Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

European Biophysics Journal

Volumn 39, Issue 9, 2010, Pages 1281-1288

  Madine, Jillian ^a   Middleton, David A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Amyloid; Cytotoxicity; Glycosaminoglycans; Inhibitor; Medin

Indexed keywords

AMYLOID; HEPARIN; PEPTIDE FRAGMENT;

ANIMAL; AORTA; ARTICLE; CATTLE; CELL LINE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; BOVINAE; DRUG EFFECTS; TOXICITY;

AMYLOID; ANIMALS; AORTA; CATTLE; CELL LINE; CELL SURVIVAL; ENDOTHELIAL CELLS; HEPARIN; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 77955661786     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-010-0581-3     Document Type: Article

References (28)

1. AT Alexandrescu 2005 Amyloid accomplices and enforcers Protein Sci 14 1 12
2. M Arrasate S Mitra ES Schweitzer MR Segal S Finkbeiner 2004 Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death Nature 431 805 810
3. RA Bodner DE Housman AG Kazantsev 2006 New directions for neurodegenerative disease therapy-using chemical compounds to boost the formation of mutant protein inclusions Cell Cycle 5 1477 1480
4. RA Bodner TF Outeiro S Altmann MM Maxwell SH Cho BT Hyman PJ McLean AB Young DE Housman AG Kazantsev 2006 Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases Proc Natl Acad Sci USA 103 4246 4251
5. M Bucciantini E Giannoni F Chiti F Baroni L Formigli J Zurdo N Taddei G Ramponi CM Dobson M Stefani 2002 Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases Nature 416 507 51111932737
6. M Calamai JR Kumita J Mifsud C Parrini M Ramazzotti G Ramponi N Taddei F Chiti CM Dobson 2006 Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes Biochemistry 45 12806 12815
7. AD Cardin HJR Weintraub 1989 Molecular modelling of protein- glycosaminoglycan interactions Arteriosclerosis 9 21 32
8. GM Castillo JA Cummings WH Yang ME Judge MJ Sheardown K Rimvall JB Hansen AD Snow 1998 Sulphate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation Diabetes 47 612 620
9. F Chiti CM Dobson 2006 Protein misfolding, functional amyloid, and human disease Annu Rev Biochem 75 333 366
10. JA Cohlberg J Li VN Uversky AL Fink 2002 Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from α-synuclein in vitro Biochemistry 41 1502 1511
11. DE Ehrnhoefer J Bieschke A Boeddrich M Herbst L Masino R Lurz S Engemann A Pastore EE Wanker 2008 EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers Nat Struct Mol Biol 15 558 566
12. B Haggqvist J Naslund K Sletten GT Westermark G Mucchiano LO Tjernberg C Nordstedt U Engstrom P Westermark 1999 Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid Proc Natl Acad Sci USA 96 8669 8674
13. R Kayed E Head JL Thompson TM McIntire SC Milton CW Cotman CG Glabe 2003 Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 486 489
14. T Konno S Oiki T Morii 2007 Synergistic action of polyanionic and non-polar cofactors in fibrillation of human islet amyloid polypeptide FEBS Letters 581 1635 1638
15. E Kvam BL Nannenga MS Wang Z Jia MR Sierks A Messer 2009 Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity PLoS ONE 4 e5727
16. A Larsson L Soderberg GT Westermark K Sletten U Engstrom LO Tjernberg J Naslund P Westermark 2007 Unwinding fibril formation of medin, the peptide of the most common form of human amyloid Biochem Biophys Res Commun 361 822 828
17. HA Lashuel D Hartley BM Petre T Walz PTJ Lansbury 2002 Amyloid pores from pathogenic mutations Nature 418 291
18. H Levine 1993 Thioflavin T interaction with synthetic Alzheimer's disease β-amyloid peptides: detection of amyloid aggregation in solution Protein Sci 2 404 410
19. J Madine A Copland LC Serpell DA Middleton 2009 Cross-β spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements Biochemistry 48 3089 3099
20. J Madine X Wang DR Brown DA Middleton 2009 Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation ChemBioChem 10 1982 1987
21. M Masuda N Suzuki S Taniguchi T Oikawa T Nonaka T Iwatsubo S-i Hisanaga M Goedert M Hasegawa 2006 Small molecule inhibitors of α-synuclein filament assembly Biochemistry 45 6085 6094
22. G Merlini P Westermark 2004 The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies J Intern Med 255 159 178
23. A Olofsson T Borowik G Grobner AE Sauer-Eriksson 2007 Negatively charged phospholipid membranes induce amyloid formation of media via an alpha-helical intermediate J Mol Biol 374 186 194
24. SW Peng GT Westermark K Sletten J Glennert P Westermark 2001 Distribution of medin-amyloid in aging and in association with arterial diseases Amyloid 8 122 123
25. S Peng A Larsson E Wassberg P Gerwins S Thelin X Fu P Westermark 2007 Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection Lab Invest 87 1195 1205
26. AD Snow R Sekiguchi D Nochlin P Fraser K Kimata A Mizutani M Arai WA Schreier DG Morgan 1994 An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain Neuron 12 219 234 (Pubitemid 24044400)
27. J van Horssen P Wesseling LPWJ van den Heuvel RMW de Waal MM Verbeek 2003 Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders Lancet Neurol 2 482 492
28. DJ Watson AD Lander DJ Selkoe 1997 Heparin-binding properties of the amyloidogenic peptides A beta and amylin-dependence on aggregation state and inhibition by Congo red J Biol Chem 272 31617 31624