메뉴 건너뛰기




Volumn 1803, Issue 10, 2010, Pages 1175-1185

Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells

Author keywords

Cell cycle; Chk1; Ganciclovir; Pancreatic cancer; Thymidine kinase

Indexed keywords

7 HYDROXYSTAUROSPORINE; COMPLEMENTARY DNA; GANCICLOVIR; THYMIDINE KINASE; ANTIVIRUS AGENT; ATM PROTEIN; ATM PROTEIN, HUMAN; ATR PROTEIN, HUMAN; CCNE1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHEK2 PROTEIN, HUMAN; CYCLIN E; DNA BINDING PROTEIN; GADD45A PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 77955652996     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.06.009     Document Type: Article
Times cited : (17)

References (34)
  • 1
    • 0037832252 scopus 로고    scopus 로고
    • Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application
    • Fillat C., Carrio M., Cascante A., Sangro B. Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application. Curr. Gene Ther. 2003, 3:13-26.
    • (2003) Curr. Gene Ther. , vol.3 , pp. 13-26
    • Fillat, C.1    Carrio, M.2    Cascante, A.3    Sangro, B.4
  • 3
    • 0037192631 scopus 로고    scopus 로고
    • Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation
    • Tomicic M.T., Thust R., Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002, 21:2141-2153.
    • (2002) Oncogene , vol.21 , pp. 2141-2153
    • Tomicic, M.T.1    Thust, R.2    Kaina, B.3
  • 4
    • 0033587708 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
    • Beltinger C., Fulda S., Kammertoens T., Meyer E., Uckert W., Debatin K.M. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. Proc. Natl. Acad. Sci. USA 1999, 96:8699-8704.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8699-8704
    • Beltinger, C.1    Fulda, S.2    Kammertoens, T.3    Meyer, E.4    Uckert, W.5    Debatin, K.M.6
  • 5
    • 14644411022 scopus 로고    scopus 로고
    • Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells
    • Fischer U., Steffens S., Frank S., Rainov N.G., Schulze-Osthoff K., Kramm C.M. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene 2005, 24:1231-1243.
    • (2005) Oncogene , vol.24 , pp. 1231-1243
    • Fischer, U.1    Steffens, S.2    Frank, S.3    Rainov, N.G.4    Schulze-Osthoff, K.5    Kramm, C.M.6
  • 6
    • 0035073139 scopus 로고    scopus 로고
    • Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells
    • Glaser T., Castro M.G., Lowenstein P.R., Weller M. Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells. Gene Ther. 2001, 8:469-476.
    • (2001) Gene Ther. , vol.8 , pp. 469-476
    • Glaser, T.1    Castro, M.G.2    Lowenstein, P.R.3    Weller, M.4
  • 7
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • Hamel W., Magnelli L., Chiarugi V.P., Israel M.A. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. 1996, 56:2697-2702.
    • (1996) Cancer Res. , vol.56 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Israel, M.A.4
  • 8
    • 0029774144 scopus 로고    scopus 로고
    • Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice
    • Reyes G., Villanueva A., Garcia C., Sancho F.J., Piulats J., Lluis F., Capella G. Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res. 1996, 56:5713-5719.
    • (1996) Cancer Res. , vol.56 , pp. 5713-5719
    • Reyes, G.1    Villanueva, A.2    Garcia, C.3    Sancho, F.J.4    Piulats, J.5    Lluis, F.6    Capella, G.7
  • 9
    • 33845733149 scopus 로고    scopus 로고
    • Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models
    • Huch M., Abate-Daga D., Roig J.M., Gonzalez J.R., Fabregat J., Sosnowski B., Mazo A., Fillat C. Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models. Hum. Gene Ther. 2006, 17:1187-1200.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 1187-1200
    • Huch, M.1    Abate-Daga, D.2    Roig, J.M.3    Gonzalez, J.R.4    Fabregat, J.5    Sosnowski, B.6    Mazo, A.7    Fillat, C.8
  • 10
    • 34848865695 scopus 로고    scopus 로고
    • GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model
    • Cascante A., Abate-Daga D., Garcia-Rodriguez L., Gonzalez J.R., Alemany R., Fillat C. GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model. Gene Ther. 2007, 14:1471-1480.
    • (2007) Gene Ther. , vol.14 , pp. 1471-1480
    • Cascante, A.1    Abate-Daga, D.2    Garcia-Rodriguez, L.3    Gonzalez, J.R.4    Alemany, R.5    Fillat, C.6
  • 11
    • 0032959726 scopus 로고    scopus 로고
    • Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene
    • Carrio M., Romagosa A., Mercade E., Mazo A., Nadal M., Gomez-Foix A.M., Fillat C. Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene. Gene Ther. 1999, 6:547-553.
    • (1999) Gene Ther. , vol.6 , pp. 547-553
    • Carrio, M.1    Romagosa, A.2    Mercade, E.3    Mazo, A.4    Nadal, M.5    Gomez-Foix, A.M.6    Fillat, C.7
  • 12
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002, 30:e36.
    • (2002) Nucleic Acids Res. , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 13
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 15
    • 12344330424 scopus 로고    scopus 로고
    • LimmaGUI: a graphical user interface for linear modeling of microarray data
    • Wettenhall J.M., Smyth G.K. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 2004, 20:3705-3706.
    • (2004) Bioinformatics , vol.20 , pp. 3705-3706
    • Wettenhall, J.M.1    Smyth, G.K.2
  • 18
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou T.C., Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 1984, 22:27-55.
    • (1984) Adv. Enzyme Regul. , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 20
    • 0028928572 scopus 로고
    • Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action
    • Ilsley D.D., Lee S.H., Miller W.H., Kuchta R.D. Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action. Biochemistry 1995, 34:2504-2510.
    • (1995) Biochemistry , vol.34 , pp. 2504-2510
    • Ilsley, D.D.1    Lee, S.H.2    Miller, W.H.3    Kuchta, R.D.4
  • 22
    • 0035174929 scopus 로고    scopus 로고
    • Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene
    • Garin M.I., Garrett E., Tiberghien P., Apperley J.F., Chalmers D., Melo J.V., Ferrand C. Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene. Blood 2001, 97:122-129.
    • (2001) Blood , vol.97 , pp. 122-129
    • Garin, M.I.1    Garrett, E.2    Tiberghien, P.3    Apperley, J.F.4    Chalmers, D.5    Melo, J.V.6    Ferrand, C.7
  • 23
    • 0031949646 scopus 로고    scopus 로고
    • Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene
    • Yang L., Hwang R., Chiang Y., Gordon E.M., Anderson W.F., Parekh D. Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene. Clin. Cancer Res. 1998, 4:731-741.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 731-741
    • Yang, L.1    Hwang, R.2    Chiang, Y.3    Gordon, E.M.4    Anderson, W.F.5    Parekh, D.6
  • 25
    • 1542619328 scopus 로고    scopus 로고
    • A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy
    • Mazumder S., DuPree E.L., Almasan A. A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. Curr. Cancer Drug Targets 2004, 4:65-75.
    • (2004) Curr. Cancer Drug Targets , vol.4 , pp. 65-75
    • Mazumder, S.1    DuPree, E.L.2    Almasan, A.3
  • 26
    • 34247564493 scopus 로고    scopus 로고
    • Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis
    • Mazumder S., Plesca D., Kinter M., Almasan A. Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis. Mol. Cell. Biol. 2007, 27:3511-3520.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3511-3520
    • Mazumder, S.1    Plesca, D.2    Kinter, M.3    Almasan, A.4
  • 27
    • 0036023401 scopus 로고    scopus 로고
    • Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer
    • Hildesheim J., Fornace A.J. Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. Clin. Cancer Res. 2002, 8:2475-2479.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2475-2479
    • Hildesheim, J.1    Fornace, A.J.2
  • 28
    • 12444327285 scopus 로고    scopus 로고
    • Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway
    • Missiaglia E., Donadelli M., Palmieri M., Crnogorac-Jurcevic T., Scarpa A., Lemoine N.R. Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene 2005, 24:199-211.
    • (2005) Oncogene , vol.24 , pp. 199-211
    • Missiaglia, E.1    Donadelli, M.2    Palmieri, M.3    Crnogorac-Jurcevic, T.4    Scarpa, A.5    Lemoine, N.R.6
  • 29
    • 59449098863 scopus 로고    scopus 로고
    • Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell
    • Li Y., Qian H., Li X., Wang H., Yu J., Liu Y., Zhang X., Liang X., Fu M., Zhan Q., Lin C. Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J. Gene Med. 2009, 11:3-13.
    • (2009) J. Gene Med. , vol.11 , pp. 3-13
    • Li, Y.1    Qian, H.2    Li, X.3    Wang, H.4    Yu, J.5    Liu, Y.6    Zhang, X.7    Liang, X.8    Fu, M.9    Zhan, Q.10    Lin, C.11
  • 30
    • 0032169967 scopus 로고    scopus 로고
    • Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing
    • Rubsam L.Z., Davidson B.L., Shewach D.S. Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing. Cancer Res. 1998, 58:3873-3882.
    • (1998) Cancer Res. , vol.58 , pp. 3873-3882
    • Rubsam, L.Z.1    Davidson, B.L.2    Shewach, D.S.3
  • 31
    • 34247481285 scopus 로고    scopus 로고
    • Targeting checkpoint kinase 1 in cancer therapeutics
    • Tse A.N., Carvajal R., Schwartz G.K. Targeting checkpoint kinase 1 in cancer therapeutics. Clin. Cancer Res. 2007, 13:1955-1960.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1955-1960
    • Tse, A.N.1    Carvajal, R.2    Schwartz, G.K.3
  • 32
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: chemosensitization versus chemoprotection
    • Zhou B.B., Bartek J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat. Rev. Cancer 2004, 4:216-225.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 33
    • 33745856631 scopus 로고    scopus 로고
    • Chk1 inhibitors for novel cancer treatment
    • Tao Z.F., Lin N.H. Chk1 inhibitors for novel cancer treatment. Anticancer Agents Med. Chem. 2006, 6:377-388.
    • (2006) Anticancer Agents Med. Chem. , vol.6 , pp. 377-388
    • Tao, Z.F.1    Lin, N.H.2
  • 34
    • 0034085228 scopus 로고    scopus 로고
    • Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase
    • McMasters R.A., Wilbert T.N., Jones K.E., Pitlyk K., Saylors R.L., Moyer M.P., Chambers T.C., Drake R.R. Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Ther. 2000, 7:563-573.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 563-573
    • McMasters, R.A.1    Wilbert, T.N.2    Jones, K.E.3    Pitlyk, K.4    Saylors, R.L.5    Moyer, M.P.6    Chambers, T.C.7    Drake, R.R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.