Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection

Laboratory Investigation

Volumn 87, Issue 12, 2007, Pages 1195-1205

  Peng, Siwei ^a   Larsson, Annika ^a   Wassberg, Erik ^a   Gerwins, Pär ^a   Thelin, Stefan ^a   Fu, Xin ^a   Westermark, Per ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Amyloid; Aneurysm; Dissection; Lactadherin; Medin; Thoracic aorta

Indexed keywords

AMYLOID; COLLAGEN; ELASTIN; GELATINASE A; LACTADHERIN; MEDIN PEPTIDE; OLIGOMER; PEPTIDE DERIVATIVE; PROTEINASE; UNCLASSIFIED DRUG;

ADULT; AGED; AORTA DISSECTION; AORTA MEDIA; ARTERY MEDIA; ARTICLE; BLOOD VESSEL WALL; CELL CULTURE; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; MEDICAL RESEARCH; PARTICLE SIZE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; THORACIC AORTA ANEURYSM;

AGED; AMYLOID; ANEURYSM, DISSECTING; ANTIGENS, SURFACE; AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; CELL DEATH; CELLS, CULTURED; HUMANS; MATRIX METALLOPROTEINASE 2; MIDDLE AGED; MILK PROTEINS; MYOCYTES, SMOOTH MUSCLE;

EID: 36248940276     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700679     Document Type: Article

References (46)

1. Klima T, Spjut HJ, Coelho A, et al. The morphology of ascending aortic aneurysms. Hum Pathol 1983;14:810-817.
2. DeSanctis RW, Doroghazi RM, Austen WG, et al. Aortic dissection. N Engl J Med 1987;317:1060-1067.
3. Koullias GJ, Ravichandran P, Korkolis DP, et al. Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. Ann Thorac Surg 2004;78:2106-2110.
4. Taketani T, Imai Y, Morota T, et al. Altered patterns of gene expression specific to thoracic aortic aneurysms: microarray analysis of surgically resected specimens. Int Heart J 2005;46:265-277.
5. Lesauskaite V, Tanganelli P, Sassi C, et al. Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors. Hum Pathol 2001;32:1003-1011.
6. Barbour JR, Stroud RE, Lowry AS, et al. Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation. J Thorac Cardiovasc Surg 2006;132:788-795.
7. Schwartz P. Cardiovascular amyloidosis. In: Amyloidosis, Cause and Manifestation of Senile Detoriation. Charles C Thomas: Springfield, 1970, p 80-110.
8. Iwata T, Kamei T, Uchino F, et al. Pathological study on amyloidosis - relationship of amyloid deposits in the aorta to aging. Acta Pathol Jpn 1978;28:193-203.
9. Mucchiano G, Cornwell III GG, Westermark P. Senile aortic amyloid. Evidence for two distinct forms of localized deposits. Am J Pathol 1992;140:871-877.
10. Cornwell III GG, Murdoch WL, Kyle RA, et al. Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation. Am J Med 1983;75:618-623.
11. Häggqvist B, Näslund J, Sletten K, et al. Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. Proc Natl Acad Sci USA 1999;96:8669-8674.
12. Ceriani RL, Sasaki M, Sussman H, et al. Circulating human mammary epithelial antigens in breast cancer. Proc Natl Acad Sci USA 1982;79:5420-5424.
13. Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182-187.
14. Carmon L, Bobilev-Priel I, Brenner B, et al. Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/D(b)-beta2m transgenic mice. J Clin Invest 2002;110:453-462.
15. Hamosh M, Peterson JA, Henderson TR, et al. Protective function of human milk: the milk fat globule. Semin Perinatol 1999;23:242-249.
16. Shi J, Gilbert GE. Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. Blood 2003;101:2628-2636.
17. Silvestre JS, Thery C, Hamard G, et al. Lactadherin promotes VEGF-dependent neovascularization. Nat Med 2005;11:499-506.
18. Larsson A, Peng S, Persson H, et al. Lactadherin binds to elastin - a starting point for medin amyloid formation? Amyloid 2006;13:78-85.
19. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003;349:583-596.
20. Westermark P. Aspects on human amyloid forms and their fibril polypeptides. FEBSJ 2005;272:5942-5949.
21. Bucciantini M, Giannoni E, Chiti F, et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 2002;416:507-511.
22. Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003;300:486-489.
23. Thundimadathil J, Roeske RW, Jiang HY, et al. Aggregation and porin-like channel activity of a beta sheet peptide. Biochemistry 2005;44:10259-10270.
24. Schubert D, Behl C, Lesley R, et al. Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci USA 1995;92:1989-1993.
25. Behl C, Davis JB, Lesley R, et al. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994;77:817-827.
26. Sousa MM, Du Yan S, Fernandes R, et al. Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. J Neurosci 2001;21:7576-7586.
27. Revesz T, Ghiso J, Lashley T, et al. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. J Neuropathol Exp Neurol 2003;62:885-898.
28. Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124-1126.
29. Winkler DT, Bondolfi L, Herzig MC, et al. Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J Neurosci 2001;21:1619-1627.
30. Christie R, Yamada M, Moskowitz M, et al. Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. Am J Pathol 2001;158:1065-1071.
31. Puchtler H, Sweat F, Levine M. On the binding of Congo red by amyloid. J Histochem Cytochem 1962;10:355-364.
32. Westermark GT, Johnson KH, Westermark P. Staining methods for identification of amyloid in tissue. Methods Enzymol 1999;309:3-25.
33. Gustavsson Å, Engström U, Westermark P. Mechanisms of transthyretin amyloidogenesis. Antigenic mapping of transthyretin purified from plasma and amyloid fibrils and within in situ tissue localizations. Am J Pathol 1994;144:1301-1311.
34. Schägger H, von Jagow G. Tricine-sodium dodecyl sulfate- polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 1987;166:368-379.
35. Peng S, Glennert J, Westermark P. Medin-amyloid: A recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body. Amyloid 2005;12:96-102.
36. Cavaletto M, Giuffrida MG, Giunta C, et al. Multiple forms of lactadherin (breast antigen BA46) and butyrophilin are secreted into human milk as major components of milk fat globule membrane. J Dairy Res 1999;66:295-301.
37. O'Brien J, Wilson I, Orton T, et al. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 2000;267:5421-5426.
38. Peng S, Westermark GT, Näslund J, et al. Medin and medin-amyloid in ageing inflamed and non-inflamed temporal arteries. J Pathol 2002;196:91-96.
39. Deb S, Wenjun Zhang J, Gottschall PE. Beta-amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes. Brain Res 2003;970:205-213.
40. Jung SS, Zhang W, Van Nostrand WE. Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J Neurochem 2003;85:1208-1215.
41. Lee JM, Yin KJ, Hsin I, et al. Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Ann Neurol 2003;54:379-382.
42. Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 2003;26:267-298.
43. Ando Y, Nyhlin N, Suhr O, et al. Oxidative stress is found in amyloid deposits in systemic amyloidosis. Biochem Biophys Res Commun 1997;232:497-502.
44. Vitek MP, Bhattacharya K, Glendening JM, et al. Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA 1994;91:4766-4770.
45. Nyhlin N, Ando Y, Nagai R, et al. Advanced glycation end product in familial amyloidotic polyneuropathy (FAP). J Intern Med 2000;247:485-492.
46. Larsson A, Söderberg L, Westermark GT, et al. Unwinding fibril formation of medin, the peptide of the most common form of human amyloid. Biochem Biophys Res Commun 2007;361:822-828.