Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 3, 1998, Pages 897-902

  Nakamura, Jiro ^a   Koh, Naoki ^a   Sakakibara, Fumihiko ^a   Hamada, Yoji ^a   Hara, Tomohiro ^a   Sasaki, Hiromitsu ^a   Chaya, Sadao ^a   Komori, Taku ^a   Nakashima, Eitaro ^a   Naruse, Keiko ^a   Kato, Koichi ^a   Takeuchi, Naohide ^a   Kasuya, Yasuhide ^a   Hotta, Nigishi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; CARNITINE; CHOLESTEROL; GLUCOSE; INSULIN; LEVACECARNINE; POLYOL; STREPTOZOCIN; TRIACYLGLYCEROL; (5 (3 THIENYL)TETRAZOL 1 YL)ACETIC ACID; (5-(3-THIENYL)TETRAZOL-1-YL)ACETIC ACID; ACETYLCARNITINE; ALDEHYDE REDUCTASE; ENZYME INHIBITOR; POLYMER; TETRAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL MODEL; ARTICLE; BLOOD FLOW; BODY WEIGHT; CARNITINE DEFICIENCY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DRUG MECHANISM; ERYTHROCYTE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MALE; MOTOR NERVE CONDUCTION; PATHOGENESIS; PRIORITY JOURNAL; RAT; RR INTERVAL; SCIATIC NERVE; THROMBOCYTE AGGREGATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HEMODYNAMICS; METABOLISM; NERVE CONDUCTION; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ACETYLCARNITINE; ALDEHYDE REDUCTASE; ANIMALS; BODY WEIGHT; CARNITINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; MALE; NEURAL CONDUCTION; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TETRAZOLES; THIOPHENES;

EID: 0032247802     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Brecher P (1983) The interaction of long-chain acyl CoA with membrane. Mol Cell Biochem 57:3-15.
2. Bremer J (1983) Carnitine-metabolism and functions. Physiol Rev 63:1420-1480.
3. Burlina AP, Sershen H, Debler EA and Lajtha A (1989) Uptake of acetyl-L-carnitine in the brain. Neurochem Res 14:489-493.
4. Cameron NE and Cotter MA (1992) Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway activity. Diabetologia 35:1011-1019.
5. Cameron NE and Cotter MA (1993) Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: Evidence from experimental studies. Diabetic Med 10:593-605.
6. Cameron NE, Cotter MA, Dines KC, Maxfield EK, Carey F and Mirrlees DJ (1994) Aldose reductase inhibition, nerve perfusion, oxygénation and function in streptozotocin-diabetic rats: Dose-response considerations and independence from a myo-inositol mechanism. Diabetologia 37:651-663.
7. Cameron NE, Cotter MA and Robertson S (1991) Essential fatty acid diet supplementation: Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats. Diabetes 40:532-539.
8. Colwell JA, Winocour PD and Halushka PV (1983) Do platelets have anything to do with diabetic microvascular disease? Diabetes 32 Suppl. 2:14-19.
9. Cotter MA, Cameron NE, Keegan A and Dines KC (1995) Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. Metabolism 44:1209-1214.
10. De Angelis C, Scarfo C, Falcinelli M, Reda E, Ramacci MT and Angelucci L (1992) Levocarnitine acetyl stimulates peripheral nerve regeneration and neuromuscular junction remodelling following sciatic nerve injury. Int J Clin Pharmacol Res 12:269-279.
11. Ditzel J and Dyerberg J (1977) Hyperlipoproteinemia, diabetes and oxygen affinity of hemoglobin. Metabolism 26:141-150.
12. Ferrari R, Ceconi C, Curello S, Pasini E and Visioli O (1989) Protective effect of propionyl-L-carnitine against ischemia and reperfusion damage. Mol Cell Biochem 88:161-168.
13. Fiske CH and Subbarow Y (1925) The colorimetric determination of phosphorus. JBiol Chem 66:375-400.
14. Greene DA and Lattimer SA (1983) Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozotocin diabetes and its correction by dietary myo-inositol supplementation. J Clin Invest 72:1058-1063.
15. Greene DA and Lattimer SA (1986) Protein kinase agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve: Implications for (Na, K)-ATPase regulation and diabetic complications. Diabetes 35:242-245.
16. Greene DA, Lattimer SA and Sima AAF (1987) Sorbitol, phosphoinositides and sodium-potassium-ATPase in the pathogenesis of diabetic complications. A Engl J Med 316:599-606.
17. Greene DA, Sima AAF, Stevens MJ, Feldman EL and Lattimer SA (1992) Complication: neuropathy, pathogenetic considerations. Diabetes Care 15:1902-1925.
18. Hara T, Nakamura J, Koh N, Sakakibara F, Hamada Y, Sasaki H, Naruse K, Nakashima E, Takeuchi N, Inukai S and Hotta N (1995) An aldose reductase inhibitor, TAT, reduces ADP-induced platelet hyperaggregation in streptozotocininduced diabetic rats with neuropathy. J Lab Clin Med 126:541-547.
19. Hotta N, Koh N, Sakakibara F, Nakamura J, Hamada Y, Kara T, Fukasawa H, Kakuta H and Sakamoto N (1996a) Effect of propionyl-L-carnitine on oscillato:-y potentials in electroretinogram in streptozotocin-diabetic rats. Eur J Pharmacol 311:199-206.
20. Hotta N, Koh N, Sakakibara F, Nakamura J, Hamada Y, Wakao T, Kara T, Mon K, Naruse K, Nakashima E and Sakamoto N (1996b) Effect of propionyl-L-carnitine on motor nerve conduction, autonomie cardiac function and nerve blood flow in rats with streptozotocin-induced diabetes: Comparison with an aldose reductase inhioitor. J Pharmacol Exp Ther 276:49-55.
21. Hotta N and Sakamoto N (1990) Aldose reductase inhibitors. In The Diabetes Annual/5, ed. by K. G. M. M. Alberti and L. P. Krall, pp. 330-361, Elsevier, Amsterdam.
22. Ido Y, McHowat J, Chang KC, Arrigoni-Martelli E, Orfalian Z, Kilo C, Corr PB ard Williamson JR (1994) Neural dysfunction and metabolic imbalances in diabetic rats: Prevention by acetyl-L-carnitine. Diabetes 43:1469-1477.
23. Inukai S, Agata M, Sato M, Naito A, Matsukawa H and Goto M (1993) Characterization of a novel aldose reductase inhibitor, TAT and its effects on streptozotocininduced diabetic neuropathy. Jpn J Pharmacol 61:221-227.
24. Khatami M, Cernadas M, Geroff AJ, Chandra P and Cohen MF (1990) Direct regulation of Na-dependent myoinositol transport by sugars in retinal pigment epithelium: Role of phorbol ester and staurosporin. Membr Biochem 9:263-277.
25. Kim J, Kyriazi H and Greene DA (1991a) Normalization of Na, K-ATPase activity in isolated membrane fraction from sciatic nerves of streptozotocin-induced diabetic rats by dietary myo-inositol supplementation in vivo or protein kinase C agonist in vitro. Diabetes 40:558-567.
26. Kim J, Rushovich EH, Thomas TP, Ueda T, Agranoff BW and Greene DA (19911)) Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myo-inositol. Diabetes 40:1545-1554.
27. Koshu K, Kamiyama K, Oka N, Endo S, Takaku A and Saito T (1982) Measurement of regional blood flow using hydrogen gas generated by electrolysis. Stroke 13:483487.
28. Lowitt S, Malone JI, Salem A, Kozak WM. and Orfalian Z (1993) Acetyl-L-carnitire corrects electroretinographic deficits in experimental diabetes. Diabetes 42:11151118.
29. Malone JI, Lowitt S, Salem AF, Miranda C, Korthals JK and Carver J (1996) The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry and function in experimental diabetes. Metabolism 45:902-907.
30. McGarry JD and Foster DW (1976) An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res 17:277-281.
31. Nakamura J, Koh N, Sakakibara F, Hamada Y, Wakao T, Kara T, Mori K, Nakashima E, Naruse K and Hotta N (1995) Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats. Eur J Pharmacol 294:207-214
32. Ohara T, Sussman KE arid Draznin B (1991) Effect of diabetes on cytosolic free Ca+ and Na + -K -ATPase in rat aorta. Diabetes 40:1560-1563.
33. Rodrigues B, Xiang H and McNeil JH (1988) Effect of L-carnitine treatment on lipii metabolism and cardiac performance in chronically diabetic rats. Diabetes 37: 1358-1364.
34. Scarfo C, Falcinelli M, Pacific! L, Bellucci A, Reda E, De Angelis C, Ramacci MT and Angelucci L (1992) Morphological and electrophysiological changes of peripheral nerve-muscle unit in the aged rat prevented by levocarnitine acetyl. Int J Cli,i Pharmacol Res 12:253-262.
35. Sima AAF, Ristic H, Merry A, Kamijo M, Lattimer SA, Stevens MJ and Greene DA (1996) Primary preventive and secondary interventionary effects of acetyl-Lcarnitine on diabetic neuropathy in the bio-breeding Worcester rat. J Clin Invest 97:1900-1907.
36. Stevens MJ, Lattimer SA, Feldman EL, Helton ED, Millington DS, Sima AAF and Greene DA (1996) Acetyl-L-carnitine deficiency as a cause of altered nerve myoinositol content, Na, K-ATPase activity and motor conduction velocity in the streptozotocin-diabetic rat. Metabolism 45:865-872.
37. Taglialatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, Jackson GR and Perez-Polo JR (1991) Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor. Dev Brain Res 59:221-230.
38. Van-Hinsbergh VW and Scheffer MA (1991) Effect of propionyl-L-carnitine on human endothelial cells. Cardiovasc Drugs Ther 5,Suppl 1:95-105.
39. Vary TC and Neely JA (1982) A mechanism of reduced myocardial carnitine levels in diabetic animals. Am J Physiol 243:H154-H158.
40. Virmani MA, Conti R, Spadoni A, Rossi S and Arrigoni-Martelli E (1994) L-Carnitini; uptake into primary rat cortical cultures: Interaction with GABA. Mol Brain Re 25:105-112.