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Volumn 21, Issue 10, 2010, Pages 1149-1152

A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent

Author keywords

1,3,4 Thiadiazoles; Anticonvulsant activity; Semicarbazones

Indexed keywords


EID: 77955843160     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2010.04.012     Document Type: Article
Times cited : (17)

References (13)
  • 10
    • 77955844347 scopus 로고    scopus 로고
    • Note
    • Compound 7(d): mp (°C) 218-220; yield 62%; IR (cm-1) (KBr) 3035.3 (aromatic C-H str), 1601.3 and 1502.7 (aromatic C-C str), 746.8 (C-S of 1,3,4-thiadiazole nucleus), 1644.1 (CN of 1,3,4-thiadiazole nucleus), 1684.2 (CO str of amide), 3436.6 (N-H str of amide), 1612.4 (CN group), 833.6 (para-disubstituted C-H def), 722.8 (C-Cl str), 2894.8 (Alkane C-H str), 1092.5 (CS str); 13C NMR (75MHz, DMSO-d6, TMS): δ 140.3 (C-2'), 115.8 (C-3'), 126.4 (C-4'), 154.1 (C-5'), 112.5 (C-6'), 133.6 (C-7'), 123.8 (C-8'), 121.6 (C-9'), 164.3 (C-2), 156.4 (C-5), 177.5 (NHCSNHNCO), 168.9 (NHCSNHNCO), 128.8 (C-2‴ and C-6‴), 129.2 (C-3‴ & C-5‴), 137.3 (C-4‴), 131.6 (C-1‴), 21.2 (CH3), 24.4‴ (CH2 connecting benzofuran & thiadiazole ring); 1H NMR (300MHz, DMSO-d6, TMS): δ 7.5-7.9 (m, 4H, ArH), 2.3 (s, 3H, CH3), 4.2 (s, 2H, CH2), 6.9-7.4 (m, 4H, benzofuran protons), 6.5 (s, 1H, NHCSNHCO), 9.3 (s, 1H, NHCSNHCO); ESI-MS (methanol) m/z 443.9 ([M+H]+). Compound 7(g): mp (°C) 263-265; yield 65%; IR (cm-1) (KBr) 3040.6 (aromatic C-H str), 1602.5 and 1503.8 (aromatic C-C str), 741.7 (C-S of 1,3,4-thiadiazole nucleus), 1648.1 (CN of 1,3,4-thiadiazole nucleus), 1680.2 (CO str of amide), 3439.4 (N-H str of amide), 1616.8 (CN group), 828.9 (C-H def disubstituted benzene ring), 2890.6 (alkane C-H str), 1091.7 (CS str), 3447.3 (O-H str of alcoholic group); 13C NMR (75MHz, DMSO-d6, TMS): δ 140.3 (C-2'), 115.7 (C-3'), 126.4 (C-4'), 154.1 (C-5'), 112.6 (C-6'), 133.7 (C-7'), 123.9 (C-8'), 121.6 (C-9'), 164.2 (C-2), 156.5 (C-5), 177.6 (NHCSNHNCO), 168.9 (NHCSNHNCO), 128.9 (C-2‴ and C-6‴), 115.8 (C-3‴ and C-5‴), 160.8 (C-4‴), 126.2 (C-1‴), 21.3 (CH3), 24.3 (CH2 connecting benzofuran & thiadiazole ring); 1H NMR (300MHz, DMSO-d6, TMS): δ 6.9-7.8 (m, 4H, ArH), 2.3 (s, 3H, CH3), 4.2 (s, 2H, CH2), 6.9-7.4 (m, 4H, benzofuran protons), 6.4 (s, 1H, NHCSNHCO), 9.4 (s, 1H, NHCSNHCO), 5.3 (s, 1H, ArOH); ESI-MS (methanol) m/z 425.5.([M+H]+).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.