Mechanism for recognition of polyubiquitin chains: Balancing affinity through interplay between multivalent binding and dynamics

Journal of the American Chemical Society

Volumn 132, Issue 32, 2010, Pages 11247-11258

  Markin, Craig J ^a   Xiao, Wei ^b   Spyracopoulos, Leo ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BOUND STATE; DNA DAMAGE RESPONSE; DNA DAMAGES; ENTROPIC EFFECTS; FAST KINETICS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MECHANISM; MULTIVALENT BINDING; MULTIVALENT INTERACTIONS; POLYUBIQUITIN; PROTEIN-PROTEIN INTERACTIONS; SIGNAL AMPLIFICATIONS; UBIQUITIN; UBIQUITIN-INTERACTING MOTIFS; WEAK BINDING; WEAK INTERACTIONS;

AMPLIFICATION; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; COMPLEXATION; DNA; DYNAMICS; GENES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNAL PROCESSING; SIGNAL TRANSDUCTION;

PROTEINS;

POLYUBIQUITIN; PROTEIN RAP80; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; BINDING AFFINITY; DNA DAMAGE; GENE AMPLIFICATION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOLID STATE; THERMODYNAMICS;

KINETICS; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY; UBIQUITIN; ZINC FINGERS;

EID: 77955562403     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103869x     Document Type: Article

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