M. C., and Thomas, M., Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol., 130 (4), 1910-7 (1983).
4. Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I. C., Tekle, E., Chock, P. B., and Rhee, S. C., Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J. Biol. Chem., 272(1), 217-21 (1997).
5. Bernhard, E. J., Gruber, S. B., and Muschel, R. J., Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/ collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci., 91, 4293-7 (1994).
6. Bhaumik, S., Anjum, R., Rangaraj, N., Pardhasaradhi, B. V, and Khar, A., Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett., 456, 311-4 (1999).
7. Chun, K. -S., Shon, Y., Kim, H. -S., Kim, O. H., Park, K.-K., Lee, J. -M., Lee, J., Lee, J. -Y, Moon, A., Lee, S. S., and Surh, Y. -J., Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. Mutat. Res., 428, 49-57 (1999).
8. Cooper, J. D., Michaelidis, T. M., Tzimagiorgis, G. Z., Sendtner, M., Meyer, M., and Thoenen, H., Cholinergic neuron-specific overexpression of Bax in ChAT Bax transgenic mice. Soc. Neurosci. Abstr., 22, 570 (1996).
9. Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E., Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate, 47, 293-303 (2001).
10. Ferguson, L. R., Antimutagens as cancer chemopreventive agents in the diet. Mut. Res., 307, 395-410 (1994).
11. Fukamachi, Y., Karasaki, Y., Sugiura, T., Itoh, H., Abe, T., Yamamura, K. and Higashi, K., Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase of the Bcl-2/Bax ratio. Biochem. Biophys. Res. Commun., 246, 364-9 (1998).
12. Huang, M. -T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H., Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res., 51, 813-9 (1991).
13. Joe, B. and Lokesh, B. R., Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta, 1224, 255-63 (1994).
14. Jung, M. -Y., Kang, H. -J., and Moon, A., Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett., 165, 139-145 (2001a).
15. Jung, M. -Y., Kwon, S. -K., and Moon, A., Chemopreventive allylthiopyridazine derivatives induce apoptosis in SK-Hep-1 hepatocarcinoma cells through a caspase-3-dependent mechanism. Eur. J. Cancer, In press (2001b).
16. Kim, M. -S., Son, M. -W., Kim, W. -B., Park, Y. I., and Moon, A., Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype. Cancer Lett., 157, 23-30 (2000).
17. Kim, M. -S. and Moon, A., Curcumin inhibits invasive phenotype of H-ras transformed human breast epithelial cells and suppresses matrix metallo-proteinase-2 activity. J. Kor. Assoc. Cancer Prevention, 4, 119-26 (1999).
18. Kim, M. -S., Won, J. -H., and Moon, A., Roles of matrix metalloproteinase-2 and -9 on the H-ras-induced invasive phenotype in human breast epithelial cells and human fibrosarcoma cells. J. Toxicol. Pub. Health, 14, 569-75 (1998).
19. Kobayashi, T., Ruan, S., Clodi, K., Kliche, K. O., Shiku, H., Andreeff, M., and Zhang, W., Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents. Oncogene, 16, 1587-91 (1998).
20. Kong, A. N., Yu, R., Chen, C., Mandlekar, S., and Primiano, T., Signal transduction events elicited by natural products: role of MARK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res., 23, 1-16 (2000).
21. Lin, L. -I., Ke, Y. -F., Ko, Y. -C., and Lin, J. -K., Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metallo-proteinse-9 secretion. Oncology, 55, 349-53 (1998).
22. Menon, L. G., Kuttan, R. and Kuttan, G., Anti-metastatic activity of curcumin and catechin. Cancer Lett., 141, 159-165 (1999).
23. Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B. B., Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs, 8, 470-81 (1997).
24. Moon, A., Kim, M. -S., Kim, T. G., Kim, S. H., Kim, H. E., Chen, Y. Q., and Kim, H. -R. C., H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: A role for MMP-2 in the H-ras induced invasive phenotype. Int. J. Cancer, 85, 176-81 (2000).
25. Moon, A., Park, S. H., and Lee, S. H., Expression of type IV collagenase genes and ras oncogene in various human tumor cell lines. J. Biochem. Mol. Biol., 29, 484-7 (1996).
26. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K., Identificaion and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376, 37-43 (1995).
27. Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-19 (1993).
28. Pereira, M. A., Grubbs, C. J., Barnes, L. H., Li, H., Olson, G. R., Eto, I., Juliana, M., Whitaker, L. M., Kelloff, G. J., Steele, V. E., and Lubet, R. A., Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[α] anthracene-induced mammary cancer in rats. Carcinogenesis, 17, 1305-11 (1996).
29. Porter, A. G. and Janike, R. U., Emerging roles of caspase-3 in apoptosis. Cell Death Differ., 6, 99-104 (1999).
30. Ramachandran, C. and You, W., Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res. Treat, 54, 269-78 (1999).
31. Wattenberg, L. W., Inhibition of carcinogenesis by minor anutrient constituents of the diet. Proc. Natl. Acad. Sci., 49, 173-83 (1990).
32. Yang, J., Liu, X., and Bhalla, K., Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science, 275, 1129-32 (1997).