Amiloride derivatives modulate PS externalization in neutrophil-like PLB-985 cells

Biochemical Pharmacology

Volumn 80, Issue 7, 2010, Pages 1012-1020

  Bourge, Mickael ^a,b   Tlili, Asma ^a,b   Dupré Crochet, Sophie ^a,b   Nüße, Oliver ^a,b   Sulpice, Jean Claude ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

Author keywords

Amiloride derivative; ER stress; Ischemia reperfusion; Phagocyte; Phosphatidylserine

Indexed keywords

5 (N,N HEXAMETHYLENE)AMILORIDE; AMILORIDE DERIVATIVE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIMYCIN; CALCIUM; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; HMA; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLSERINE; PMA; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SALUBRINAL; UNCLASSIFIED DRUG; AMILORIDE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; PEPTIDE CHLOROMETHYL KETONE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL LINE; CELL PH; CONTROLLED STUDY; ELECTRIC CAPACITANCE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE; CELLS; DRUG EFFECTS; MACROPHAGE; METABOLISM; PHYSIOLOGY;

AMILORIDE; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASE 7; CELLS; HUMANS; MACROPHAGES; NADPH OXIDASE; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; TETRADECANOYLPHORBOL ACETATE;

EID: 77955659490     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.06.016     Document Type: Article

References (46)

1. Black S.C. In vivo models of myocardial ischemia and reperfusion injury: application to drug discovery and evaluation. J Pharmacol Toxicol Methods 2000, 43:153-167.
2. Linfert D., Chowdhry T., Rabb H. Lymphocytes and ischemia-reperfusion injury. Transplant Rev (Orlando) 2009, 23:1-10.
3. Suzuki Y., Matsumoto Y., Ikeda Y., Kondo K., Ohashi N., Umemura K. SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res 2002, 945:242-248.
4. Fliegel L. Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium. Expert Opin Ther Targets 2009, 13:55-68.
5. Masereel B., Pochet L., Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem 2003, 38:547-554.
6. Mentzer R.M., Bartels C., Bolli R., Boyce S., Buckberg G.D., Chaitman B., et al. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg 2008, 85:1261-1270.
7. Park K.S., Poburko D., Wollheim C.B., Demaurex N. Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. Br J Pharmacol 2009, 156:1296-1304.
8. Suzuki T., Tsukamoto I. Apoptosis induced by 5-(N,N-hexamethylene)-amiloride in regenerating liver after partial hepatectomy. Eur J Pharmacol 2004, 503:1-7.
9. Coakley R.J., Taggart C., McElvaney N.G., O'Neill S.J. Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis. Blood 2002, 100:3383-3391.
10. Rich I.N., Worthington-White D., Garden O.A., Musk P. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood 2000, 95:1427-1434.
11. Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005, 115:2656-2664.
12. Boyce M., Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 2006, 13:363-373.
13. Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006, 7:880-885.
14. Fadok V.A., Bratton D.L., Konowal A., Freed P.W., Westcott J.Y., Henson P.M. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta PGE2, and PAF. J Clin Invest 1998, 101:890-898.
15. Devaux P.F. Static and dynamic lipid asymmetry in cell membranes. Biochemistry 1991, 30:1163-1173.
16. Zwaal R.F., Schroit A.J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997, 89:1121-1132.
17. Balasubramanian K., Mirnikjoo B., Schroit A.J. Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis. J Biol Chem 2007, 282:18357-18364.
18. Lagasse E., Weissman I.L. bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 1994, 179:1047-1052.
19. Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001, 2:589-598.
20. Shi J., Gilbert G.E., Kokubo Y., Ohashi T. Role of the liver in regulating numbers of circulating neutrophils. Blood 2001, 98:1226-1230.
21. Smrz D., Draberova L., Draber P. Non-apoptotic phosphatidylserine externalization induced by engagement of glycosylphosphatidylinositol-anchored proteins. J Biol Chem 2007, 282:10487-10497.
22. Stowell S.R., Karmakar S., Stowell C.J., Dias-Baruffi M., McEver R.P., Cummings R.D. Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood 2007, 109:219-227.
23. Tyurina Y.Y., Basova L.V., Konduru N.V., Tyurin V.A., Potapovich A.I., Cai P., et al. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem 2007, 282:8498-8509.
24. van Delft M.F., Smith D.P., Lahoud M.H., Huang D.C., Adams J.M. Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases. Cell Death Differ 2010, 17:821-832.
25. Wilkie R.P., Vissers M.C., Dragunow M., Hampton M.B. A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infect Immun 2007, 75:3256-3263.
26. Sanmun D., Witasp E., Jitkaew S., Tyurina Y.Y., Kagan V.E., Ahlin A., et al. Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease. Am J Physiol Cell Physiol 2009, 297:C621-C631.
27. Fernandez-Boyanapalli R.F., Frasch S.C., McPhillips K., Vandivier R.W., Harry B.L., Riches D.W., et al. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood 2009, 113:2047-2055.
28. Pedruzzi E., Fay M., Elbim C., Gaudry M., Gougerot-Pocidalo M.A. Differentiation of PLB-985 myeloid cells into mature neutrophils, shown by degranulation of terminally differentiated compartments in response to N-formyl peptide and priming of superoxide anion production by granulocyte-macrophage colony-stimulating factor. Br J Haematol 2002, 117:719-726.
29. Ratthe C., Girard D. Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol 2008, 140:59-70.
30. Simons M.P., Leidal K.G., Nauseef W.M., Griffith T.S. TNF-related apoptosis-inducing ligand (TRAIL) is expressed throughout myeloid development, resulting in a broad distribution among neutrophil granules. J Leukoc Biol 2008, 83:621-629.
31. Zhen L., King A.A., Xiao Y., Chanock S.J., Orkin S.H., Dinauer M.C. Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proc Natl Acad Sci USA 1993, 90:9832-9836.
32. Suzuki K., Namiki H. Cytoplasmic pH-dependent spreading of polymorphonuclear leukocytes: regulation by pH of PKC subcellular distribution and F-actin assembly. Cell Biol Int 2007, 31:279-288.
33. Gottlieb R.A., Giesing H.A., Zhu J.Y., Engler R.L., Babior B.M. Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase. Proc Natl Acad Sci USA 1995, 92:5965-5968.
34. Sulpice J.C., Zachowski A., Devaux P.F., Giraud F. Requirement for phosphatidylinositol 4,5-bisphosphate in the Ca(2+)-induced phospholipid redistribution in the human erythrocyte membrane. J Biol Chem 1994, 269:6347-6354.
35. Courageot M.P., Lepine S., Hours M., Giraud F., Sulpice J.C. Involvement of sodium in early phosphatidylserine exposure and phospholipid scrambling induced by P2X7 purinoceptor activation in thymocytes. J Biol Chem 2004, 279:21815-21823.
36. 2+ entry: role of actin cytoskeleton. J Biol Chem 2001, 276:5134-5139.
37. Toullec D., Pianetti P., Coste H., Bellevergue P., Grand-Perret T., Ajakane M., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 1991, 266:15771-15781.
38. Lopez J.J., Redondo P.C., Salido G.M., Pariente J.A., Rosado J.A. N,N,N'N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress. J Thromb Haemost 2009, 7:992-999.
39. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001, 98:13681-13686.
40. Lepine S., Lakatos B., Courageot M.P., Le Stunff H., Sulpice J.C., Giraud F. Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway. J Immunol 2004, 173:3783-3790.
41. Park H.Y., Song M.G., Lee J.S., Kim J.W., Jin J.O., Park J.I., et al. Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent. J Cell Physiol 2007, 212:450-462.
42. Cobo J.M., Garcia-Canero R., Valdez J.G., Barrasso A.M., Sailer B.L., Crissman H.A. Attenuation of apoptotic DNA fragmentation by amiloride. J Cell Physiol 1998, 175:59-67.
43. Lagadic-Gossmann D., Huc L., Lecureur V. Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell Death Differ 2004, 11:953-961.
44. Matsuyama S., Llopis J., Deveraux Q.L., Tsien R.Y., Reed J.C. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000, 2:318-325.
45. Frasch S.C., Henson P.M., Kailey J.M., Richter D.A., Janes M.S., Fadok V.A., et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem 2000, 275:23065-23073.
46. Nusbaum P., Laine C., Bouaouina M., Seveau S., Cramer E.M., Masse J.M., et al. Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scrambling during neutrophil apoptosis. J Biol Chem 2005, 280:5843-5853.