Metabolism of the major echinacea alkylamide N-isobutyldodeca-2E,4E,8Z,10Z- tetraenamide by human recombinant cytochrome P450 enzymes and human liver microsomes

Phytotherapy Research

Volumn 24, Issue 8, 2010, Pages 1195-1201

  Toselli, F ^a   Matthias, A ^b   Bone, K M ^b,c   Gillam, E M J ^a   Lehmann, R P ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MediHerb Research Laboratories   (Australia)

^c UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Alkylamide; Cytochrome P450; Echinacea; Herbal medicines

Indexed keywords

AMIDE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A13; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; ECHINACEA EXTRACT; N ISOBUTYLDODECATETRAENAMIDE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; EPOXIDE; N-ISOBUTYLDODECA-2E,4E,8Z,10Z-TETRAENAMIDE; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ECHINACEA; EPOXIDATION; HUMAN; HYDROXYLATION; LIVER MICROSOME; REACTION ANALYSIS; CHEMISTRY; METABOLISM;

CYTOCHROME P-450 ENZYME SYSTEM; ECHINACEA; EPOXY COMPOUNDS; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; POLYUNSATURATED ALKAMIDES; RECOMBINANT PROTEINS;

EID: 77955597356     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3111     Document Type: Article

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