Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord

Pain

Volumn 134, Issue 3, 2008, Pages 285-292

  Ohsawa, Masahiro ^a   Mutoh, Junpei ^a   Hisa, Hiroaki ^a  

^a KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Antinociception; Geranylgeranylation; Mevalonate; RhoA; Spinal cord; Translocation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ENZYME INHIBITOR; FORMALDEHYDE; GGTI 2133; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; GENE TRANSLOCATION; HYPERALGESIA; ISOPRENYLATION; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; SPINAL CORD; THERMAL STIMULATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MEVALONIC ACID; MICE; MICE, INBRED ICR; PAIN; PAIN THRESHOLD; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SPINAL CORD;

EID: 37849030255     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2007.04.031     Document Type: Article

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