Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation

Journal of Physiology

Volumn 588, Issue 16, 2010, Pages 3011-3030

  Cheng, Yen May ^a   Fedida, David ^b   Kehl, Steven J ^a  

^a Department of Cellular and Physiological Sciences ^*  (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NICKEL; POTASSIUM CHANNEL KV1.5; PROTON; HYDROGEN;

ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; GENE ACTIVATION; HUMAN; HUMAN CELL; ION CONDUCTANCE; KINETICS; PH; PRIORITY JOURNAL; CELL MEMBRANE DEPOLARIZATION; DECAY TIME CONSTANT; EMBRYO CELL; INACTIVATION RATE CONSTANT; POTASSIUM CURRENT; RECOVERY TIME CONSTANT; SIGNAL TRANSDUCTION; SIMULATION; WHOLE CELL PATCH CLAMP;

CELL LINE; COMPUTER SIMULATION; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; KINETICS; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; NICKEL; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; POTASSIUM; TRANSFECTION;

EID: 77955724594     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.191544     Document Type: Article

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