Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17898-17903

  Matsumoto, Shingo ^a   Yasui, Hironobu ^a   Batra, Sonny ^a,b   Kinoshita, Yuichi ^c   Bernardo, Marcelino ^a,d   Munasinghe, Jeeva P ^e   Utsumi, Hideo ^c   Choudhuri, Rajani ^a   Devasahayam, Nallathamby ^a   Subramanian, Sankaran ^a   Mitchell, James B ^a   Krishna, Murali C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c KYUSHU UNIVERSITY   (Japan)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Angiogenesis; DCE MRI; Dynamic nuclear polarization; Hyperpolarized MRI; Tumor hypoxia

Indexed keywords

CONTRAST MEDIUM; OX63; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIANGIOGENIC THERAPY; ARTICLE; BLOOD FLOW; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; HYPERPOLARIZATION; HYPOXIA; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR OVERHAUSER EFFECT; OXYGEN CONCENTRATION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL PROCESSING; TUMOR;

ACTINS; ANIMALS; ANOXIA; CAPILLARY PERMEABILITY; CONTRAST MEDIA; FEMALE; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C3H; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PERICYTES;

ANIMALIA; MURINAE;

EID: 70449575832     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908447106     Document Type: Article

References (32)

1. Folkman J (2003) Fundamental concepts of the angiogenic process. Curr Mol Med 3:643-651.
2. Naumov GN, Akslen LA, Folkman J (2006) Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch. Cell Cycle 5:1779-1787. (Pubitemid 44435320)
3. Jain RK (2008) Lessons from multidisciplinary translational trials on antiangiogenic therapy of cancer. Nat Rev Cancer 8:309-316.
4. Dreher MR, et al. (2006) Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J Natl Cancer Inst 98:335-344.
5. Jain RK (2003) Molecular regulation of vessel maturation. Nat Med 9:685-693.
6. Brown JM, Giaccia AJ (1998) The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res 58:1408-1416.
7. Jain RK (2001) Normalizing tumor vasculature with antiangiogenic therapy: A new paradigm for combination therapy. Nat Med 7:987-989. (Pubitemid 32937367)
8. Kobayashi H, et al. (2004) Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation. Clin Cancer Res 10:7712-7720. (Pubitemid 39557536)
9. Matsumoto S, et al. (2008) Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice. J Clin Invest 118:1965-1973. (Pubitemid 351632398)
10. Jubb AM, Oates AJ, Holden S, Koeppen H (2006) Predicting benefit from antiangiogenic agents in malignancy. Nat Rev Cancer 6:626-635. (Pubitemid 44140860)
11. Miller JC, et al. (2005) Imaging angiogenesis: Applications and potential for drug development. J Natl Cancer Inst 97:172-187. (Pubitemid 40277367)
12. Tofts PS, et al. (1999) Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: Standardized quantities and symbols. J Magn Reson Imaging 10:223-232.
13. Su MY, Muhler A, Lao X, Nalcioglu O (1998) Tumor characterization with dynamic contrast-enhanced MRI using MR contrast agents of various molecular weights. Magn Reson Med 39:259-269. (Pubitemid 28099144)
14. Bruehlmeier M, Roelcke U, Schubiger PA, Ametamey SM (2004) Assessment of hypoxia and perfusion in human brain tumors using PET with 18F- fluoromisonidazole and 15O-H2O. J Nucl Med 45:1851-1859.
15. Ceelen W, et al. (2006) Noninvasive monitoring of radiotherapy-induced microvascular changes using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a colorectal tumor model. Int J Radiat Oncol Biol Phys 64:1188-1196. (Pubitemid 43295316)
16. Cheng HL, Wallis C, Shou Z, Farhat WA (2007) Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights. J Magn Reson Imaging 25:137-145. (Pubitemid 46095208)
17. Ardenkjaer-Larsen JH, et al. (1998) EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J Magn Reson 133:1-12.
18. Krishna MC, et al. (2002) Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration. Proc Natl Acad Sci USA 99:2216-2221.
19. Dings RP, et al. (2007) Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 13:3395-3402.
20. Kashiwagi S, et al. (2008) Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med 14:255-257. (Pubitemid 351347918)
21. Bhattacharya A, et al. (2008) Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs. Clin Cancer Res 14:3926-3932.
22. Ansiaux R, et al. (2005) Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res 11:743-750. (Pubitemid 40116903)
23. Gagel B, et al. (2007) pO polarography, contrast-enhanced color duplex sonography (CDS), [18F] fluoromisonidazole, and [18F] fluorodeoxyglucose positron emission tomography: Validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia? BMC Cancer 7:113. (Pubitemid 47272139)
24. Sorg BS, et al. (2005) Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J Biomed Opt 10:44004.
25. Lanzen J, et al. (2006) Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res 66:2219-2223. (Pubitemid 43294933)
26. Golman K, et al. (2006) Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 66:10855-10860. (Pubitemid 44876982)
27. Albers MJ, et al. (2008) Hyperpolarized 13C lactate, pyruvate, and alanine: Noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 68:8607-8615.
28. Gallagher FA, et al. (2008) Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labeled bicarbonate. Nature 453:940-943. (Pubitemid 351832568)
29. Lurie DJ, Bussell DM, Bell LH, Mallard JR (1988) Proton-electron double magnetic resonance imaging of free radical solutions. J Magn Reson 76:366-370.
30. Matsumoto S, et al. (2005) Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging. Magn Reson Med 54:213-217. (Pubitemid 40898416)
31. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7.
32. Zhou Q, Guo P, Gallo JM (2008) Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 14:1540-1549.