CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones

European Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2008, Pages 1945-1954

  Jatav, Varsha ^a   Mishra, Pradeep ^a   Kashaw, Sushil ^a   Stables, J P ^b  

^a DR H S GOUR UNIVERSITY   (India)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

1,3,4 Thiadiazole; CNS depressants; MES; Styryl quinazoline 4(3H) ones; Subcutaneous pentylenetetrazole induced seizure

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; CARBAMAZEPINE; ETHOSUXIMIDE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; QUINAZOLINE DERIVATIVE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; RAT; REACTION ANALYSIS; SEIZURE; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUG DESIGN; MALE; MICE; MOTOR ACTIVITY; QUINAZOLINONES; RATS;

EID: 50949089653     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.12.003     Document Type: Article

References (22)

1. Armarego W.L.F. Adv. Heterocycl. Chem. 24 (1979) 1-62
2. Fisnerova L., Brunova B., Kocfeldova Z., Tikalova J., Maturova E., and Grimova J. Collect. Czech. Chem. Commun. 56 (1991) 2373-2381
3. Saxena S., Verma M., Saxena A.K., and Shanker K. Indian J. Pharm. Sci. 53 (1991) 48-52
4. Gravier D., Dupin J.P., Casadebaig F., Hou G., Boisseau M., and Bernard H. Pharmazie 47 (1992) 91-94
5. Yu M.J., McCowan J.R., Mason N.R., Deeter J.B., and Mendelsohn L.G. J. Med. Chem. 35 (1992) 2534-2542
6. Kurogi Y., Inoue Y., Tsutsumi K., Nakamura S., Nagao K., Yohsitsugu H., and Tsuda Y. J. Med. Chem. 39 (1996) 1433-1437
7. Boltze K.H., Dell H.D., Lehwald H., Loranz D., and Ruberg-Schweer M. Arzneim-Forsch./Drug Res. 13 (1963) 688-692
8. Wolfe J.F., Rathman T.L., Sleevi M.C., Campbell J.A., and Greenwood T.D. J. Med. Chem. 33 (1990) 161-166
9. Jain S.K., and Mishra P. Asian J. Chem. 12 (2000) 1341-1343
10. Jatav V., Kashaw S.K., and Mishra P. J. Indian Chem. Soc. 83 (2006) 1165-1170
11. Aggarwal N., and Mishra P. J. Pharm. Pharm. Sci. 7 (2004) 260-264
12. Aggarwal N., and Mishra P. J. Zhejiang Univ. 6B (2005) 617-621
13. V. Jatav, P. Mishra, S. Kashaw, J.P. Stables, Eur. J. Med. Chem., in press, doi:10.1016/j.ejmech.2007.02.004.
14. Kornet M.J., Varia T., and Beaven W. J. Heterocycl. Chem. 20 (1983) 1553-1558
15. Deshpande N., Rao Y.V., Kandlikar R.P., Rao A.D., and Reddy V.M. Indian J. Pharmacol. 18 (1986) 127-131
16. Saksena R.K., and Yasmeen R. Indian J. Chem., Sect. B 25 (1986) 438-442
17. Krall R.I., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Epilepsia 19 (1978) 409-428
18. Pester R.J., Cereghino J.J., Gladding G.D., Hessie B.J., Kupferberg H.J., Seoville B., and White B. Cleve. Clin. Q. 51 (1984) 293-305
19. Dimmock J.R., Puthucode R.N., Smith J.M., Hetherington M., Quail J.W., Pugazhenthi U., Lechler T., and Stables J.P. J. Med. Chem. 39 (1996) 3984-3997
20. Flaherty P.T., Greenwood T.D., Manheim A.L., and Wolfe J.F. J. Med. Chem. 39 (1996) 1509-1513
21. Boisser J.R., and Simon P. Arch. Int. Pharmacodyn. Ther. 158 (1965) 212-220
22. Porsolt R.D., Anton G., Blanet N., and Jalfre M. Eur. J. Pharmacol. 47 (1978) 379-391