Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles

European Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2008, Pages 1721-1729

  Jadhav, V B ^a   Kulkarni, M V ^a   Rasal, V P ^b   Biradar, S S ^b   Vinay, M D ^b  

^a KARNATAK UNIVERSITY   (India)

^b K L E S S COLLEGE OF PHARMACY   (India)

Author keywords

Analgesic activity; Anti inflammatory; Imidazo 2,1 b 1,3,4 thiadiazoles

Indexed keywords

2 (6 METHYL BENZOFURAN 3 YLMETHYL) 5 MORPHOLIN 4 YLMETHYL 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE; 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZOL[2,1 B][1,3,4]THIADAZOLE; 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE OXIME; 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBONITRILE; 5 (6 METHYL BENZOFURAN 3 YLMETHYL)[1,3,4]THIADAZOL 2 YL AMINE; 6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 5 MORPHOLIN 4 YLMETHYL 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE; 6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE OXIME; 6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBONITRILE; 6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 5 MORPHOLIN 4 YLMETHYL 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE; 6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE OXIME; 6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBONITRILE; 6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 5 MORPHOLIN 4 YLMETHYL 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE; 6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)IMIDAZO[2,1 B][1,3,4]THIADIAZOLE; 6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBALDEHYDE OXIME; 6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL)L 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBONITRILE; [2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOL 5 YL] METHANOL; [6 (4 BROMOPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOL 5 YL] METHANOL; [6 (4 CHLOROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOL 5 YL] METHANOL; [6 (4 NITROPHENYL) 2 (6 METHYL BENZOFURAN 3 YLMETHYL) 6 PHENYL IMIDAZO[2,1 B][1,3,4]THIADIAZOL 5 YL] METHANOL; ANTIINFLAMMATORY AGENT; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; X RAY DIFFRACTION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOFURANS; CROSS-LINKING REAGENTS; FEMALE; IMIDAZOLES; MALE; METHYLATION; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 47949091178     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.023     Document Type: Article

References (19)

1. Terzioglu N., and Gürsoy A. Eur. J. Med. Chem. 38 (2003) 781-786
2. Kolavi G., Hegde V., Khan I., and Gadad P. Bioorg. Med. Chem. 14 (2006) 3069-3080
3. Gadad A.K., Mahajanshetti C.S., Nimbalkar S., and Raichurkar A. Eur. J. Med. Chem. 35 (2000) 853-857
4. Andotra C.S., Langer T.C., and Kotha A. J. Indian Chem. Soc. 74 2 (1997) 125-127
5. Khazi I.A.M., Mahajanshetti C.S., Gadad A.K., Tarnalli A.D., and Sultanpur C.M. Arzneim-Forsch./Drug. Res. 46 (1996) 949-952
6. Andreani A., Leonia A., Locatelli A., Morigi R., Rambaldi M., Simon W.A., and Senn-Bilfinger J. Arzneim.-Forsch./Drug. Res. 50 (2000) 550-553
7. Andreani A., Bonazzi D., Rambaldi M., Fabbri G., and Rainsford K.D. Eur. J. Med. Chem. 17 (1982) 271-274
8. Andreani A., Rambaldi M., Mascellani G., Bossa R., and Galatulas I. Eur. J. Med. Chem. 21 (1986) 451-453
9. Andreani A., Rambaldi M., Mascellani G., and Rugarli P. Eur. J. Med. Chem. 22 (1987) 19-22
10. Andreani A., Rambaldi M., Locatelli A., and Andreani F. Collect. Czech. Chem. Commun. 56 (1991) 2436-2447
11. In: Amery W.K., Hoerig C.H., Fenichel R.I., and Chirigos M.A. (Eds). Immune Modulation Agents and Their Mechanism (1984), Marcel Dekker, New York 383-408
12. Khan I.A., Kulkarni M.V., and Sun C.M. Eur. J. Med. Chem. 40 (2005) 1168-1172 (and references cited therein)
13. Kouture K., Gouverneur V., and Mioskowski C. Bioorg. Med. Chem. Lett. 9 (1999) 3023-3026
14. Khan I.A., and Kulkarni M.V. Indian. J. Chem 38B (1999) 491-494
15. Manjunath Ghate D., Kulkarni M.V., Shobha R., and Kattimani S.Y. Eur. J. Med. Chem. 38 (2003) 297-302
16. Fall Y., Santana L., Teijeira M., and Uriarte E. Heterocycles 41 (1995) 647-650
17. Winter C.A., Risley E.A., and Nuss G.W. Proc. Soc. Exp. Biol. (N.Y.) 111 (1962) 544-547
18. Fylaktakdiou K.C., Hajipavlou-Litina D.J., Litinas K.E., and Nicolaides D.N. Curr. Pharm. Des. 10 (2004) 3813-3833
19. Turner R.A. Screening Methods in Pharmacology (1965), Academic Press, New York and London p. 223